公开(公告)号：US20160084766A1

公开(公告)日：2016-03-24

申请号：US14861570

申请日：2015-09-22

Applicant: Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia

Inventor： Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia

IPC: G01N21/65 ,  G01N21/64 ,  B01L3/00

CPC classification number: G01N33/146 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/16 ,  G01J3/0218 ,  G01N21/05 ,  G01N21/64 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/651 ,  G01N2201/0846

Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.

Abstract translation: 一种拉曼光谱检测装置，包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。

公开(公告)号：US20140073027A1

公开(公告)日：2014-03-13

申请号：US14110384

申请日：2012-06-20

Applicant: Kishan Dholakia ,  Robert Marchington ,  Yoshihiko Arita ,  Frank Gunn-Moore

Inventor： Kishan Dholakia ,  Robert Marchington ,  Yoshihiko Arita ,  Frank Gunn-Moore

IPC: C12M1/42 ,  C12N13/00

CPC classification number: C12M35/02 ,  B01L3/502715 ,  B01L3/502761 ,  C12N13/00 ,  G01N21/05 ,  G01N2021/0346

Abstract: A cell permeabilizing micro fluidic system for permeabilizing one or more cells in a fluid flow. The system has a micro fluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.

Abstract translation: 一种用于使流体流中的一个或多个细胞渗透的细胞渗透微流体系统。 所述系统具有微流体通道，用于引导流体流中的至少一个电池，以及用于产生用于透化所述至少一个电池的光束的光源，其中所述通道和所述源被布置成使得所述光束和流体 流动在通道的透化部分中共线，并且细胞在透化部分内透化。

公开(公告)号：US08655178B2

公开(公告)日：2014-02-18

申请号：US13367769

申请日：2012-02-07

Applicant: Barbara A. Capron ,  William A. McNeely ,  Kishan Dholakia ,  Antonia Erika Carruthers

Inventor： Barbara A. Capron ,  William A. McNeely ,  Kishan Dholakia ,  Antonia Erika Carruthers

IPC: H04B10/00 ,  H04B10/02

CPC classification number: H04B10/112

Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.

Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束，其中光束具有空间和/或时间依赖的调制强度分布，并且基本准直，使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓，其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型，选择光源波长和强度，由此辐射压力作用在颗粒上，然后可以将颗粒从空间调制的光束的部分吸引或排斥，留下某些部分的 光通道光束不存在晦暗的颗粒，从而能够以低衰减通过清除光信道传输光学数据。

公开(公告)号：US20130107273A1

公开(公告)日：2013-05-02

申请号：US13643036

申请日：2011-06-02

Applicant: Kishan Dholakia ,  Mario Ettore Giardini

Inventor： Kishan Dholakia ,  Mario Ettore Giardini

IPC: G01B9/02

CPC classification number: G01B9/02091 ,  G01N21/474 ,  G01N21/4795 ,  G01N2021/4709

Abstract: An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.

Abstract translation: 一种光学相干断层摄影系统，包括光源（a）和探头（e），所述探头（e）在前面朝上的端部具有窗口。 窗口具有内表面（i），其具有防反射表面并且允许来自源的光通过它，以及外表面（j），其反射来自源的一些光并将一些光透射到 和样品（k）。 反射光作为参考。

公开(公告)号：US20120134682A1

公开(公告)日：2012-05-31

申请号：US13367769

申请日：2012-02-07

Applicant: Barbara A. Capron ,  William A. McNeely ,  Kishan Dholakia ,  Antonia Erika Carruthers

Inventor： Barbara A. Capron ,  William A. McNeely ,  Kishan Dholakia ,  Antonia Erika Carruthers

IPC: H04B10/00

CPC classification number: H04B10/112

Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.

Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束，其中光束具有空间和/或时间依赖的调制强度分布，并且基本准直，使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓，其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型，选择光源波长和强度，由此辐射压力作用在颗粒上，然后可以将颗粒从空间调制的光束的部分吸引或排斥，留下某些部分的 光通道光束不存在晦暗的颗粒，从而能够以低衰减通过清除光信道传输光学数据。

公开(公告)号：US20100032555A1

公开(公告)日：2010-02-11

申请号：US12442325

申请日：2007-09-20

Applicant: Michael MacDonald ,  Kishan Dholakia ,  Daniel Rhodes ,  Graham Milne

Inventor： Michael MacDonald ,  Kishan Dholakia ,  Daniel Rhodes ,  Graham Milne

IPC: G01N30/00

CPC classification number: G01N15/0205 ,  G01N1/40 ,  G01N2015/149 ,  G02B21/32

Abstract: A method for sorting particles in a fluid. The method involves generating an optical landscape using an acousto-optic device. Preferably, the optical landscape is arranged to sort particles based on size or refractive index or shape.

Abstract translation: 用于分选流体中的颗粒的方法。 该方法涉及使用声光装置产生光学景观。 优选地，光学景观布置成基于尺寸或折射率或形状对颗粒进行分类。

公开(公告)号：US20080279558A1

公开(公告)日：2008-11-13

申请号：US12036975

申请日：2008-02-25

Applicant: Barbara A. Capron ,  William A. McNeely ,  Kishan Dholakia ,  Antonia Erika Carruthers

Inventor： Barbara A. Capron ,  William A. McNeely ,  Kishan Dholakia ,  Antonia Erika Carruthers

IPC: H04B10/00

CPC classification number: H04B10/112

Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.

Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束，其中光束具有空间和/或时间依赖的调制强度分布，并且基本准直，使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓，其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型，选择光源波长和强度，由此辐射压力作用在颗粒上，然后可以将颗粒从空间调制的光束的部分吸引或排斥，留下某些部分的 光通道光束不存在晦暗的颗粒，从而能够以低衰减通过清除光信道传输光学数据。

公开(公告)号：US07173711B2

公开(公告)日：2007-02-06

申请号：US10451576

申请日：2001-12-18

Applicant: Kishan Dholakia ,  Michael Peter Macdonald ,  Jochen Arlt

Inventor： Kishan Dholakia ,  Michael Peter Macdonald ,  Jochen Arlt

IPC: G01B9/02

CPC classification number: H05H3/04 ,  G21K1/006

Abstract: Apparatus for and a method of rotating microscopic objects uses a beam of electromagnetic radiation. A microscopic, non-circularly symmetric distribution of electro-magnetic radiation is projected on to a region containing an object to be rotated so as to cause photons in the beam to refract around the objects. Rotating means then rotate that distribution and so rotate the objects. The distribution may be formed on the interference pattern between a beam having a Laguerre-Gaussian wave fronts and either a plane wave or a further Laguerre-Gaussian beam of opposite helicity.

Abstract translation: 用于旋转微观物体的装置和方法使用电磁辐射束。 将电磁辐射的微观非圆对称分布投影到包含要旋转的物体的区域上，以使光束中的光子折射到物体周围。 然后，旋转装置旋转该分布并因此旋转物体。 该分布可以形成在具有拉格尔 - 高斯波阵面的波束和具有相反螺旋度的平面波或另一拉格尔 - 高斯波束之间的干涉图案上。