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公开(公告)号：US08309023B2
公开(公告)日：2012-11-13
申请号：US12649044
申请日：2009-12-29
CPC分类号： A61L2/20 , A61F2/958 , A61L2/08 , A61L2/087 , A61L2/206 , A61L2/208 , A61L2202/10 , A61L2202/24 , A61M25/0097 , A61M25/10 , A61M2025/0019
摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.
摘要翻译： 描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。 单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。 另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。
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32.发明授权Method of intravascularly delivering stimulation leads into direct contact with tissue 失效血管内传递刺激的方法导致与组织直接接触公开(公告)号：US08060207B2
公开(公告)日：2011-11-15
申请号：US10744853
申请日：2003-12-22
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译： 提供了一种治疗患者疾病的方法。 该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。 使用刺激铅，然后可以刺激组织以治疗该疾病。
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33.发明申请公开(公告)号：US20100249823A1
公开(公告)日：2010-09-30
申请号：US12814397
申请日：2010-06-11
IPC分类号： A61M29/00
CPC分类号： A61B17/221 , A61B17/12 , A61B17/12113 , A61B17/1214 , A61B2017/00411 , A61B2017/12068 , A61B2090/037
摘要： The apparatus for deployment of an intravascular therapeutic device, includes an elongated, flexible pusher member and a therapeutic device connected to a severable portion of a first connector member mounted to the flexible pusher member with an elongated second connector member connected to the therapeutic device. The first connector member or second connector member may be capable of being broken by heat, and a heat source is provided for heating and breaking the first connector member or the second connector member to release the therapeutic device.
摘要翻译： 用于部署血管内治疗装置的装置包括细长的，柔性的推动器构件和治疗装置，其连接到安装到柔性推动器构件的第一连接器构件的可分离部分，连接到治疗装置的细长的第二连接器构件。 第一连接器构件或第二连接器构件可以被热分解，并且提供热源用于加热和断开第一连接器构件或第二连接器构件以释放治疗装置。
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公开(公告)号：US20100185270A1
公开(公告)日：2010-07-22
申请号：US12649044
申请日：2009-12-29
CPC分类号： A61L2/20 , A61F2/958 , A61L2/08 , A61L2/087 , A61L2/206 , A61L2/208 , A61L2202/10 , A61L2202/24 , A61M25/0097 , A61M25/10 , A61M2025/0019
摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.
摘要翻译： 描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。 单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。 另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。
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公开(公告)号：US20090319028A1
公开(公告)日：2009-12-24
申请号：US12143659
申请日：2008-06-20
申请人： Kamal Ramzipoor , Alfred N.K. Chia , Liwei Wang
发明人： Kamal Ramzipoor , Alfred N.K. Chia , Liwei Wang
CPC分类号： B29C41/14 , A61F2/07 , A61F2/24 , A61F2/82 , A61F2002/30062 , A61F2002/30535 , A61F2210/0004 , A61F2210/0019 , A61F2240/004 , A61L31/04 , A61L31/06 , A61L31/14 , A61L31/148 , A61L31/16 , B29C41/003 , B29C49/00 , B29K2105/0035 , B29K2995/0056 , B29L2031/7532
摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.
摘要翻译： 可以使用诸如浸涂的管状浇铸工艺从聚合物溶液形成基底，其可用于制造可植入装置，例如支架。 聚合物基材可以具有多个层，其保持其起始材料的固有性质，并且其具有足够的延展性以防止脆性断裂。 浸入芯棒的次数，溶液中每次浸渍的持续时间以及每次浸渍之间的延迟时间，浸渍之间的干燥或固化时间以及心轴从溶液中提取速率之类的参数可以 每个都被控制以产生期望的机械特性。 还可以使用额外的后处理来进一步增加基底的强度或改变其形状。
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公开(公告)号：US07578826B2
公开(公告)日：2009-08-25
申请号：US11699308
申请日：2007-01-29
申请人： Deepak Gandhi , Kamal Ramzipoor
发明人： Deepak Gandhi , Kamal Ramzipoor
CPC分类号： A61B17/12113 , A61B17/12 , A61B17/12022 , A61B17/12136 , A61B17/1214 , A61B2017/00477 , A61B2017/00867 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209 , A61B2018/00005 , A61B2090/037 , A61F2002/9505 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a tubular collar that can be heated by a heater such as an electrical resistance coil to expand the collar and release and deploy the therapeutic device. The apparatus for deployment of a therapeutic device such as a micro-coil may also provide for a pusher member and a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a heater within the distal portion of the pusher member, for heating and breaking the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.
