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公开(公告)号：US20210361919A1
公开(公告)日：2021-11-25
申请号：US17055905
申请日：2019-05-17
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Robert S. Langer , Carlo Giovanni Traverso , Alex G. Abramson , David Dellal , Christoph Winfried Johannes Steiger , Niclas Roxhed , Ester Caffarel Salvador , Vance Soares , Daniel Minahan , Morten Revsgaard Frederiksen
摘要： Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component h contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.
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公开(公告)号：US20220202721A1
公开(公告)日：2022-06-30
申请号：US17569881
申请日：2022-01-06
发明人： Carlo Giovanni Traverso , Joshua Korzenik , Robert S. Langer , Christoph Winfried Johannes Steiger
摘要： Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.
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公开(公告)号：US20240108241A1
公开(公告)日：2024-04-04
申请号：US18541818
申请日：2023-12-15
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
CPC分类号： A61B5/073 , A61B5/4845 , A61B2562/02 , A61B2562/162 , A61B2562/164
摘要： Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US20210353174A1
公开(公告)日：2021-11-18
申请号：US17318040
申请日：2021-05-12
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
摘要： Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US20210046011A1
公开(公告)日：2021-02-18
申请号：US16991536
申请日：2020-08-12
发明人： Carlo Giovanni Traverso , Joshua Korzenik , Robert S. Langer , Christoph Winfried Johannes Steiger
摘要： Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.
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公开(公告)号：US11850034B2
公开(公告)日：2023-12-26
申请号：US17318040
申请日：2021-05-12
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
CPC分类号： A61B5/073 , A61B5/4845 , A61B2562/02 , A61B2562/162 , A61B2562/164
摘要： Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US20220378363A1
公开(公告)日：2022-12-01
申请号：US17730075
申请日：2022-04-26
申请人： Massachusetts Institute of Technology , Trustees of Boston University , The Brigham and Women's Hospital, Inc.
发明人： Timothy Kuan-Ta Lu , Rabia Tugce Yazicigil Kirby , Carlo Giovanni Traverso , Jenna Ahn , Maria Eugenia Inda , Miguel Jimenez , Qijun Liu , Phillip Nadeau , Christoph Winfried Johannes Steiger , Adam Wentworth
IPC分类号： A61B5/00 , C12Q1/6897 , A61B5/145 , A61B5/1459
摘要： Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 μL of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication. The wireless detection of short-lived, disease-associated molecules may support earlier diagnosis of disease than is currently possible, more accurate tracking of disease progression, and more timely communication between patient and their care team supporting remote personalized care.
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公开(公告)号：US20200164193A1
公开(公告)日：2020-05-28
申请号：US16696233
申请日：2019-11-26
发明人： Michael S. Williams , Jason Siu Wei Li , Jacob Coffey , Christoph Winfried Johannes Steiger , Miguel Jimenez , Robert S. Langer , Ester Caffarel Salvador , Alex Abramson
摘要： A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.
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公开(公告)号：US11318293B2
公开(公告)日：2022-05-03
申请号：US16696233
申请日：2019-11-26
发明人： Michael S. Williams , Jason Siu Wei Li , Jacob Coffey , Christoph Winfried Johannes Steiger , Miguel Jimenez , Robert S. Langer , Ester Caffarel Salvador , Alex Abramson , Carlo Giovanni Traverso
摘要： A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.
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