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公开(公告)号：US20180071530A1
公开(公告)日：2018-03-15
申请号：US15699873
申请日：2017-09-08
Applicant: MEDTRONIC, INC.
Inventor： Jonathon E. Giftakis , Timothy J. Denison , Paul H. Stypulkowski , Scott R. Stanslaski , Robert S. Raike , Mae Eng , David E. Linde , Thomas Adamski
CPC classification number: A61N1/3614 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/36142 , A61N1/36185 , A61N2001/083
Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
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公开(公告)号：US20170304629A1
公开(公告)日：2017-10-26
申请号：US15646934
申请日：2017-07-11
Applicant: Medtronic, Inc.
CPC classification number: A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
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33.发明授权公开(公告)号：US09259177B2
公开(公告)日：2016-02-16
申请号：US14452312
申请日：2014-08-05
Applicant: Medtronic, Inc.
Inventor： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC: A61B5/024 , A61B5/00 , A61B5/04 , A61N1/372 , G06F19/00 , G06F17/30 , A61B5/0205 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/16 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/021 , A61B5/03 , A61B5/08
CPC classification number: A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
Abstract: Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
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34.发明授权Clustering of recorded patient neurological activity to determine length of a neurological event 有权记录患者神经活动的聚类，以确定神经系统事件的长度公开(公告)号：US09072832B2
公开(公告)日：2015-07-07
申请号：US14262634
申请日：2014-04-25
Applicant: Medtronic, Inc.
Inventor： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC: A61N1/36 , A61M5/172 , A61B5/04 , A61B5/0476 , A61B5/00
CPC classification number: A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
Abstract translation: 装置和方法检测与神经系统疾病的神经系统事件如癫痫发作相关联的检测簇，以及与治疗疗法相关联的更新治疗参数。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。
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公开(公告)号：US12280261B2
公开(公告)日：2025-04-22
申请号：US17645682
申请日：2021-12-22
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Scott R. Stanslaski , William C. Harding , Ryan Gertenbach , Brian L. Bechard , Nathan A. Torgerson
Abstract: An implantable medical device that includes a memory, stimulation circuitry configured to deliver electrical stimulation to a patient, and processing circuitry operably coupled to the memory. The processing circuitry is configured to: control the stimulation circuitry to output electrical stimulation therapy to a patient via a first electrode combination and control the stimulation circuitry to output a notification stimulation via a second electrode combination and interleaved with the electrical stimulation therapy. The notification stimulation may include an intensity above a perception level of the patient, and the second electrode combination may include an electrode disposed at an implant site of the implantable medical device.
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Patent Agency Ranking
公开(公告)号：US11998748B2
公开(公告)日：2024-06-04
申请号：US17364609
申请日：2021-06-30
Applicant: MEDTRONIC, INC.
Inventor： Jonathon E. Giftakis , Timothy J. Denison , Paul H. Stypulkowski , Scott R. Stanslaski , Robert S. Raike , Mae Eng , David E. Linde , Thomas Adamski
CPC classification number: A61N1/3614 , A61N1/36142 , A61N1/0531 , A61N1/0534 , A61N2001/083 , A61N1/36082 , A61N1/36185
Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
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公开(公告)号：US11529518B2
公开(公告)日：2022-12-20
申请号：US16848595
申请日：2020-04-14
Applicant: Medtronic, Inc.
Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
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公开(公告)号：US20220061743A1
公开(公告)日：2022-03-03
申请号：US17459466
申请日：2021-08-27
Applicant: Medtronic, Inc.
Inventor： Eric M. Christensen , Philip E. Tracton , Walton W. Baxter, III , Eric J. Panken , John Wainwright , Randal C. Schulhauser , Jonathon E. Giftakis , Nathalie Virag , Avram Scheiner , Ekaterina Ippolito
Abstract: Devices, systems, and techniques are described for detecting stroke or seizure with a compact system. For example, a system includes a memory, a plurality of electrodes, and sensing circuitry configured to sense, via at least two electrodes of the plurality of electrodes, electrical signals from a patient, and generate, based on the electrical signals, physiological information. The system may also include processing circuitry configured to receive, from the sensing circuitry, the physiological information, determine, based on the physiological information, a seizure metric indicative of a seizure status of the patient and a stroke metric indicative of a stroke status of the patient, and store the seizure metric and the stroke metric in the memory. A housing may carry the plurality of electrodes and contain both of the sensing circuitry and the processing circuitry.
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公开(公告)号：US20200306542A1
公开(公告)日：2020-10-01
申请号：US16848595
申请日：2020-04-14
Applicant: Medtronic, Inc.
Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
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公开(公告)号：US10052485B2
公开(公告)日：2018-08-21
申请号：US14920468
申请日：2015-10-22
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Paul H. Stypulkowski
CPC classification number: A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
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