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37 条记录 (耗时 0.031 秒)

    Targeting agent for tumor site
    31.
    发明授权
    Targeting agent for tumor site 有权
    肿瘤部位靶向剂

    公开(公告)号：US08961929B2

    公开(公告)日：2015-02-24

    申请号：US13520827

    申请日：2011-01-07

    申请人： Kazutaka Ogiwara ,  Makoto Ohno ,  Masayoshi Kojima ,  Masayuki Kawakami ,  Chihaya Kakinuma ,  Tasuku Sasaki ,  Kiyohito Takada

    发明人： Kazutaka Ogiwara ,  Makoto Ohno ,  Masayoshi Kojima ,  Masayuki Kawakami ,  Chihaya Kakinuma ,  Tasuku Sasaki ,  Kiyohito Takada

    IPC分类号： A61K51/08 ,  A61K49/00

    CPC分类号： A61K49/0034 ,  A61K49/0063 ,  A61K49/0084

    摘要： It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X-Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X-Y sequences may be the same or different.

    摘要翻译： 本发明的目的是提供一种靶向剂，其能够通过利用其累积到这种肿瘤部位的作用，将药物递送到肿瘤部位或肿瘤部位的成像。 本发明提供了一种用于肿瘤部位的靶向剂，其包含涂覆有明胶样蛋白质的亲水性聚合物改性载体，其具有由Gly-XY表示的对胶原蛋白特征的序列的重复，并且具有两个或更多个细胞粘附信号序列 在单分子中，其中X和Y各自独立地表示氨基酸，并且多个Gly-XY序列可以相同或不同。

    Method for detecting a hydrophobic region of a target substance
    33.
    发明申请
    Method for detecting a hydrophobic region of a target substance 审中-公开
    用于检测目标物质的疏水区域的方法

    公开(公告)号：US20080274448A1

    公开(公告)日：2008-11-06

    申请号：US11710429

    申请日：2007-02-26

    申请人： Hirohiko Tsuzuki ,  Masayuki Kawakami ,  Masayoshi Yamamoto

    发明人： Hirohiko Tsuzuki ,  Masayuki Kawakami ,  Masayoshi Yamamoto

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/582 ,  G01N33/542 ,  G01N2458/30

    摘要： An object of the present invention is to provides a method for detecting a hydrophobic region of a target substance that is capable of forming a hydrophobic region, such as a protein, which can detect a fluorescent analyte with high sensitivity with the use of a simple detection apparatus. The present invention provides a method for detecting a hydrophobic region of a target substance which comprises steps of allowing a target substance capable of forming a hydrophobic region to come into contact with a chemiluminescent substance, and assaying chemiluminescence.

    摘要翻译： 本发明的目的是提供一种用于检测能够形成疏水性区域的目标物质的疏水性区域的方法，例如蛋白质，其可以通过使用简单检测来检测具有高灵敏度的荧光分析物 仪器。 本发明提供了一种检测目标物质的疏水区域的方法，其包括使能够形成疏水区域的目标物质与化学发光物质接触的步骤，以及测定化学发光的步骤。

    Benzimidazole compounds and drugs containing the same
    35.
    发明授权
    Benzimidazole compounds and drugs containing the same 失效
    苯并咪唑化合物和含有相同的药物

    公开(公告)号：US06815455B1

    公开(公告)日：2004-11-09

    申请号：US10019249

    申请日：2002-06-05

    申请人： Kozo Aoki ,  Kazuhiro Aikawa ,  Masayuki Kawakami ,  Yongzhe Yan

    发明人： Kozo Aoki ,  Kazuhiro Aikawa ,  Masayuki Kawakami ,  Yongzhe Yan

    IPC分类号： A61K31454

    CPC分类号： C07D401/12

    摘要： A benzimidazole compound or a salt thereof which has an inhibitory action of foaming of macrophages and is useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): wherein R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R2 represents a hydrogen atom, an alkyl group, or an acyl group; R3 represents a functional group on the ring; A represents O or CH2 or CH that forms a double bond with an adjacent carbon atom; L represents a C4-C8 alkylene group or an ethyleneoxy linking group represented by (CH2CH2O)nCH2CH2 wherein n represents 1 or 2; X represents O, S or methylene group; and m represents 0 or 1.

