公开(公告)号：US07674900B2

公开(公告)日：2010-03-09

申请号：US11578708

申请日：2005-05-11

Applicant: Albert Sun-Chi Chan ,  Gang Chen ,  Rongwei Guo ,  Jing Wu

Inventor： Albert Sun-Chi Chan ,  Gang Chen ,  Rongwei Guo ,  Jing Wu

IPC: C07F9/6544

CPC classification number: B01J31/2409 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07F9/6512 ,  C07F15/0066

Abstract: The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.

Abstract translation: 本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。 式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。 根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

公开(公告)号：US07660805B2

公开(公告)日：2010-02-09

申请号：US11010303

申请日：2004-12-14

Applicant: Sammy Chan ,  Nicole Ai Ling Lam ,  Alison Joan Lennon ,  Jing Wu

Inventor： Sammy Chan ,  Nicole Ai Ling Lam ,  Alison Joan Lennon ,  Jing Wu

IPC: G06F7/00 ,  G06F17/00

CPC classification number: G06F17/30292 ,  Y10S707/99942

Abstract: A query system (1600) is formed by a wizard (1605) operating to form a data server (1610) arranged to serve data from a data source (1615) to a client application (1630), each of the wizard, the client application, the data server and the data source being linked by a communications network (1650). The data source has native data types and data arranged in a data structure. The wizard operates to firstly identify the data source over the network. The wizard further provides an application program for traversing and examining at least one of the data structure and data of the identified data source. The application program is operable to generate a representative schema (1614) comprising mapping data for converting the native data types to predetermined data types of a common data model. The wizard further operates to create a server application (1612) adapted to use the representative schema to convert the data from the native data types to the predetermined data types and to serve the data to the client application according to the common data model over the network. The representative schema and the server application thereby form the data server generated by the wizard. Once formed, the data server may receive and respond to queries from the client application, which may have no knowledge of the native data types, but which are directed to the data source.

Abstract translation: 由向导（1605）形成查询系统（1605），该向导（1605）操作以形成数据服务器（1610），该数据服务器被布置为从数据源（1615）向客户端应用（1630）提供数据，每个向导，客户端应用 ，数据服务器和数据源由通信网络（1650）链接。 数据源具有以数据结构排列的原生数据类型和数据。 该向导将首先通过网络识别数据源。 向导还提供了用于遍历和检查所识别的数据源的数据结构和数据中的至少一个的应用程序。 应用程序可操作以产生代表性模式（1614），其包括用于将本地数据类型转换为公共数据模型的预定数据类型的映射数据。 向导进一步操作以创建适于使用代表性模式将数据从本机数据类型转换为预定数据类型的服务器应用程序（1612），并根据网络上的公共数据模型将数据提供给客户端应用程序 。 因此，代表性模式和服务器应用程序形成了向导生成的数据服务器。 一旦形成，数据服务器可以接收并响应来自客户端应用程序的查询，客户端应用程序可能不知道本机数据类型，但是哪些是针对数据源的。

公开(公告)号：US07584219B2

公开(公告)日：2009-09-01

申请号：US10669866

申请日：2003-09-24

Applicant: John H. Zybura ,  Max L. Benson ,  Herman Man ,  Edward H. Wayt ,  Felix W. Wong ,  Jing Wu

Inventor： John H. Zybura ,  Max L. Benson ,  Herman Man ,  Edward H. Wayt ,  Felix W. Wong ,  Jing Wu

IPC: G06F17/30 ,  G06F17/00 ,  G06F15/16

CPC classification number: G06F17/30575 ,  Y10S707/99931 ,  Y10S707/99945 ,  Y10S707/99953

Abstract: Described are mechanisms and techniques for enabling incremental non-chronological synchronization of namespaces. In an environment, entities must have unique names within a namespace and entities may only refer to entities that actually exist within the namespace. Synchronizing two such namespaces involves providing a mechanism for indicating that an entity has been created because a reference to that entity has been made even though that entity does not yet exist. At such time as the entity is formally created, the indication is removed. Synchronizing two such namespaces also involves providing a mechanism for indicating that an entity's unique name in the namespace has been compromised through the synchronization process.

