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公开(公告)号：US09034356B2
公开(公告)日：2015-05-19
申请号：US11625086
申请日：2007-01-19
申请人： Lawrence A. Shimp , John Winterbottom , David R. Kaes , Ryan M. Belaney , Subhabrata Bhattacharyya
发明人： Lawrence A. Shimp , John Winterbottom , David R. Kaes , Ryan M. Belaney , Subhabrata Bhattacharyya
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
摘要： The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
摘要翻译： 本发明涉及用于骨缺损部位以促进新骨生长的多孔复合材料。 本发明的多孔复合材料包括生物相容性聚合物和多种骨源材料，无机材料，骨替代材料或复合材料的颗粒。 在某些实施方案中，使用包括超临界流体（例如超临界二氧化碳）处理的方法制备多孔复合材料。 本发明还公开了使用这些复合材料作为骨空隙填料的方法。
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公开(公告)号：US09492278B2
公开(公告)日：2016-11-15
申请号：US12171168
申请日：2008-07-10
申请人： Guobao Wei , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US09265830B2
公开(公告)日：2016-02-23
申请号：US13090745
申请日：2011-04-20
CPC分类号： A61L27/3608 , A61K9/0024 , A61K9/06 , A61K35/32 , A61K38/1875 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2430/02
摘要： Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture; and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.
摘要翻译： 提供了可植入组合物的形成方法。 在一些实施方案中，所述方法包括（i）提供凝胶基质，（ii）向凝胶基质中加入水和水合剂以形成混合物，（iii）降低混合物的水含量; 和（iv）在步骤（ii）或（iii）之前，期间和/或之后加入递送的材料。 含水量降低至可植入组合物重量的约5％或更少。
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公开(公告)号：US08562648B2
公开(公告)日：2013-10-22
申请号：US12914051
申请日：2010-10-28
IPC分类号： A61B17/70
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
摘要翻译： 在手术中使用的植入单元具有由成骨可植入材料制成的主体，并且包括植入部分和保持部分，该部分与植入部分相连并横向延伸。 保持部分附接到邻接的椎体或哺乳动物骨的侧壁，以防止植入部分相对于椎体或哺乳动物骨骼移位，并加速其间的融合。
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公开(公告)号：US08425893B2
公开(公告)日：2013-04-23
申请号：US13181715
申请日：2011-07-13
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译： 生物基聚氨酯及其制备方法。 聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。 形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。
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36.发明授权Bioimplant with nonuniformly configured protrusions on the load bearing surfaces thereof 有权在其承载表面上具有不均匀构造的突起的生物植入物公开(公告)号：US07988733B2
公开(公告)日：2011-08-02
申请号：US11292809
申请日：2005-12-02
IPC分类号： A61F2/44
CPC分类号： A61F2/30771 , A61F2/4455 , A61F2002/2835 , A61F2002/30059 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30136 , A61F2002/30151 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30159 , A61F2002/30205 , A61F2002/30224 , A61F2002/30263 , A61F2002/30273 , A61F2002/30828 , A61F2002/30879 , A61F2002/30892 , A61F2002/4649 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0028 , A61F2230/0067 , A61F2230/0069 , A61F2230/0084 , A61F2230/0086 , A61F2310/00293
摘要： A bioimplant is configured with at least two load-bearing surfaces each having a plurality of protrusions oriented at an angle with respect to one another to resist translation in all directions when opposing load bearing surfaces are under normally applied compressive loads.
摘要翻译： 生物植入物被构造成具有至少两个承载表面，每个承载表面各自具有相对于彼此成一定角度取向的多个突起，以在相反的承载表面处于正常施加的压缩载荷下时在所有方向上抵抗平移。
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37.发明申请Transforaminal Lumbar Interbody Fusion (TLIF) Implant, Surgical Procedure and Instruments for Insertion of Spinal Implant in a Spinal Disc Space 审中-公开经椎间孔腰椎间融合术（TLIF）植入物，脊柱植入物插入椎间盘空间的外科手术和手术公开(公告)号：US20110082555A1
公开(公告)日：2011-04-07
申请号：US12942299
申请日：2010-11-09
申请人： Erik O. Martz , John Kuras , John Winterbottom , Craig J. Stratton , David S. Marques , Lawrene A. Shimp
发明人： Erik O. Martz , John Kuras , John Winterbottom , Craig J. Stratton , David S. Marques , Lawrene A. Shimp
IPC分类号： A61F2/44
CPC分类号： A61F2/30771 , A61B17/1606 , A61B17/1659 , A61B17/1671 , A61B17/1684 , A61B17/7001 , A61B2017/0046 , A61B2017/0256 , A61B2090/062 , A61F2/28 , A61F2/4455 , A61F2/4611 , A61F2/4684 , A61F2002/30131 , A61F2002/30774 , A61F2002/30892 , A61F2002/30904 , A61F2002/4475 , A61F2002/448 , A61F2002/4622 , A61F2002/4628 , A61F2230/0013 , A61F2310/00359
摘要： Various instrumentation, implants and methodology are disclosed for implanting bone implants in the TLIF approach. The implants are preferably cortical bone of various shapes. The instruments include chisels, rasps, trials, inserters, spreaders, adjustors, curettes, rongeurs, and impactors. The instruments have straight and bent shafts. The implants may have recesses or notches in their sides for receipt of a mating insertion instrument. Some of the implants have a threaded hole for receiving a mating threaded stud of an implant insertion instrument. The implants may have saw tooth vertebral gripping surfaces which are lordotic or parallel, may be C-shaped, multi-faceted or annular.
摘要翻译： 公开了在TLIF方法中植入骨植入物的各种仪器，植入物和方法。 植入物优选为各种形状的皮质骨。 仪器包括凿子，锉刀，试验，插入器，吊具，调节器，刮刀，护腿和冲击器。 仪器具有直的和弯曲的轴。 植入物在其侧面可以具有凹口或凹口以接收配合的插入器械。 一些植入物具有用于接收植入物插入器械的配合螺柱的螺纹孔。 植入物可具有锯齿状的脊椎牵引表面，其为脊柱状或平行的，可为C形，多面或环形。
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公开(公告)号：US20090192474A1
公开(公告)日：2009-07-30
申请号：US12171125
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US20110040334A1
公开(公告)日：2011-02-17
申请号：US12914051
申请日：2010-10-28
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
摘要翻译： 在手术中使用的植入单元具有由成骨可植入材料制成的主体，并且包括植入部分和保持部分，该部分与植入部分相连并横向延伸。 保持部分附接到邻接的椎体或哺乳动物骨的侧壁，以防止植入部分相对于椎体或哺乳动物骨骼移位，并加速其间的融合。
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公开(公告)号：US07833245B2
公开(公告)日：2010-11-16
申请号：US10483804
申请日：2002-07-12
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
摘要翻译： 在手术中使用的植入单元具有由成骨可植入材料制成的主体，并且包括植入部分和保持部分，该部分与植入部分相连并横向延伸。 保持部分附接到邻接的椎体或哺乳动物骨的侧壁，以防止植入部分相对于椎体或哺乳动物骨骼移位，并加速其间的融合。
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