公开(公告)号：US20060211007A1

公开(公告)日：2006-09-21

申请号：US11219506

申请日：2005-09-01

Applicant: Virginia Cornish ,  Michael Sheetz ,  Larry Miller

Inventor： Virginia Cornish ,  Michael Sheetz ,  Larry Miller

IPC: C12Q1/68 ,  G01N33/53 ,  C12Q1/26

CPC classification number: G01N33/582 ,  C12Q1/025 ,  C12Q1/32 ,  G01N33/5005 ,  G01N33/573 ,  G01N2333/906 ,  G01N2500/10

Abstract: The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A “target” molecule is linked to a detector molecule (such as a protein or a nucleic acid) and the function and/or location of the target molecule is monitored by binding the detector molecule its ligand, which carries a detectable label. In particular embodiments of the invention, an intracellular fusion protein comprising a target protein and a detector protein is bound to a membrane-permeable, fluorescently-labeled ligand of the detector protein, thereby providing an adjunct or alternative to Green Fluorescent Protein.

公开(公告)号：US20050261693A1

公开(公告)日：2005-11-24

申请号：US11190331

申请日：2005-07-27

Applicant: Larry Miller ,  David Bolleter ,  Charles Schwimmer ,  Robert Wilk

Inventor： Larry Miller ,  David Bolleter ,  Charles Schwimmer ,  Robert Wilk

IPC: A61B17/00 ,  A61B17/32 ,  A61B17/34 ,  A61B19/00 ,  A61M5/31 ,  A61M5/315 ,  A61M5/34

CPC classification number: A61M5/1454 ,  A61B17/32002 ,  A61B17/32053 ,  A61B17/3403 ,  A61B17/3472 ,  A61B17/3476 ,  A61B90/11 ,  A61B2017/3413 ,  A61B2090/034 ,  A61M5/158 ,  A61M5/2033 ,  A61M5/24 ,  A61M5/31511 ,  A61M5/3291 ,  A61M5/34 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2005/3103 ,  A61M2005/3289 ,  A61M2210/02

Abstract: Apparatus for delivering a quantity of fluid to bone marrow of a bone or providing access to remove fluids from a target site is provided. The apparatus may include a driver, a plunger operating and cartridge assembly mechanism, a cartridge assembly having a fluid reservoir and a bone penetrating needle.

Abstract translation: 提供了用于将一定量的流体输送到骨的骨髓或提供从目标部位去除流体的通道的装置。 该装置可以包括驱动器，柱塞操作和盒组件机构，具有流体储存器和骨穿透针的盒组件。

公开(公告)号：US20050253453A1

公开(公告)日：2005-11-17

申请号：US10847169

申请日：2004-05-17

Applicant: Larry Miller

Inventor： Larry Miller

IPC: B60B9/00 ,  B62D55/096 ,  B62D55/14 ,  B62D55/21 ,  B62D55/26 ,  B62D55/30

CPC classification number: B62D55/0966 ,  B62D55/145 ,  B62D55/21 ,  B62D55/26 ,  B62D55/30

Abstract: A crawler-dozer has a track assembly that includes an idler wheel with an elastomeric ring extending around its outer surface. The ring is continuous, having no breaks in its periphery that permit it to fall off. The ring is not held onto the idler wheel by fasteners but by being force fit on or molded around the periphery of the idler wheel. The ring may be inhomogeneous, having different hardnesses or having reinforcing materials embedded in an elastomeric matrix.

Abstract translation: 履带式推土机具有轨道组件，其包括具有围绕其外表面延伸的弹性体环的惰轮。 环是连续的，其周边没有断裂，允许其脱落。 环不通过紧固件固定在惰轮上，而是通过紧配合在惰轮的周边上或模制在惰轮周围。 该环可能不均匀，具有不同的硬度或具有嵌入弹性体基质中的增强材料。

