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公开(公告)号:US20120149109A1
公开(公告)日:2012-06-14
申请号:US13357481
申请日:2012-01-24
申请人: Vickie L. Brown-Driver , Ravi Jain
发明人: Vickie L. Brown-Driver , Ravi Jain
IPC分类号: C12N5/071
CPC分类号: C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10T436/143333
摘要: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.
摘要翻译: 提供化合物,组合物和方法用于调节转甲状腺激素的表达。 组合物包含针对核酸编码转甲状腺素蛋白的寡核苷酸。 提供了使用这些化合物调节转甲状腺素蛋白表达和用于诊断和治疗与转甲状腺素蛋白表达相关的疾病和病症的方法。
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公开(公告)号:US08101743B2
公开(公告)日:2012-01-24
申请号:US12273731
申请日:2008-11-19
申请人: Vickie L. Brown-Driver , Ravi Jain
发明人: Vickie L. Brown-Driver , Ravi Jain
CPC分类号: C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10T436/143333
摘要: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.
摘要翻译: 提供化合物,组合物和方法用于调节转甲状腺激素的表达。 组合物包含针对核酸编码转甲状腺素蛋白的寡核苷酸。 提供了使用这些化合物调节转甲状腺素蛋白表达和用于诊断和治疗与转甲状腺素蛋白表达相关的疾病和病症的方法。
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公开(公告)号:US20090082300A1
公开(公告)日:2009-03-26
申请号:US12273731
申请日:2008-11-19
申请人: Vickie L. Brown-Driver , Ravi Jain
发明人: Vickie L. Brown-Driver , Ravi Jain
IPC分类号: A61K31/713 , C07H21/04 , C12N5/06 , G01N33/50 , C12Q1/68
CPC分类号: C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10T436/143333
摘要: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.
摘要翻译: 提供化合物,组合物和方法用于调节转甲状腺激素的表达。 组合物包含针对核酸编码转甲状腺素蛋白的寡核苷酸。 提供了使用这些化合物调节转甲状腺素蛋白表达和用于诊断和治疗与转甲状腺素蛋白表达相关的疾病和病症的方法。
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公开(公告)号:US06187587B1
公开(公告)日:2001-02-13
申请号:US09517584
申请日:2000-03-02
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcription factor 1. Methods of using these compounds for modulation of E2F transcription factor 1 expression and for treatment of diseases associated with expression of E2F transcription factor 1 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节E2F转录因子1的表达。该组合物包含靶向编码E2F转录因子1的核酸的反义化合物,特别是反义寡核苷酸。使用这些化合物调节E2F转录因子1的方法 提供了表达和治疗与E2F转录因子1表达相关的疾病。
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5.
公开(公告)号:US5514577A
公开(公告)日:1996-05-07
申请号:US31147
申请日:1993-03-12
申请人: Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
发明人: Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
IPC分类号: C12N15/09 , A61K31/70 , A61K31/7088 , A61K38/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07H21/04 , C07K14/03 , C12N15/113 , C12N15/117 , C12Q1/70 , C12N7/06
CPC分类号: C12N15/1133 , A61K31/70 , C07H21/00 , C07K14/005 , C12N15/1137 , C12N15/117 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/346 , C12N2310/3517 , C12N2310/3521 , C12N2710/16622
摘要: Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a herpesvirus gene corresponding to one of the open reading frames UL5, UL8, UL9, UL20, UL27, UL29, UL30, UL42, UL52 and IE175 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site, a coding region or a 5'-untranslated region. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide of the invention are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译: 提供组合物和方法用于治疗和诊断疱疹病毒感染。 根据优选实施方案,提供寡核苷酸,其与衍生自对应于开放阅读框UL5,UL8,UL9,UL20,UL27,UL29,UL20,UL27,UL29,UL30,UL42,UL52和IE175之一的疱疹病毒基因的RNA或DNA特异性杂交 单纯疱疹病毒1型。寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。 在其它优选实施方案中,寡核苷酸与翻译起始位点,编码区或5'-非翻译区具体杂交。 公开了治疗疑似被疱疹病毒感染的动物的方法,包括使动物与本发明的寡核苷酸接触。 公开了用于治疗由单纯疱疹病毒1型,2型单纯疱疹病毒,巨细胞病毒,人疱疹病毒6,爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。
