摘要:
Systems and methods for determining the geographic location of a user based on limited and ambiguous information available from the user's mobile electronic communication device are provided. In an embodiment, a computer-based system estimates a device's physical location based on partial identification information collected from the device such as the local area code and cell identification number, and numerous non-locational attributes. When the system determines that the collected information from the device corresponds to more than one single geographic location the system may use additional techniques of iterative disambiguation and filtering to determine a predicted location. Additional techniques may be used to increase the confidence level of the predicted location.
摘要:
Various methods, systems, and computer program products are disclosed for communicating location-based promotional messages to a mobile communication device. The method may include receiving a request associated with a mobile communication device. In response to the request, the method may include determining a location of the mobile communication device and a potential interest of a user of the mobile communication device. Based on the location of the mobile communication device and the potential interest of the user, the method may include identifying a promotional message from among other promotional messages. Upon identification, the method may include communicating the promotional message to be displayed at the mobile communication device.
摘要:
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for content presentation. In one aspect, a method includes receiving a request for an ad to be presented to a user; for a collection of ads, identifying one or more candidate ads including using image keywords derived from images associated with the user to identify the one or more candidate ads; selecting an ad responsive to the ad request from the candidate ads; and sending the selected ad for presentation to the user.
摘要:
Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要:
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要:
An implantable cardioverter defibrillator (ICD) including a set of leads having electrodes disposed therein. The electrodes may include a weld electrode connected to an internal wire of the lead and the ICD and a tip electrode. The tip electrode may have a set of grooves or cut out regions in its outer surface to provide edge effects for currents applied through the tip electrode. The grooves or cut out regions may form gaps in the surface of the tip electrode exposing a medical compound that is housed within the tip electrode. The medical compound may elute through the gaps.
摘要:
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.
摘要:
Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要:
This specification describes technologies relating to geographically localizing mobile communication devices. In general, one aspect of the subject matter described in this specification can be embodied in a method that includes receiving information corresponding to a location of a wireless landmark in a mobile communication network. The method also includes communicating with the wireless landmark to estimate the location of a first node in the mobile communication network proximate to the wireless landmark. Other embodiments of this aspect include corresponding systems, apparatus, and computer program products.
摘要:
Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.