公开(公告)号：US20050192368A1

公开(公告)日：2005-09-01

申请号：US10887006

申请日：2004-07-08

Applicant: Larry Miller ,  Raymond Breindel ,  Mitchell Weekley ,  Thomas Cisar

Inventor： Larry Miller ,  Raymond Breindel ,  Mitchell Weekley ,  Thomas Cisar

IPC: C08J9/04 ,  B29C44/34 ,  B29C47/00 ,  B29K25/00 ,  B29K101/12 ,  B29K105/04 ,  C08F2/00 ,  C08J9/12 ,  C08J9/32

CPC classification number: C08J9/146 ,  B29C44/3403 ,  B29C44/352 ,  C08J9/12 ,  C08J9/122 ,  C08J9/142 ,  C08J9/144 ,  C08J2205/04 ,  C08J2325/06

Abstract: This invention relates to foam insulating products, particularly extruded polystyrene foam, with increasing the cell orientation and reducing cell anisotropic ratio, as well as the process method for making the products thereof for improving the insulating properties and for reducing the manufacturing cost of the foam products. Alternatively, foam insulating products having increased cell compressive strength may be made by decreasing the cell orientation and increasing the cell anisotropic ratio.

Abstract translation: 本发明涉及泡沫绝缘产品，特别是挤出聚苯乙烯泡沫，随着电池取向的增加和电池各向异性比的降低，以及制造其产品的方法，用于提高绝缘性能和降低泡沫产品的制造成本 。 或者，可以通过减小电池取向和增加电池各向异性比例来制造具有增加的电池抗压强度的泡沫绝缘产品。

公开(公告)号：US20050131345A1

公开(公告)日：2005-06-16

申请号：US10987051

申请日：2004-11-12

Applicant: Larry Miller

Inventor： Larry Miller

IPC: A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/16 ,  A61B17/32 ,  A61B17/34 ,  A61B19/00 ,  A61M1/00 ,  A61M5/158 ,  A61M5/46 ,  A61M5/00

CPC classification number: A61B17/32002 ,  A61B10/025 ,  A61B10/0283 ,  A61B17/1637 ,  A61B17/1691 ,  A61B17/32053 ,  A61B17/3472 ,  A61B17/3476 ,  A61B90/11 ,  A61B90/70 ,  A61B2010/0208 ,  A61B2010/0258 ,  A61B2017/00398 ,  A61B2017/0046 ,  A61B2017/00734 ,  A61B2017/320024 ,  A61B2090/034 ,  A61B2090/036 ,  A61B2090/0813 ,  A61B2217/005 ,  A61M5/158 ,  A61M5/46 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2210/02

Abstract: An apparatus and method for accessing the bone marrow of a human's sternum is provided. The apparatus includes a tissue penetrator configured to penetrate the sternum, a trigger mechanism configured to engage when the tissue penetrator contacts the sternum and a depth control mechanism operable to limit the penetration of the tissue penetrator into the sternum to a pre-selected depth.

Abstract translation: 提供了一种用于进入人体胸骨骨髓的装置和方法。 该装置包括构造成穿透胸骨的组织穿透器，构造成当组织穿透器接触胸骨时接合的触发器机构以及可操作以将组织穿透器穿入胸骨的深度控制到预选深度的深度控制机构。

公开(公告)号：US06275268B1

公开(公告)日：2001-08-14

申请号：US09368198

申请日：1999-08-04

Applicant: Michael Dean Ellis ,  Bruce Davis ,  Edward Bruce Knudson ,  Larry Miller

Inventor： Michael Dean Ellis ,  Bruce Davis ,  Edward Bruce Knudson ,  Larry Miller

IPC: H04N550

CPC classification number: H04N5/44543 ,  A63F13/12 ,  A63F2300/409 ,  G06Q10/087 ,  H04N5/445 ,  H04N5/50 ,  H04N7/0884 ,  H04N7/0887 ,  H04N7/163 ,  H04N7/165 ,  H04N7/17318 ,  H04N7/17354 ,  H04N21/4345 ,  H04N21/4524 ,  H04N21/47 ,  H04N21/472 ,  H04N21/47211 ,  H04N21/47214 ,  H04N21/4753 ,  H04N21/4755 ,  H04N21/482 ,  H04N21/84 ,  H04N21/8586

Abstract: An electronic program schedule system with product ordering capability which includes a data processor for receiving program schedule information for a plurality of programs, and a user control apparatus, such as a remote controller, for generating user control commands and transmitting signals to the data processor in response thereto. The television program schedule information is displayed on a display apparatus such as a television receiver. A video display generator receives video control commands from the data processor and program schedule information and displays a portion of the program schedule information on the receiver. The program schedule information indicates the availability of a product or service for certain of the programs included in the program information, wherein the product or service is associated with the program, such as a program transcript or videocassette. The viewer utilizes the remote control apparatus to generate a first command for displaying information on the receiver describing the product or service, and a second command for placing an order for the product or service. The data processor receives the user control commands and in response to the first command causes the video display generator to display information describing the product or service and in response to the second command generates an order for the product or service.

