公开(公告)号：US20120172972A1

公开(公告)日：2012-07-05

申请号：US13239098

申请日：2011-09-21

申请人： Michael P. Meyer ,  Timothy J. Mickley

发明人： Michael P. Meyer ,  Timothy J. Mickley

IPC分类号： A61F2/82

CPC分类号： A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2230/0054 ,  A61F2250/0036

摘要： In at least one embodiment, a stent comprises an unexpanded configuration, a nominally expanded configuration, and a fully expanded configuration. The stent further comprises a plurality of circumferential bands and a plurality of connectors connecting adjacent circumferential bands to one another. Each circumferential band has a plurality of struts interconnected by bridges. Adjacent struts form strut pairs and are connected to one another at a first end or a second end but not both. Each strut pair defines an opening between the struts of the strut pair; the bridges extend into the openings. In the unexpanded configuration, the struts are straight along their length. Also in the unexpanded configuration, the bridges comprise two adjacent straight segments that are connected by a u-shaped segment, and the straight segments are parallel to one another and to the longitudinal axis of the stent.

摘要翻译： 在至少一个实施例中，支架包括未膨胀构型，标称扩张构型和完全扩张构型。 支架还包括多个周向带和将相邻周向带彼此连接的多个连接器。 每个周向带具有通过桥互连的多个支柱。 相邻的支柱形成支柱对，并且在第一端或第二端彼此连接，但不是两者连接。 每个支柱对限定支柱对的支柱之间的开口; 桥梁延伸到开口中。 在未膨胀的配置中，支柱沿其长度是直的。 同样在未膨胀的构造中，桥包括两个相邻的直段，其通过U形段连接，并且直段彼此平行并且与支架的纵向轴线平行。

公开(公告)号：US07695455B2

公开(公告)日：2010-04-13

申请号：US10882397

申请日：2004-07-02

申请人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

发明人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

IPC分类号： A61M5/178 ,  A61M5/24 ,  A61M5/00

CPC分类号： A61M25/104 ,  A61M5/00 ,  A61M29/02 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1093

摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen. A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.

摘要翻译： 导管系统包括具有近端，远端和在其中延伸的内腔的导管。 给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。 本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。 本发明还包括向处理部位施用液体的方法。 导管的远端位于治疗部位附近。 通过将大量液体放置在管腔中来对导管进行充电。 产生正压力以将推注剂驱动到施用尖端以从导管的远端表达推注。

公开(公告)号：US07565208B2

公开(公告)日：2009-07-21

申请号：US11037342

申请日：2005-01-19

申请人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

发明人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

IPC分类号： A61N1/02

CPC分类号： A61B5/4839 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/6885 ,  A61M25/0084

摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.

摘要翻译： 一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。 注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。 通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。 如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

公开(公告)号：US20090143748A1

公开(公告)日：2009-06-04

申请号：US12187439

申请日：2008-08-07

申请人： Timothy J. Mickley ,  Erik Sperry ,  Stephanie Webber ,  Chad Harris ,  Samuel J. Epstein ,  Grace Kim

发明人： Timothy J. Mickley ,  Erik Sperry ,  Stephanie Webber ,  Chad Harris ,  Samuel J. Epstein ,  Grace Kim

IPC分类号： A61M25/06 ,  A61M25/00

CPC分类号： A61M25/0084 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2018/00392

摘要： A catheter device includes an elongate tubular housing, a cannula, and a flexible proboscis. The cannula defines a cannula lumen which is in fluid communication with a cannula exit port located adjacent the distal end of the elongate housing. The distal tip of the cannula is disposed within the cannula lumen. The cannula defines a proboscis lumen and the cannula has a proboscis exit port in fluid communication with the proboscis lumen. The proboscis exit port is located at the distal tip of the cannula. The flexible proboscis has a distal tip and is disposed within the proboscis lumen.