Abstract translation: 描述了用于实现命名空间的增量非时间同步的机制和技术。 在一个环境中，实体必须在命名空间中具有唯一的名称，实体只能引用在命名空间中实际存在的实体。 同步两个这样的命名空间涉及提供用于指示实体已经被创建的机制，因为即使该实体不存在也已经创建了对该实体的引用。 在实体正式创建的时候，指示被移除。 同步两个这样的命名空间还涉及提供一种机制，用于指示实体在命名空间中的唯一名称已经通过同步过程进行了泄露。

公开(公告)号：US20080269490A1

公开(公告)日：2008-10-30

申请号：US11816139

申请日：2006-02-16

Applicant: Albert Sun-Chi Chan ,  Jianxin Ji ,  Jing Wu

Inventor： Albert Sun-Chi Chan ,  Jianxin Ji ,  Jing Wu

IPC: C07F1/08 ,  C07F7/12 ,  C07F15/00

CPC classification number: C07C29/143 ,  B01J31/1815 ,  B01J31/2409 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/16 ,  C07B2200/07 ,  C07C33/18 ,  C07C33/22 ,  C07C33/24 ,  C07C33/46

Abstract: Method of asymmetrically hydrosilylating substrates using catalysts having a ligand of the compound of the formula (I) wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ is hydrogen, optionally substituted lower alkyl; and R″ is hydrogen, halogen, optionally substituted alkyl, hydroxy, amino (e.g., primary, secondary or tertiary), alkenyl; or an enantiomer thereof; or an enantiomeric mixture thereof with a transition metal. Particularly suitable reactions include the asymmetric hydrosilylation of ketones.

Abstract translation: 使用具有式（I）化合物的配体的催化剂的不对称氢化硅烷化方法，其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'是氢，任选取代的低级烷基; 和R“是氢，卤素，任选取代的烷基，羟基，氨基（例如伯，仲或叔），烯基; 或其对映体; 或其与过渡金属的对映体混合物。 特别合适的反应包括酮的不对称氢化硅烷化。

公开(公告)号：US20080255356A1

公开(公告)日：2008-10-16

申请号：US12133551

申请日：2008-06-05

Applicant: Albert Sun-Chi Chan ,  Gang Chen ,  Rongwei Guo ,  Jing Wu

Inventor： Albert Sun-Chi Chan ,  Gang Chen ,  Rongwei Guo ,  Jing Wu

IPC: C07F15/00 ,  C07F9/6512

CPC classification number: B01J31/2409 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07F9/6512 ,  C07F15/0066

Abstract: The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.

Abstract translation: 本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。 式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。 根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

公开(公告)号：US07417152B2

公开(公告)日：2008-08-26

申请号：US10555519

申请日：2004-04-30

Applicant: Jay S. Tung ,  Albert W. Garofalo ,  Michael A. Pleiss ,  Jing Wu ,  David W. G. Wone ,  Ashley C. Guinn ,  Darren B. Dressen ,  R. Jeffrey Neitz ,  Jennifer Marugg ,  Martin Neitzel

Inventor： Jay S. Tung ,  Albert W. Garofalo ,  Michael A. Pleiss ,  Jing Wu ,  David W. G. Wone ,  Ashley C. Guinn ,  Darren B. Dressen ,  R. Jeffrey Neitz ,  Jennifer Marugg ,  Martin Neitzel

IPC: C07D231/12 ,  C07D233/04

CPC classification number: C07D401/14 ,  C07D231/16 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D487/08

Abstract: Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

Abstract translation: 公开了作为缓激肽B 1受体拮抗剂的式I和II化合物，并且可用于治疗由缓激肽B 1介导的哺乳动物中疾病或与疾病相关的不良症状， SUB>受体。 某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

公开(公告)号：US20070049612A1

公开(公告)日：2007-03-01

申请号：US11465726

申请日：2006-08-18

Applicant: Simeon Bowers ,  Albert Garofalo ,  Roy Hom ,  Andrei Konradi ,  Matthew Mattson ,  Martin Neitzel ,  Christopher Semko ,  Anh Truong ,  Jing Wu ,  Ying-zi Xu

Inventor： Simeon Bowers ,  Albert Garofalo ,  Roy Hom ,  Andrei Konradi ,  Matthew Mattson ,  Martin Neitzel ,  Christopher Semko ,  Anh Truong ,  Jing Wu ,  Ying-zi Xu

IPC: A61K31/4745 ,  A61K31/46 ,  C07D451/02

CPC classification number: C07D451/14 ,  C07D471/08 ,  C07D471/18 ,  C07D471/22 ,  C07D498/08

Abstract: The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.

Abstract translation: 本发明提供N-环磺酰氨基化合物和式I的盐：其中A如说明书中所述，R 1和R 2 2结合形成[3.3.1 ]或[3.2.1]环体系，其中氮连接到两个桥头堡碳上，并且[3.3.1]或[3.2.1]环体系任选地与杂芳基或杂环烷基环稠合。 式I的化合物可用于治疗或预防认知障碍，例如阿尔茨海默病。 本发明还包括含有式I化合物的药物组合物，治疗认知障碍的方法，例如阿尔茨海默氏病，以及可用于制备式I化合物的中间体。