Abstract translation: 一种具有产品订购能力的电子程序调度系统，其包括用于接收多个程序的程序调度信息的数据处理器，以及用于生成用户控制命令的用户控制装置，以及向数据处理器发送信号 回应。 电视节目安排信息被显示在诸如电视接收机的显示装置上。 视频显示生成器从数据处理器接收视频控制命令和节目安排信息，并且在接收器上显示节目安排信息的一部分。 节目时间表信息指示包括在节目信息中的某些节目的产品或服务的可用性，其中产品或服务与节目相关联，诸如节目转录或录像带。 观众利用遥控装置产生用于在描述产品或服务的接收器上显示信息的第一命令和用于对产品或服务下订单的第二命令。 数据处理器接收用户控制命令，并且响应于第一命令使视频显示生成器显示描述产品或服务的信息，并且响应于第二命令产生产品或服务的订单。

公开(公告)号：US5788609A

公开(公告)日：1998-08-04

申请号：US726762

申请日：1996-10-07

Applicant: Larry Miller

Inventor： Larry Miller

IPC: A63B23/035 ,  A63B23/04 ,  A63B69/16 ,  A63B22/04

CPC classification number: A63B22/001 ,  A63B21/00178 ,  A63B22/0023 ,  A63B22/0664 ,  A63B2022/0676 ,  A63B21/0051 ,  A63B21/012 ,  A63B21/225 ,  A63B22/203 ,  A63B2220/13 ,  A63B2220/20 ,  A63B2220/30 ,  A63B2230/75

Abstract: A compact exercise device includes a pair of crank arms pivotably supported on a frame for rotation about a pivot axis. Each crank arm engages a respective intermediate link at its first end. A second end of each intermediate link travels on a guide member so that as the crank arms rotates, the first end of each intermediate link traces an arcuate path, and the second end of each intermediate link traces a reciprocating path. The device includes a pair of foot links, each foot link is coupled, through a first end thereof, to a respective one of said intermediate links at a point between the first and second ends thereof; a second end of each foot link engages another guide member which directs it along a preselected path of travel, as the intermediate link is moved by the crank arm. The device provides a range of foot and leg motion simulating a natural running and stepping action.

公开(公告)号：US5611756A

公开(公告)日：1997-03-18

申请号：US636074

申请日：1996-04-22

Applicant: Larry Miller

Inventor： Larry Miller

IPC: A63B21/012 ,  A63B21/22 ,  A63B23/035 ,  A63B23/04 ,  A63B69/16 ,  A63B22/00

CPC classification number: A63B22/0664 ,  A63B21/00178 ,  A63B22/001 ,  A63B2022/0682 ,  A63B21/012 ,  A63B21/225 ,  A63B22/0015 ,  A63B2208/0204

Abstract: An exercise device includes a frame having a set of guide links pivotally supported thereupon. Each guide link supports a foot engaging link at one end thereof. The guide links are reciprocated back and forth by a set of intermediate links which engage a set of cranks which rotate about a second pivot point. A control link joins the foot link to the intermediate link and operates to vary the angle between the guide links and the foot links, as the guide links reciprocate. This device provides a very natural running and stepping action for a user who is positioned on the foot links.

