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公开(公告)号:US20130107273A1
公开(公告)日:2013-05-02
申请号:US13643036
申请日:2011-06-02
Applicant: Kishan Dholakia , Mario Ettore Giardini
Inventor: Kishan Dholakia , Mario Ettore Giardini
IPC: G01B9/02
CPC classification number: G01B9/02091 , G01N21/474 , G01N21/4795 , G01N2021/4709
Abstract: An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.
Abstract translation: 一种光学相干断层摄影系统,包括光源(a)和探头(e),所述探头(e)在前面朝上的端部具有窗口。 窗口具有内表面(i),其具有防反射表面并且允许来自源的光通过它,以及外表面(j),其反射来自源的一些光并将一些光透射到 和样品(k)。 反射光作为参考。
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公开(公告)号:US09816802B2
公开(公告)日:2017-11-14
申请号:US13643036
申请日:2011-06-02
Applicant: Kishan Dholakia , Mario Ettore Giardini
Inventor: Kishan Dholakia , Mario Ettore Giardini
CPC classification number: G01B9/02091 , G01N21/474 , G01N21/4795 , G01N2021/4709
Abstract: An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.
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公开(公告)号:US09683209B2
公开(公告)日:2017-06-20
申请号:US14110384
申请日:2012-06-20
Applicant: Kishan Dholakia , Robert Marchington , Yoshihiko Arita , Frank Gunn-Moore
Inventor: Kishan Dholakia , Robert Marchington , Yoshihiko Arita , Frank Gunn-Moore
CPC classification number: C12M35/02 , B01L3/502715 , B01L3/502761 , C12N13/00 , G01N21/05 , G01N2021/0346
Abstract: A cell permeabilizing microfluidic system for permeabilizing one or more cells in a fluid flow. The system has a microfluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.
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公开(公告)号:US08922767B2
公开(公告)日:2014-12-30
申请号:US12303526
申请日:2007-06-08
Applicant: Kishan Dholakia , Phillip Ronald Thomas Jess , Michael Mazilu
Inventor: Kishan Dholakia , Phillip Ronald Thomas Jess , Michael Mazilu
CPC classification number: G01J3/0297 , B01L3/5027 , G01J3/28 , G01J3/433 , G01J3/44 , G01J3/4412 , G01N21/65 , G01N2021/651 , G01N2021/656
Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle while it is in the optical trap.
Abstract translation: 一种微流体系统,包括用于光学捕获颗粒和拉曼激发源的装置,用于在所述光阱中引起来自所述颗粒的拉曼散射。
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公开(公告)号:US20130222799A1
公开(公告)日:2013-08-29
申请号:US13818501
申请日:2011-09-28
Applicant: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Inventor: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
IPC: G01J3/02
CPC classification number: G01N33/146 , B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0883 , B01L2300/16 , G01J3/0218 , G01N21/05 , G01N21/64 , G01N21/645 , G01N21/65 , G01N2021/651 , G01N2201/0846
Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
Abstract translation: 一种拉曼光谱检测装置,包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。
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公开(公告)号:US10222362B2
公开(公告)日:2019-03-05
申请号:US14861570
申请日:2015-09-22
Applicant: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Inventor: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
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公开(公告)号:US09957476B2
公开(公告)日:2018-05-01
申请号:US13639296
申请日:2011-04-11
Applicant: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
Inventor: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
CPC classification number: C12N5/0006 , C12M35/02 , C12N15/87
Abstract: A method for porating one or more cells comprising positioning a particle near each cell; and causing laser-induced breakdown of the particle to create one or more cavitations, wherein the cavitation(s) causes poration of the cell.
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公开(公告)号:US09815058B2
公开(公告)日:2017-11-14
申请号:US10554937
申请日:2004-05-07
Applicant: Michael Peter MacDonald , Kishan Dholakia , Steven Leonard Neale , Gabriel Cooper Spalding
Inventor: Michael Peter MacDonald , Kishan Dholakia , Steven Leonard Neale , Gabriel Cooper Spalding
CPC classification number: B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N15/1434 , G01N15/1459 , G01N2015/145 , G01N2015/149 , G01N30/02 , B01D2015/3895
Abstract: A fractionation system comprising means for forming a three dimensional optical lattice that is operable to separate particles that have different physical characteristics. Preferably, the wells of the optical lattice are interlinked. For example, the wells may be linked in such a manner as to provide deflection greater than or equal to 15 degrees.
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公开(公告)号:US20130173194A1
公开(公告)日:2013-07-04
申请号:US13640453
申请日:2011-04-13
Applicant: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
Inventor: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
IPC: G06F17/11
CPC classification number: G02B27/58 , G02B2207/125
Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.
Abstract translation: 一种优化作为波函数的二次函数的至少一个度量的方法,例如激光器的光斑尺寸,该方法包括:叠加多个波函数; 确定叠加的波函数和二次测量之间的关系,并且使用确定的关系来识别提供期望或优化的二次方法的叠加波函数。
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公开(公告)号:US20130113140A1
公开(公告)日:2013-05-09
申请号:US13639296
申请日:2011-04-11
Applicant: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
Inventor: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
IPC: C12N5/00
CPC classification number: C12N5/0006 , C12M35/02 , C12N15/87
Abstract: A method for porating one or more cells comprising positioning a particle near each cell; and causing laser-induced breakdown of the particle to create one or more cavitations, wherein the cavitation(s) causes poration of the cell.
Abstract translation: 一种用于对一个或多个单元进行加工的方法,包括将颗粒定位在每个单元附近; 并引起激光诱发的颗粒破坏以产生一个或多个空化,其中空化引起细胞的扩孔。
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