公开(公告)号：US06861558B2

公开(公告)日：2005-03-01

申请号：US10309569

申请日：2002-12-03

Applicant: James E. Audia ,  Thomas C. Britton ,  James J. Droste ,  Beverly K. Folmer ,  George W. Huffman ,  Varghese John ,  Lee H. Latimer ,  Thomas E. Mabry ,  Jeffrey S. Nissen ,  Warren J. Porter ,  Jon K. Reel ,  Eugene D. Thorsett ,  Jay S. Tung ,  Jing Wu ,  Clark Norman Eid ,  William Leonard Scott

Inventor： James E. Audia ,  Thomas C. Britton ,  James J. Droste ,  Beverly K. Folmer ,  George W. Huffman ,  Varghese John ,  Lee H. Latimer ,  Thomas E. Mabry ,  Jeffrey S. Nissen ,  Warren J. Porter ,  Jon K. Reel ,  Eugene D. Thorsett ,  Jay S. Tung ,  Jing Wu ,  Clark Norman Eid ,  William Leonard Scott

IPC: A61K31/00 ,  A61K38/05 ,  A61K38/06 ,  C07K5/06 ,  C07K5/065 ,  C02C233/00

CPC classification number: C07K5/06191 ,  A61K31/00 ,  A61K31/4015 ,  A61K31/405 ,  A61K31/445 ,  A61K31/47 ,  A61K38/05 ,  A61K38/06 ,  C07K5/06078

Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06724937B1

公开(公告)日：2004-04-20

申请号：US09334177

申请日：1999-06-16

Applicant: Jing Wu ,  John Richard Windle

Inventor： Jing Wu ,  John Richard Windle

IPC: G06K920

CPC classification number: G06T7/41

Abstract: A method for identifying one or more image frames (100) from a series (104) of video image frames, in order to print, store or flag the selected frames. The method calculates a gradient value for each image frame in a video shot (102) series, identifies one or more gradient value peaks (324) in a corresponding range of a raw data series (302), and selects the image frames (110) corresponding to the identified gradient value peaks. Two types of frames (202, 206) are identified as being suitable for printing. A first type (202) comprises frames with a high gradient content, where the image is sharply defined. A second type of frame (206) also has good focus, but is representative of periods of relative stillness, or lack of motion between consecutive image frames (100) during the video shot series (104).

Abstract translation: 一种用于从视频图像帧的系列（104）中识别一个或多个图像帧（100）的方法，以便打印，存储或标记所选择的帧。 该方法为视频拍摄（102）系列中的每个图像帧计算梯度值，识别原始数据序列（302）的相应范围中的一个或多个梯度值峰值（324），并选择图像帧（110） 对应于所识别的梯度值峰值。 两种类型的帧（202,206）被识别为适于打印。 第一类型（202）包括具有高梯度内容的帧，其中图像被清晰地定义。 第二类型的帧（206）也具有良好的焦点，但是代表在视频拍摄序列（104）期间连续的图像帧（100）之间的相对静止的周期或缺乏运动。

公开(公告)号：US06718063B1

公开(公告)日：2004-04-06

申请号：US09458063

申请日：1999-12-10

Applicant: Alison Joan Lennon ,  Jing Wu

Inventor： Alison Joan Lennon ,  Jing Wu

IPC: G06K962

CPC classification number: G06K9/00697 ,  G06K9/469 ,  Y10S707/99936

Abstract: The method first segments both images into homogeneous regions (205A) and assigns (207A) semantic labels (such as “sky”, “cloud”, “water”, “foliage” etc) to the homogeneous regions to describe the content of the regions using a probabilistic method. This process also results in each assigned label for a region having an associated probability value expressing the confidence level of the label being correctly assigned The method then computes (108) a distance metric which averages over all corresponding pixels in the two images a value which is the product of a predetermined semantic difference between the assigned labels at the corresponding pixels and a weighting function which is derived from the associated probability values of the labels for each of the corresponding pixels. The semantic difference reflects similarities between the labels. For example, the semantic difference of the label pair “sky” and “foliage” is higher than the semantic difference between the more similar “sky” and “cloud” label pair. The method then compares (110) the distance metric value with a predetermined threshold value in order to determine the similarity of the images.

Abstract translation: 该方法首先将两个图像分割成均匀区域（205A），并将（207A）语义标签（例如“天空”，“云”，“水”，“叶子等”）分配给均匀区域以描述区域的内容 使用概率方法，该过程还导致具有表示标签的置信水平正确分配的相关联概率值的区域的每个分配的标签。然后，该方法计算（108）在两者中的所有相应像素上平均的距离度量 将相应像素上分配的标签之间的预定语义差异的乘积和从每个相应像素的标签的相关概率值导出的加权函数的乘积映射成一个值，语义差异反映了标签之间的相似性 例如，标签对“天空”和“叶子”的语义差异高于更相似的“天空”之间的语义差异， 和“云”标签对。 然后，该方法将距离度量值与预定阈值进行比较（110），以便确定图像的相似性。