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    Breath-based sensors for non-invasive molecular detection
    31.
    发明授权
    Breath-based sensors for non-invasive molecular detection 有权
    基于呼吸的传感器用于非侵入性分子检测

    公开(公告)号：US07992422B2

    公开(公告)日：2011-08-09

    申请号：US12192038

    申请日：2008-08-14

    Applicant: Johna Leddy ,  Luke M. Haverhals

    Inventor： Johna Leddy ,  Luke M. Haverhals

    IPC: G01N1/22

    CPC classification number: G01N33/497 ,  G01N33/4972 ,  H01M8/04753 ,  H01M8/1023 ,  H01M8/1039 ,  H01M2250/00 ,  Y10S436/90

    Abstract: A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each analytes is measured by fitting a time response curve of a sample-evaluation fuel cell in which the fuel cell sample electrode is contacted with the sample with the analysis based on a function of standard time response curves for an equivalent fuel cell configuration obtained separately for each of the analytes on a fuel cell with equivalent construction as sample-evaluation fuel cell. Each of the plurality of analytes is generally indicative of an aspect of the individual's health. Suitable analytes include, for example, inorganic compounds as well as compositions that exhibit negative reduction reactions at least for a portion of the time response curve. In particular, acetone exhibits a negative potential/current peak when it is an analyte in a fuel cell in an sample electrode with a counter electrode exposed to oxygen, which may or may not be introduced in the form of air. Various forms of analysis to estimate acetone concentrations in the breath can be used.

    Abstract translation: 一种通过从个体收集呼吸样本并测量样品中多个分析物中的每一个的量来诊断个体健康的方法。 通过根据等效燃料电池配置的标准时间响应曲线的函数，通过拟合燃料电池样品电极与样品接触的样品评估燃料电池的时间响应曲线来测量每种分析物的量 在具有等效结构的燃料电池上的每个分析物分别获得作为样品评价燃料电池。 多个分析物中的每一个通常表示个体健康的一个方面。 合适的分析物包括例如无机化合物以及至少对于时间响应曲线的一部分呈现负还原反应的组合物。 特别是丙酮在样品电极中的分析物处于负电势/电流峰值时，其对置电极暴露于氧气，这可能是或可能不以空气的形式引入。 可以使用各种形式的分析来估计呼吸中的丙酮浓度。

    BREATH-BASED SENSORS FOR NON-INVASIVE MOLECULAR DETECTION
    34.
    发明申请
    BREATH-BASED SENSORS FOR NON-INVASIVE MOLECULAR DETECTION 审中-公开

    公开(公告)号：US20080302170A1

    公开(公告)日：2008-12-11

    申请号：US12192056

    申请日：2008-08-14

    Applicant: Johna Leddy ,  Luke M. Haverhals

    Inventor： Johna Leddy ,  Luke M. Haverhals

    IPC: G01N1/22

    CPC classification number: G01N33/497 ,  G01N33/4972 ,  H01M8/04753 ,  H01M8/1023 ,  H01M8/1039 ,  H01M2250/00 ,  Y10S436/90

    Abstract: A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each analytes is measured by fitting a time response curve of a sample-evaluation fuel cell in which the fuel cell sample electrode is contacted with the sample with the analysis based on a function of standard time response curves for an equivalent fuel cell configuration obtained separately for each of the analytes on a fuel cell with equivalent construction as sample-evaluation fuel cell. Each of the plurality of analytes is generally indicative of an aspect of the individual's health. Suitable analytes include, for example, inorganic compounds as well as compositions that exhibit negative reduction reactions at least for a portion of the time response curve. In particular, acetone exhibits a negative potential/current peak when it is an analyte in a fuel cell in an sample electrode with a counter electrode exposed to oxygen, which may or may not be introduced in the form of air. Various forms of analysis to estimate acetone concentrations in the breath can be used.

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