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公开(公告)号：US20080269798A1
公开(公告)日：2008-10-30
申请号：US12171033
申请日：2008-07-10
申请人： Kamal Ramzipoor , Ajitkumar B. Nair , Riten Parikh , Andrew Huffmaster , Mehran Bashiri , Pete Phong Pham
发明人： Kamal Ramzipoor , Ajitkumar B. Nair , Riten Parikh , Andrew Huffmaster , Mehran Bashiri , Pete Phong Pham
IPC分类号： A61M1/34
CPC分类号： A61B17/22012 , A61B17/221 , A61B2017/22034 , A61B2017/2215 , A61M25/0069 , A61M2025/0004
摘要： An embodiment is a catheter comprising a first elongate shaft having a proximal end, a distal end and a first lumen therethrough, a wire having a proximal end and a distal end at least partially disposed in the first elongate shaft, the distal end extending distally from the first elongate shaft, and a motion control apparatus connected to the proximal end of the wire, further comprising a device attached to the distal end of the wire for changing the shape of an embolus, wherein the device is configured to change the shape of the embolus to unclog a distal catheter lumen.
摘要翻译： 一个实施例是一种导管，其包括具有近端，远端和穿过其中的第一腔的第一细长轴，具有至少部分地设置在第一细长轴中的近端和远端的线，远端从 所述第一细长轴和连接到所述线的近端的运动控制装置还包括附接到所述线的远端以用于改变栓子的形状的装置，其中所述装置被配置为改变所述线的形状 栓塞阻塞远端导管管腔。
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38.发明申请公开(公告)号：US20070239191A1
公开(公告)日：2007-10-11
申请号：US11278768
申请日：2006-04-05
申请人： Kamal Ramzipoor
发明人： Kamal Ramzipoor
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00398 , A61B2017/1209
摘要： A vaso-occlusive delivery device includes an elongate delivery member which may take the form of a core wire. An actuating member is disposed at or adjacent to the distal end of the delivery member. The actuating member includes an electroactive polymer that can be selectively biased to an expanded or non-expanded state by application of direct current of different polarities. A vaso-occlusive device such as a coil may be detachably secured to the delivery device by expanding the actuating member within a proximal end of the coil to form an interference or friction fit using a first direct current polarity. The coil may be disengaged from the delivery member by application of direct current of a second, opposite polarity.
摘要翻译： 血管闭塞递送装置包括可以采取芯线形式的细长递送构件。 致动构件设置在输送构件的远端处或邻近输送构件的远端。 致动构件包括电活性聚合物，其可以通过施加不同极性的直流电而选择性地偏置到扩展或非膨胀状态。 诸如线圈的血管闭塞装置可以通过在线圈的近端内扩大致动构件而使用第一直流极性形成干涉或摩擦配合来可拆卸地固定到输送装置。 线圈可以通过施加第二相反极性的直流而与输送构件分离。
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公开(公告)号：US20060135986A1
公开(公告)日：2006-06-22
申请号：US11022189
申请日：2004-12-22
申请人： Michael Wallace , Kamal Ramzipoor
发明人： Michael Wallace , Kamal Ramzipoor
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. A delivery catheter can be used to deliver the vaso-occlusive member to the vascular site. A method of using the assembly to occlude an aneurysm having an aneurysmal sac and an aneurysmal neck, comprises locating the catheter within the aneurysmal neck, and manipulating the pusher member to place the vaso-occlusive member within the aneurysmal sac. The method further comprises severing the severable junction to detach the vaso-occlusive member from the pusher member. As a result, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译： 用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件 推动器构件到闭塞构件。 输送导管可用于将血管闭塞成员递送至血管部位。 一种使用所述组件闭塞具有动脉瘤囊和动脉瘤颈部的动脉瘤的方法，包括将所述导管定位在所述动脉瘤颈内，以及操纵所述推动器构件以将所述血管闭塞构件置于所述动脉瘤囊内。 该方法还包括切断可分开的连接点以将血管闭塞构件与推动器构件分离。 结果，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。 由可枢转联轴器的弯曲引起的轴向力的横向偏转防止导管通过轴向力从动脉瘤颈部移位。
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公开(公告)号：US06966892B2
公开(公告)日：2005-11-22
申请号：US10290777
申请日：2002-11-07
申请人： Deepak Gandhi , Kamal Ramzipoor
发明人： Deepak Gandhi , Kamal Ramzipoor
CPC分类号： A61B17/12113 , A61B17/12 , A61B17/12022 , A61B17/12136 , A61B17/1214 , A61B2017/00477 , A61B2017/00867 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209 , A61B2018/00005 , A61B2090/037 , A61F2002/9505 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a tubular collar that can be heated by a heater such as an electrical resistance coil to expand the collar and release and deploy the therapeutic device. The apparatus for deployment of a therapeutic device such as a micro-coil may also provide for a pusher member and a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a heater within the distal portion of the pusher member, for heating and breaking the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.
摘要翻译： 用于展开诸如微型线圈的治疗装置的装置将治疗装置可拆卸地安装到推动器构件的远侧部分。 在一个实施例中，治疗装置通过可被诸如电阻线圈的加热器加热的管状套环可拆卸地安装到推动器构件的远端部分，以扩大套环并释放和展开治疗装置。 用于展开诸如微型线圈的治疗装置的装置还可以提供用于将治疗装置固定到推动器构件的推动器构件和连接器纤维。 连接器纤维通过在推动器构件的远端部分内的加热器，用于加热和断开连接器纤维以在实现治疗装置在脉管系统期望的放置期间释放治疗装置。
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