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公开(公告)号:US09683209B2
公开(公告)日:2017-06-20
申请号:US14110384
申请日:2012-06-20
Applicant: Kishan Dholakia , Robert Marchington , Yoshihiko Arita , Frank Gunn-Moore
Inventor: Kishan Dholakia , Robert Marchington , Yoshihiko Arita , Frank Gunn-Moore
CPC classification number: C12M35/02 , B01L3/502715 , B01L3/502761 , C12N13/00 , G01N21/05 , G01N2021/0346
Abstract: A cell permeabilizing microfluidic system for permeabilizing one or more cells in a fluid flow. The system has a microfluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.
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公开(公告)号:US08922767B2
公开(公告)日:2014-12-30
申请号:US12303526
申请日:2007-06-08
Applicant: Kishan Dholakia , Phillip Ronald Thomas Jess , Michael Mazilu
Inventor: Kishan Dholakia , Phillip Ronald Thomas Jess , Michael Mazilu
CPC classification number: G01J3/0297 , B01L3/5027 , G01J3/28 , G01J3/433 , G01J3/44 , G01J3/4412 , G01N21/65 , G01N2021/651 , G01N2021/656
Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle while it is in the optical trap.
Abstract translation: 一种微流体系统,包括用于光学捕获颗粒和拉曼激发源的装置,用于在所述光阱中引起来自所述颗粒的拉曼散射。
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公开(公告)号:US20130222799A1
公开(公告)日:2013-08-29
申请号:US13818501
申请日:2011-09-28
Applicant: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Inventor: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
IPC: G01J3/02
CPC classification number: G01N33/146 , B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0883 , B01L2300/16 , G01J3/0218 , G01N21/05 , G01N21/64 , G01N21/645 , G01N21/65 , G01N2021/651 , G01N2201/0846
Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
Abstract translation: 一种拉曼光谱检测装置,包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。
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公开(公告)号:US09417457B2
公开(公告)日:2016-08-16
申请号:US13640453
申请日:2011-04-13
Applicant: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
Inventor: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.
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公开(公告)号:US20160084766A1
公开(公告)日:2016-03-24
申请号:US14861570
申请日:2015-09-22
Applicant: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Inventor: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
CPC classification number: G01N33/146 , B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0883 , B01L2300/16 , G01J3/0218 , G01N21/05 , G01N21/64 , G01N21/645 , G01N21/65 , G01N2021/651 , G01N2201/0846
Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
Abstract translation: 一种拉曼光谱检测装置,包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。
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公开(公告)号:US09274335B2
公开(公告)日:2016-03-01
申请号:US14233105
申请日:2012-09-13
Applicant: Kishan Dholakia , Tomas Cizmar
Inventor: Kishan Dholakia , Tomas Cizmar
CPC classification number: G02B27/0025 , G01J1/02 , G02B26/06 , G02B27/0933
Abstract: Methods for controlling light transmission through a medium by transmitting light from a single spatial portion of an input optical field through the medium creating an output optical field, superposing the output optical field with a reference optical field creating an optical interference field, detecting an intensity of a spatial portion of a polarization component of the optical interference field and using the detected intensity to determine a value of an optical field amplitude and of an optical field phase for each of a plurality of spatial portions of the input optical field and for each of first and second orthogonal input polarization states of transmitted light entering the medium. The method may be used in the control of the transmission of light 1) through a medium, which is randomizing in amplitude, phase and/or polarization or 2) through a multi-mode fiber or for beam shaping, optical trapping and/or optical manipulation.
Abstract translation: 用于通过从输入光场的单个空间部分传输光通过介质来控制光传输的方法,其创建输出光场,将输出光场与参考光场叠加,产生光学干涉场,检测光强 光学干涉场的偏振分量的空间部分,并且使用所检测的强度来确定输入光场的多个空间部分中的每一个的光场振幅和光场相位的值,并且对于第一 以及进入介质的透射光的第二正交输入极化状态。 该方法可以用于控制通过介质的光的传输1),该介质在幅度,相位和/或极化上是随机化的,或者2)通过多模光纤或用于光束成形,光学俘获和/或光学 操纵。
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公开(公告)号:US20140073027A1
公开(公告)日:2014-03-13
申请号:US14110384
申请日:2012-06-20
Applicant: Kishan Dholakia , Robert Marchington , Yoshihiko Arita , Frank Gunn-Moore
Inventor: Kishan Dholakia , Robert Marchington , Yoshihiko Arita , Frank Gunn-Moore
CPC classification number: C12M35/02 , B01L3/502715 , B01L3/502761 , C12N13/00 , G01N21/05 , G01N2021/0346
Abstract: A cell permeabilizing micro fluidic system for permeabilizing one or more cells in a fluid flow. The system has a micro fluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.
Abstract translation: 一种用于使流体流中的一个或多个细胞渗透的细胞渗透微流体系统。 所述系统具有微流体通道,用于引导流体流中的至少一个电池,以及用于产生用于透化所述至少一个电池的光束的光源,其中所述通道和所述源被布置成使得所述光束和流体 流动在通道的透化部分中共线,并且细胞在透化部分内透化。
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公开(公告)号:US08655178B2
公开(公告)日:2014-02-18
申请号:US13367769
申请日:2012-02-07
Applicant: Barbara A. Capron , William A. McNeely , Kishan Dholakia , Antonia Erika Carruthers
Inventor: Barbara A. Capron , William A. McNeely , Kishan Dholakia , Antonia Erika Carruthers
CPC classification number: H04B10/112
Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.
Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束,其中光束具有空间和/或时间依赖的调制强度分布,并且基本准直,使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓,其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型,选择光源波长和强度,由此辐射压力作用在颗粒上,然后可以将颗粒从空间调制的光束的部分吸引或排斥,留下某些部分的 光通道光束不存在晦暗的颗粒,从而能够以低衰减通过清除光信道传输光学数据。
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公开(公告)号:US20130107273A1
公开(公告)日:2013-05-02
申请号:US13643036
申请日:2011-06-02
Applicant: Kishan Dholakia , Mario Ettore Giardini
Inventor: Kishan Dholakia , Mario Ettore Giardini
IPC: G01B9/02
CPC classification number: G01B9/02091 , G01N21/474 , G01N21/4795 , G01N2021/4709
Abstract: An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.
Abstract translation: 一种光学相干断层摄影系统,包括光源(a)和探头(e),所述探头(e)在前面朝上的端部具有窗口。 窗口具有内表面(i),其具有防反射表面并且允许来自源的光通过它,以及外表面(j),其反射来自源的一些光并将一些光透射到 和样品(k)。 反射光作为参考。
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公开(公告)号:US20120134682A1
公开(公告)日:2012-05-31
申请号:US13367769
申请日:2012-02-07
Applicant: Barbara A. Capron , William A. McNeely , Kishan Dholakia , Antonia Erika Carruthers
Inventor: Barbara A. Capron , William A. McNeely , Kishan Dholakia , Antonia Erika Carruthers
IPC: H04B10/00
CPC classification number: H04B10/112
Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.
Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束,其中光束具有空间和/或时间依赖的调制强度分布,并且基本准直,使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓,其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型,选择光源波长和强度,由此辐射压力作用在颗粒上,然后可以将颗粒从空间调制的光束的部分吸引或排斥,留下某些部分的 光通道光束不存在晦暗的颗粒,从而能够以低衰减通过清除光信道传输光学数据。
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