公开(公告)号：US11229384B2

公开(公告)日：2022-01-25

申请号：US16203951

申请日：2018-11-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66 ,  A61M5/172

Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

公开(公告)号：US10660555B2

公开(公告)日：2020-05-26

申请号：US16419624

申请日：2019-05-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61B5/1459 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/053 ,  G01N33/66 ,  A61M5/172 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20200077930A1

公开(公告)日：2020-03-12

申请号：US16216838

申请日：2018-12-11

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486 ,  G01N27/327

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US20190269355A1

公开(公告)日：2019-09-05

申请号：US16419624

申请日：2019-05-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/053 ,  G01R35/00 ,  G01N33/66 ,  G01N27/416 ,  A61B5/00 ,  G01N33/96 ,  G01N33/49 ,  G01N27/02 ,  A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61B5/1486 ,  A61M5/158 ,  A61B5/1459 ,  A61B5/1473

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20190246960A1

公开(公告)日：2019-08-15

申请号：US16388794

申请日：2019-04-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/1473 ,  A61M5/142 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61M5/172

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4836 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/7271 ,  A61B2560/0276 ,  A61B2560/029 ,  A61M5/142 ,  A61M5/1723

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10327686B2

公开(公告)日：2019-06-25

申请号：US14980241

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/053

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10321865B2

公开(公告)日：2019-06-18

申请号：US15816559

申请日：2017-11-17

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Raghavendhar Gautham ,  Ning Yang ,  Rajiv Shah

IPC: A61B5/00 ,  A61B5/145 ,  G01N27/02 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/053 ,  G01N33/49 ,  G01N33/66 ,  G01N27/416 ,  G01R35/00 ,  A61M5/158 ,  A61M5/142 ,  A61M5/172 ,  G01N33/96

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20190094169A1

公开(公告)日：2019-03-28

申请号：US16200337

申请日：2018-11-26

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Qingling Yang ,  Robert C. Mucic ,  Jenn-Hann Larry Wang

IPC: G01N27/327 ,  C12Q1/00

Abstract: The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4′-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors.

公开(公告)号：US10188326B2

公开(公告)日：2019-01-29

申请号：US15272225

申请日：2016-09-21

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: G01N27/327 ,  C12Q1/00 ,  A61B5/145 ,  A61B5/1486

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US10172544B2

公开(公告)日：2019-01-08

申请号：US15701775

申请日：2017-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/172 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.