摘要翻译： 导管装置包括细长管状外壳，套管和柔性长鼻子。 套管限定套管腔，其与位于细长壳体的远端附近的套管出口相流体连通。 套管的远端设置在套管腔内。 套管限定了长鼻腔，并且套管具有与长鼻腔流体连通的长鼻出口。 长鼻子出口位于套管的远端。 柔性长鼻具有远端尖端并且设置在长鼻腔内。

公开(公告)号：US07470252B2

公开(公告)日：2008-12-30

申请号：US10942046

申请日：2004-09-16

申请人： Timothy J. Mickley ,  Maria Palasis ,  Toby Freyman

发明人： Timothy J. Mickley ,  Maria Palasis ,  Toby Freyman

IPC分类号： A61M29/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/104 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1072

摘要： The present invention provides a systems that delivers therapeutic to the inner lumens, chambers, cavities, and vessels of the body. A therapeutic delivery device for delivery of therapeutic to a target site within the body of a patient is provided. This device may include a catheter, an expandable multi-port housing fluidly coupled to the catheter and a sheath. The multi-port housing in this device may be sized to travel within a lumen of a patient and may be adapted to expand from a first configuration to a second configuration. The multi-port housing may also contain at least two ejection ports coupled to an internal lumen of the multi-port housing.

摘要翻译： 本发明提供了将治疗剂递送到身体的内腔，腔室，空腔和血管的系统。 提供了用于将治疗剂递送到患者体内的靶位点的治疗递送装置。 该装置可以包括导管，可流体地联接到导管的可扩展多端口壳体和护套。 该装置中的多端口壳体的尺寸可以设计成在患者的内腔内行进，并且可以适于从第一构型扩展到第二构造。 多端口壳体还可以包含联接到多端口壳体的内腔的至少两个喷射端口。

公开(公告)号：US20080183143A1

公开(公告)日：2008-07-31

申请号：US12022413

申请日：2008-01-30

申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

IPC分类号： A61M31/00 ,  A61M29/00

CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

公开(公告)号：US20080147007A1

公开(公告)日：2008-06-19

申请号：US11612542

申请日：2006-12-19

申请人： Toby FREYMAN ,  Timothy J. Mickley

发明人： Toby FREYMAN ,  Timothy J. Mickley

IPC分类号： A61M1/00 ,  B65D71/00

CPC分类号： A61M5/14526 ,  A61M5/14593 ,  A61M5/16881

摘要： Delivery devices with pressure control mechanisms are described herein. In some embodiments an apparatus includes a reservoir configured to contain a fluid, the reservoir having an inlet port and an outlet port. A plunger is disposed within the reservoir such that the reservoir is divided into a first portion and a second portion. The inlet port is in fluid communication with the first portion of the reservoir, and the outlet port is in fluid communication with the second portion of the reservoir. A pressure control device configured to control a pressure of the fluid within the first portion of the reservoir is in fluid communication with the first portion of the reservoir.

摘要翻译： 具有压力控制机构的输送装置在这里被描述。 在一些实施例中，一种装置包括构造成容纳流体的储存器，储存器具有入口端口和出口。 柱塞被设置在储存器内，使得储存器被分成第一部分和第二部分。 入口与储存器的第一部分流体连通，并且出口与储存器的第二部分流体连通。 被配置为控制储存器的第一部分内的流体的压力的压力控制装置与储存器的第一部分流体连通。

公开(公告)号：US06802824B2

公开(公告)日：2004-10-12

申请号：US10171539

申请日：2002-06-17

申请人： Timothy J. Mickley ,  Bruce Arthur Christie ,  Douglas F. Walker ,  Jeremy L. Connell

发明人： Timothy J. Mickley ,  Bruce Arthur Christie ,  Douglas F. Walker ,  Jeremy L. Connell

IPC分类号： A61M5178

CPC分类号： A61M25/0136 ,  A61M25/0084 ,  A61M2025/0089

摘要： A catheter handpiece apparatus and method for delivering a desired dose with minimal potential for contamination of the injected substance and rapid, accurate delivery of the desired dose. In one embodiment, a carriage assembly affixed to an inner lumen is slidably located within a handpiece housing equipped with an outer lumen. The carriage assembly receives a dose carpule. An actuator knob cocks the carriage assembly and a spring-powered actuator mechanism. After the catheter is maneuvered to a desired injection site and a desired dose is set, depressing a first trigger causes the inner lumen tip to extend beyond the outer lumen into the injection site. Depressing a second trigger causes the actuator mechanism to push the desired dose from the dose carpule through the inner lumen into the injection site. A second embodiment provides a catheter handpiece with a carriage assembly cocking lever and an operator-powered dose delivery mechanism.