    Benzimidazole compounds
    36.
    发明授权
    Benzimidazole compounds 失效
    苯并咪唑化合物

    公开(公告)号：US06787561B1

    公开(公告)日：2004-09-07

    申请号：US10019668

    申请日：2002-06-05

    申请人： Kozo Aoki ,  Kazuhiro Aikawa ,  Masayuki Kawakami ,  Yongzhe Yan

    发明人： Kozo Aoki ,  Kazuhiro Aikawa ,  Masayuki Kawakami ,  Yongzhe Yan

    IPC分类号： A61K314439

    CPC分类号： C07D401/12 ,  C07D235/28 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

    摘要： A benzimidazole compound or a salt thereof which has an inhibitory action of forming of macrophages and is useful as an active ingredient of an orally available medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): wherein, R1 represents one or more functional groups on the benzene ring selected from the group consisting of hydrogen atom, a halogen atom, a lower alkyl group and a lower alkoxy group; R2 represents hydrogen atom, an alkyl group or an acyl group; L represents a C4-C8 alkylene group or an ethyleneoxy linking group represented as (CH2CH2O)nCH2CH2 wherein n represents 1 or 2; X represents O or NH; Y represents S or a single bond; and Q represents a 5- or 6-membered heterocyclic group which may have a functional group on the ring.

    摘要翻译： 具有抑制巨噬细胞形成作用的苯并咪唑化合物或其盐，可用作由式（I）表示的用于预防和/或治疗动脉硬化的口服药物的活性成分：其中， R 1表示选自氢原子，卤素原子，低级烷基和低级烷氧基的苯环上的一个或多个官能团; R 2表示氢原子，烷基或酰基; L表示作为（CH 2 CH 2 O）n CH 2 CH 2表示的C 4 -C 8亚烷基或亚乙氧基连接基，其中n表示1或2; X表示O或NH; Y表示S或单键; Q表示在环上可具有官能团的5或6元杂环基。

    Double-balanced mixer circuit
    37.
    发明授权
    Double-balanced mixer circuit 失效
    双平衡混频器电路

    公开(公告)号：US5760632A

    公开(公告)日：1998-06-02

    申请号：US641237

    申请日：1996-04-30

    申请人： Masayuki Kawakami ,  Yoshiyasu Tsuruoka

    发明人： Masayuki Kawakami ,  Yoshiyasu Tsuruoka

    IPC分类号： H03D7/12 ,  H03D7/14 ,  G06G7/12

    CPC分类号： H03D7/1441 ,  H03D7/1433 ,  H03D7/1458 ,  H03D2200/0047 ,  H03D2200/0084 ,  H03D2200/009 ,  H03D7/125

    摘要： The present invention relates to a double-balanced mixer circuit. The double-balanced mixer circuit consists of a first differential circuit formed of a first transistor and a second transistor connected differentially to each other for receiving a first input signal; and a second differential circuit formed of a third transistor and a fourth transistor connected differentially to each other for receiving a second input signal; either the junction of the drain or collector of the first transistor and the drain or collector of the third transistor or the junction of the drain or collector of the second transistor and the drain or collector of the fourth transistor producing an output signal having frequency information on the sum of the first input signal and the second input signal or the difference between them. The double-balanced mixer circuit is used suitably as a frequency converter which is used at the high-frequency section in a mobile communications equipment such as portable telephones. The object is to handle sufficiently with a reduced voltage of the power source and to facilitate the input operation.

    摘要翻译： 双平衡混频器电路技术领域本发明涉及一种双平衡混频器电路。 双平衡混频器电路包括由第一晶体管和第二晶体管形成的第一差分电路，第一晶体管和第二晶体管彼此差分地连接以接收第一输入信号; 以及由第三晶体管和第四晶体管形成的第二差分电路，所述第三晶体管和第四晶体管彼此差分地连接以接收第二输入信号; 第一晶体管的漏极或集电极与第三晶体管的漏极或集电极或第二晶体管的漏极或集电极的结点与第四晶体管的漏极或集电极之间的结，产生具有频率信息的输出信号 第一输入信号和第二输入信号之和或它们之间的差。 双平衡混频器电路被适当地用作在诸如便携式电话的移动通信设备中在高频部分使用的频率转换器。 目的是充分地处理电源的降低的电压并且便于输入操作。