公开(公告)号：US12019039B2

公开(公告)日：2024-06-25

申请号：US16158043

申请日：2018-10-11

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC: G01N27/02 ,  G01N33/487 ,  G01N33/49

CPC classification number: G01N27/026 ,  G01N33/48707 ,  G01N33/49

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20230360799A1

公开(公告)日：2023-11-09

申请号：US18324820

申请日：2023-05-26

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Benyamin Grosman ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Jeffrey Nishida

IPC: A61B5/145 ,  A61B5/1495 ,  G06N3/126 ,  G06N20/00 ,  A61B5/1473 ,  G16H50/20 ,  G16H40/40

CPC classification number: G16H50/20 ,  A61B5/14532 ,  A61B5/14735 ,  A61B5/1495 ,  G06N3/126 ,  G06N20/00 ,  G16H40/40 ,  A61B5/6849

Abstract: A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programing (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.

公开(公告)号：US11445952B2

公开(公告)日：2022-09-20

申请号：US16388794

申请日：2019-04-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1473 ,  A61M5/142 ,  A61M5/172 ,  A61B5/053

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20190246960A1

公开(公告)日：2019-08-15

申请号：US16388794

申请日：2019-04-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/1473 ,  A61M5/142 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61M5/172

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4836 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/7271 ,  A61B2560/0276 ,  A61B2560/029 ,  A61M5/142 ,  A61M5/1723

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10327686B2

公开(公告)日：2019-06-25

申请号：US14980241

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/053

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10258264B2

公开(公告)日：2019-04-16

申请号：US15483404

申请日：2017-04-10

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  C12Q1/00 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N33/49 ,  G01N33/66 ,  G01N27/327 ,  G01N27/416

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US09854998B2

公开(公告)日：2018-01-02

申请号：US14512102

申请日：2014-10-10

Applicant: Medtronic MiniMed, Inc.

Inventor： Ning Yang ,  Rebecca K. Gottlieb ,  Keith Nogueira ,  Xiaolong Li ,  Bradley Liang ,  Brian T. Kannard

IPC: A61B5/00 ,  A61B5/05 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1473 ,  A61M5/172 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/1451 ,  A61B5/14528 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7242 ,  A61B5/7275 ,  A61M5/1723 ,  F04C2270/0421

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

公开(公告)号：US20170181673A1

公开(公告)日：2017-06-29

申请号：US14980241

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20170181672A1

公开(公告)日：2017-06-29

申请号：US14980152

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61M5/172 ,  A61B5/00 ,  A61M5/142 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4836 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/7271 ,  A61B2560/0276 ,  A61B2560/029 ,  A61M5/142 ,  A61M5/1723

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US09649058B2

公开(公告)日：2017-05-16

申请号：US14261011

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.