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公开(公告)号：US20220080115A1
公开(公告)日：2022-03-17
申请号：US16614229
申请日：2018-05-17
Inventor： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer
Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).
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公开(公告)号：US20220001159A1
公开(公告)日：2022-01-06
申请号：US17293968
申请日：2019-05-17
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Daniel Minahan , Alex G. Abramson , Ester Caffarel Salvador , Vance Soares
Abstract: Actuating components and related methods are generally disclosed. Certain embodiments comprise an actuating component associated with a plurality of microneedles (e.g., for administering a therapeutic agent to a subject). In some embodiments, the actuating component may be administered to a subject such that the plurality of microneedles are deployed at a location internal to the subject (e.g., in the gastrointestinal tract). The actuating component may be contained within, in some embodiments, a capsule (e.g., for oral administration to a subject). In some embodiments, the actuating component has a pre-deployment configuration in which the plurality of microneedles have a first orientation and a deployed configuration in which the plurality of microneedles have a second orientation, different than the first orientation.
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公开(公告)号：US11207272B2
公开(公告)日：2021-12-28
申请号：US16614299
申请日：2018-05-17
Inventor： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , David Dellal , Robert S. Langer
IPC: A61K9/48 , A61J3/07 , A61K9/00 , A61B5/145 , A61B10/02 , A61M5/142 , A61M37/00 , A61N1/32 , A61N1/36 , A61M5/20 , A61M5/32 , A61M31/00 , A61K38/28 , A61M5/158 , A61N1/05
Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).
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公开(公告)号：US20210353174A1
公开(公告)日：2021-11-18
申请号：US17318040
申请日：2021-05-12
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US20210154457A1
公开(公告)日：2021-05-27
申请号：US16691514
申请日：2019-11-21
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
Abstract: Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.
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Patent Agency Ranking
公开(公告)号：US20210046011A1
公开(公告)日：2021-02-18
申请号：US16991536
申请日：2020-08-12
Inventor： Carlo Giovanni Traverso , Joshua Korzenik , Robert S. Langer , Christoph Winfried Johannes Steiger
Abstract: Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.
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公开(公告)号：US10849853B2
公开(公告)日：2020-12-01
申请号：US15317628
申请日：2015-06-11
Inventor： Andrew Bellinger , Shiyi Zhang , Carlo Giovanni Traverso , Robert S. Langer , Stacy Mo , Jiaqi Lin , Angela DiCiccio , Dean Liang Glettig , Lowell L. Wood, Jr. , Philip A. Eckhoff
IPC: A61K9/00 , A61K47/58 , A61K9/48 , A61K47/34 , C08G83/00 , C08G18/73 , C08G63/08 , C08G18/42 , A61K47/69 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/32 , C08L33/02 , C08L33/08 , C08L33/14 , A61K47/10 , A61K47/40 , A61K47/42 , A61M31/00
Abstract: Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
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公开(公告)号：US20200147298A1
公开(公告)日：2020-05-14
申请号：US16613766
申请日：2018-05-17
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
Inventor： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).
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公开(公告)号：US20190326970A1
公开(公告)日：2019-10-24
申请号：US16391740
申请日：2019-04-23
Inventor： Yunfei Ma , Zhihong Luo , Christoph Steiger , Carlo Giovanni Traverso , Fadel Adib
Abstract: Multiple antennas of a beamformer may simultaneously transmit wireless signals at different frequencies. The signals may comprise synchronized, identical wireless commands, each at a different carrier frequency. The transmitted signals may constructively and destructively interfere with each other at a receiver antenna, to form a beat signal. When the transmitted signals constructively interfere, the beat signal may cause a voltage in the receiver to exceed a threshold voltage. The threshold voltage may be a minimum voltage at which a device, which is operatively connected to the receiver antenna, is able to perform energy harvesting or wireless communication. The beamformer may operate under blind channel conditions, because the transmitted frequencies may be selected in such a way as to maximize peak power delivered under all possible channel conditions. The beamformer may deliver wireless power to a sensor or actuator that is located deep inside bodily tissue.
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公开(公告)号：US20190160139A1
公开(公告)日：2019-05-30
申请号：US16119135
申请日：2018-08-31
Applicant: Massachusetts Institute of Technology , The General Hospital Corporation , The Brigham and Women's Hospital, Inc.
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Ameya R. Kirtane , Daniel Cahill , Ganesh Shankar
IPC: A61K38/00 , A61K9/00 , A61K9/51 , A61P35/00 , C12Q1/6858 , C12Q1/6886 , C12N9/04 , C12N9/10
Abstract: Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure.
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