Abstract translation: 锻炼装置包括具有枢转地支撑在其上的一组引导件的框架。 每个引导连杆在其一端支撑脚接合连杆。 导向连杆通过一组中间连杆来回往复运动，该中间连杆接合围绕第二枢转点转动的一组曲柄。 控制链路将脚连接件连接到中间链节，并且操作以随着引导件往复运动而改变导向连杆和脚部连接件之间的角度。 该设备为位于脚链路上的用户提供了非常自然的运行和步进动作。

公开(公告)号：US5589892A

公开(公告)日：1996-12-31

申请号：US476217

申请日：1995-06-07

Applicant: Robert A. Knee ,  Anthony R. Favia ,  Bruce Davis ,  Larry Miller

Inventor： Robert A. Knee ,  Anthony R. Favia ,  Bruce Davis ,  Larry Miller

IPC: A63F13/12 ,  G06Q10/08 ,  H04N5/445 ,  H04N5/50 ,  H04N7/025 ,  H04N7/03 ,  H04N7/035 ,  H04N7/08 ,  H04N7/081 ,  H04N7/088 ,  H04N7/16 ,  H04N7/173 ,  H04N21/431 ,  H04N21/434 ,  H04N21/45 ,  H04N21/454 ,  H04N21/47 ,  H04N21/472 ,  H04N21/475 ,  H04N21/478 ,  H04N21/482 ,  H04N21/488 ,  H04N21/81 ,  H04N21/84 ,  H04N21/858

CPC classification number: H04N21/482 ,  A63F13/12 ,  A63F13/338 ,  G06Q10/087 ,  H04N21/4312 ,  H04N21/4314 ,  H04N21/4345 ,  H04N21/4524 ,  H04N21/4532 ,  H04N21/454 ,  H04N21/47 ,  H04N21/472 ,  H04N21/47214 ,  H04N21/4753 ,  H04N21/4755 ,  H04N21/47815 ,  H04N21/4821 ,  H04N21/488 ,  H04N21/812 ,  H04N21/84 ,  H04N21/8586 ,  H04N5/44543 ,  H04N7/0884 ,  H04N7/0887 ,  H04N7/163 ,  H04N7/165 ,  H04N7/17318 ,  H04N7/17354 ,  A63F2300/409 ,  H04N5/445 ,  H04N5/50

Abstract: An electronic program schedule system with access to both stored television program schedule information and data feeds containing status information for live programs such as sporting events. The system includes a data processor for receiving program schedule information for a plurality of programs and data feeds containing status information for certain of the programs, and a video display generator for generating a display signal simultaneously comprising information from both the stored schedule information and the received data feed. The system is further provided with user control means such as a remote controller for generating user control commands and transmitting signals to the data processor in response thereto so as to control the content of the display signal. The display signal may be displayed on a display apparatus such as a television receiver. In addition, the program schedule system of the present invention utilizes category-specific user interfaces providing access to multiple services including television programs, received data feeds, home shopping services, and video games as well as the stored program schedule information.

公开(公告)号：US5518473A

公开(公告)日：1996-05-21

申请号：US407272

申请日：1995-03-20

Applicant: Larry Miller

Inventor： Larry Miller

IPC: A63B21/22 ,  A63B23/035 ,  A63B23/04 ,  A63B69/16 ,  A63B22/04

CPC classification number: A63B22/0664 ,  A63B2022/067 ,  A63B21/225 ,  A63B22/0046 ,  A63B2208/0204

Abstract: An exercise device includes a frame which supports a pair of foot links so that a first end of each foot link is pivotably coupled to the frame for motion about an arcuate path. A guide which is supported by the frame engages each foot link and directs a second end of each foot link along a closed, curved, generally teardrop shaped path of travel. This combination of motions defined by the foot link provides a natural running and stepping motion in which the heel of a user's foot initially rises faster than the toe as the foot move begins to forward and subsequently falls faster than the toe as the foot begins to move backward.

Abstract translation: 锻炼装置包括支撑一对脚连接件的框架，使得每个脚连杆的第一端可枢转地联接到框架以围绕弓形路径运动。 由框架支撑的导向件与每个脚连接件接合并且沿着闭合的，弯曲的，大体上泪珠状的行进路径引导每个脚连杆的第二端。 由脚部连接限定的运动的这种组合提供了一种自然的跑步和踏步运动，其中当脚部移动开始向前移动时，使用者的脚的脚跟起始比脚趾上升得更快，并随后随着足部开始移动而比脚趾下降得更快 落后。