摘要翻译： 一种导管手持装置和方法，用于以最小的污染所注射物质的潜力来递送期望的剂量，并快速准确地输送所需剂量。 在一个实施例中，固定到内腔的托架组件可滑动地位于配备有外腔的手持壳体内。 托架组件接收剂量卡粒。 执行器旋钮使托架组件和弹簧动力致动器机构旋转。 在将导管操纵到期望的注射部位并设定期望的剂量之后，按下第一触发器将使内腔尖端延伸超出外腔进入注射部位。 按下第二个触发器使得致动器机构将期望的剂量从剂量小丸通过内腔推入注射部位。 第二实施例提供具有托架组件起动杆和操作者动力的剂量递送机构的导管手柄。

公开(公告)号：US06613017B1

公开(公告)日：2003-09-02

申请号：US09633924

申请日：2000-08-08

申请人： Timothy J. Mickley

发明人： Timothy J. Mickley

IPC分类号： A61M500

CPC分类号： A61M25/0084 ,  A61M25/0069 ,  A61M2025/0089

摘要： A catheter adapted to deliver therapeutic or diagnostic agents to a target tissue of a human body is disclosed. A catheter in accordance with the present invention comprises a first elongate shaft having a proximal end, a distal end, and a lumen extending therethrough, a second elongate shaft disposed within the lumen of the first elongate shaft, the first elongate shaft including a first helical member comprising a plurality of turns, the second elongate shaft including a second helical member comprising a plurality of turns.

摘要翻译： 公开了适于将治疗剂或诊断剂递送到人体的靶组织的导管。 根据本发明的导管包括具有近端，远端和延伸通过其的内腔的第一细长轴，设置在第一细长轴的内腔内的第二细长轴，第一细长轴包括第一螺旋 构件包括多个匝，所述第二细长轴包括包括多个匝的第二螺旋构件。

公开(公告)号：US6113579A

公开(公告)日：2000-09-05

申请号：US34421

申请日：1998-03-04

申请人： Tracee E. J. Eidenschink ,  Timothy J. Mickley ,  Christopher R. Larson ,  Steven P. Mertens ,  Charles L. Euteneuer

发明人： Tracee E. J. Eidenschink ,  Timothy J. Mickley ,  Christopher R. Larson ,  Steven P. Mertens ,  Charles L. Euteneuer

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M25/04 ,  A61M5/00 ,  A61M29/00

CPC分类号： A61M25/0068 ,  A61M25/0074 ,  A61M25/008 ,  A61M2025/0081 ,  A61M2025/1093 ,  A61M25/04 ,  A61M25/10

摘要： A catheter is disclosed which includes an over-the-wire type balloon catheter with a guide wire wherein the catheter includes a polyethylene inner tube and an outer tube having a relatively stiff proximal outer section, a midshaft section of lesser stiffness, and a tapering distal outer section of the least stiffness. An inflatable balloon is connected to the distal ends of the inner tube and the outer tube. The guide wire may be removed from and inserted into the guide wire lumen at either end of the catheter.

摘要翻译： 公开了一种导管，其包括具有导丝的超线型气囊导管，其中导管包括聚乙烯内管和具有相对刚性的近端外部部分的外管，具有较小刚度的中轴部分和锥形远端 外截面刚度最小。 可膨胀气囊连接到内管和外管的远端。 导丝可以从导管的任一端移除并插入导丝管内。