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公开(公告)号:US5952490A
公开(公告)日:1999-09-14
申请号:US403888
申请日:1995-06-12
申请人: Ronnie C. Hanecak , Kevin P. Anderson , C. Frank Bennett , Ming-Yi Chiang , Vickie L. Brown-Driver , David J. Ecker , Timothy A. Vickers , Jacqueline R. Wyatt , Jean Louis Imbach
发明人: Ronnie C. Hanecak , Kevin P. Anderson , C. Frank Bennett , Ming-Yi Chiang , Vickie L. Brown-Driver , David J. Ecker , Timothy A. Vickers , Jacqueline R. Wyatt , Jean Louis Imbach
IPC分类号: C12N15/09 , A01N63/00 , A61K31/70 , A61K38/00 , A61P31/12 , A61P31/16 , A61P35/00 , C07H21/00 , C07H21/04 , C12N15/113 , C12N15/115 , C12N15/117 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号: A61K31/70 , C07H21/00 , C12N15/1133 , C12N15/1137 , C12N15/115 , C12N15/117 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346
摘要: Modified oligonucleotides having a conserved G.sub.4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A.sub.2 or to modulate the telomere length of a chromosome are provided. G.sub.4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnosis and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A.sub.2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to plat a role in the aging process of a cell and in control of malignant cell growth.
摘要翻译: PCT No.PCT / US93 / 09297 Sec。 371日期:1995年6月12日 102(e)日期1995年6月12日PCT 1993年9月29日PCT公布。 公开号WO94 / 08053 日期1994年04月14日提供了具有保守的G4序列和足够数目的侧翼核苷酸的改变的寡核苷酸以显着抑制病毒如HSV-1或磷脂酶A2的活性或调节染色体的端粒长度。 还提供了G4四重态寡核苷酸结构。 还提供了与磷脂酶A2水平升高相关的病毒相关疾病和疾病的预防,诊断和治疗方法。 还提供了调节染色体端粒长度的方法; 相信端粒长度的调节在细胞衰老过程中起到控制恶性细胞生长的作用。
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7.
公开(公告)号:US20110124715A1
公开(公告)日:2011-05-26
申请号:US12849886
申请日:2010-08-04
申请人: Ronnie C. Hanecak , Kevin P. Anderson , C. Frank Bennett , Ming-Yi Chiang , Vickie L. Brown-Driver , David J. Ecker , Timothy Vickers , Jacqueline R. Wyatt
发明人: Ronnie C. Hanecak , Kevin P. Anderson , C. Frank Bennett , Ming-Yi Chiang , Vickie L. Brown-Driver , David J. Ecker , Timothy Vickers , Jacqueline R. Wyatt
IPC分类号: A61K31/7088 , C12N7/00 , A61P31/16 , A61P31/18 , A61P31/22
CPC分类号: A61K31/70 , A61K38/00 , C07H21/00 , C12N15/1133 , C12N15/1137 , C12N15/115 , C12N15/117 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , C12N2310/3521
摘要: Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases are also provided.
摘要翻译: 提供了具有保守的G4序列和足够数目的侧翼核苷酸以显着抑制病毒活性的修饰的寡核苷酸。 还提供了G4四重态寡核苷酸结构。 还提供了用于病毒相关疾病的预防,诊断和治疗方法。
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公开(公告)号:US07067497B2
公开(公告)日:2006-06-27
申请号:US10038335
申请日:2002-01-02
申请人: Ronnie C. Hanecak , Kevin P. Anderson , C. Frank Bennett , Ming-Yi Chiang , Vickie L. Brown-Driver , David J. Ecker , Timothy A. Vickers , Jacqueline R. Wyatt
发明人: Ronnie C. Hanecak , Kevin P. Anderson , C. Frank Bennett , Ming-Yi Chiang , Vickie L. Brown-Driver , David J. Ecker , Timothy A. Vickers , Jacqueline R. Wyatt
IPC分类号: C07H21/04 , A61K31/7115 , A61K31/712 , A61K31/7125
CPC分类号: A61K31/70 , A61K38/00 , C07H21/00 , C12N15/1133 , C12N15/1137 , C12N15/117 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , C12N2310/3521
摘要: Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.
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