公开(公告)号：US12290360B2

公开(公告)日：2025-05-06

申请号：US17515587

申请日：2021-11-01

Applicant: Medtronic MiniMed, Inc.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G08B21/18

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US11931145B2

公开(公告)日：2024-03-19

申请号：US17542655

申请日：2021-12-06

Applicant: Medtronic MiniMed, Inc.

Inventor： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  A61M5/172 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/742 ,  A61M5/1723 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/66 ,  A61M2230/201 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7733 ,  G01N2021/775 ,  G01N2021/7759 ,  G01N2021/7786 ,  G01N2333/4724

Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

公开(公告)号：US20230017510A1

公开(公告)日：2023-01-19

申请号：US17892206

申请日：2022-08-22

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1473 ,  A61M5/142 ,  A61M5/172

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US11446108B2

公开(公告)日：2022-09-20

申请号：US15444252

申请日：2017-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Eric Allan Larson ,  Rajiv Shah

IPC: A61B5/00 ,  A61B50/30 ,  A61B5/1486 ,  A61B5/145 ,  A61L2/08 ,  A61M5/00 ,  B65B5/04 ,  B65B7/28 ,  B65B55/02 ,  B65D65/38 ,  B65D77/26 ,  B65B7/16 ,  B65B55/16 ,  B65D75/32 ,  A61B50/00

Abstract: A product allows gaseous manufacturing by-products to be vented from the inside a sealed package tray. An exemplary method for packaging a device includes sealing the device inside a package tray with a gas-permeable sealing material, resulting in a sealed package tray. The sealing material allows volatile substances to vent from inside the sealed package tray to outside the sealed package tray.

公开(公告)号：US11160477B2

公开(公告)日：2021-11-02

申请号：US16170901

申请日：2018-10-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01N27/02 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1459 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61M5/158 ,  A61M5/142 ,  G01R35/00 ,  A61B5/0537 ,  A61M5/172 ,  A61B5/0538 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10549036B2

公开(公告)日：2020-02-04

申请号：US15282731

申请日：2016-09-30

Applicant: Medtronic MiniMed, Inc.

Inventor： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

IPC: A61M5/172 ,  G06F19/00 ,  A61M5/142

Abstract: A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

公开(公告)号：US10426383B2

公开(公告)日：2019-10-01

申请号：US13779584

申请日：2013-02-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Ting Huang ,  Ashwin K. Rao ,  Rajiv Shah ,  Qingling Yang

IPC: A61B5/145 ,  A61B5/1477

Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US10327678B2

公开(公告)日：2019-06-25

申请号：US14247478

申请日：2014-04-08

Applicant: Medtronic MiniMed, Inc.

Inventor： Rebecca K. Gottlieb ,  Rajiv Shah ,  Eric A. Larson ,  Chia Chiu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  C12Q1/00

Abstract: Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US10288578B2

公开(公告)日：2019-05-14

申请号：US15851359

申请日：2017-12-21

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US10274349B2

公开(公告)日：2019-04-30

申请号：US14281770

申请日：2014-05-19

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Pratik Agrawal ,  Brian T. Kannard ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Yuxiang Zhong

IPC: A61M5/172 ,  G01D18/00 ,  G05B23/00 ,  A61M5/142 ,  A61M5/145

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves obtaining one or more uncalibrated measurements indicative of the physiological condition, obtaining one or more reference measurements of the physiological condition, determining a raw calibration factor based on a relationship between the one or more uncalibrated measurements and the one or more reference measurements corresponding to the respective uncalibrated measurements of the one or more uncalibrated measurements, and determining an adjusted calibration factor based at least in part on an expected calibration factor and the raw calibration factor, wherein operation of the infusion device to deliver the fluid is influenced by the adjusted calibration factor.