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公开(公告)号：US11315662B2
公开(公告)日：2022-04-26
申请号：US16594301
申请日：2019-10-07
发明人： Charles M. Clinton , Xinri Cong , Eli N. Glezer , Sudeep Kumar , Carl Stevens , Michael Vock , Jon S. Willoughby
摘要： The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.
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公开(公告)号：US20210402390A1
公开(公告)日：2021-12-30
申请号：US17476880
申请日：2021-09-16
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： B01L3/00 , C12Q1/6876 , G01N33/543 , C12Q1/6816 , C12Q1/6804 , G01N33/68
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US11059046B2
公开(公告)日：2021-07-13
申请号：US16227081
申请日：2018-12-20
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： C12Q1/6804 , G01N33/68 , G01N33/543 , C12Q1/6816 , C12Q1/6876 , B01L3/00
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US20200209234A1
公开(公告)日：2020-07-02
申请号：US16815598
申请日：2020-03-11
发明人： Sudeep Kumar , George Sigal , Michael Tsionsky
IPC分类号： G01N33/543 , C12Q1/6834 , C12Q1/6832 , C12Q1/6823 , G01N33/53
摘要： The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.
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公开(公告)号：US20190201906A1
公开(公告)日：2019-07-04
申请号：US16292521
申请日：2019-03-05
发明人： Eli N. Glezer , Bandele Jeffrey-Coker , Kenneth Page , Sandor Kovacs , Sudeep Kumar , Kristian Roth
IPC分类号： B01L3/00 , F16K11/074
CPC分类号： B01L3/567 , B01L3/502 , B01L3/502738 , B01L3/5085 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , F16K11/0743 , Y10T436/2575
摘要： Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.
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公开(公告)号：US20180029034A1
公开(公告)日：2018-02-01
申请号：US15784399
申请日：2017-10-16
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： B01L3/00 , G01N33/543 , C12Q1/68 , G01N33/68
CPC分类号： B01L3/50853 , B01L2300/021 , B01L2300/043 , B01L2300/0609 , B01L2300/0829 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/54306 , G01N33/54353 , G01N33/6845 , G01N2458/10 , C12Q2563/131
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US20170312751A1
公开(公告)日：2017-11-02
申请号：US15646578
申请日：2017-07-11
发明人： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
CPC分类号： B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
摘要： Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US20170160281A1
公开(公告)日：2017-06-08
申请号：US15440136
申请日：2017-02-23
发明人： Anahit Aghvanyan , Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko , Martin Stengelin
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , A61K39/39533
摘要： The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US20160349253A1
公开(公告)日：2016-12-01
申请号：US15206656
申请日：2016-07-11
发明人： Sudeep Kumar , George Sigal , Michael Tsionsky
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/54386 , C12Q1/6823 , C12Q1/6832 , C12Q1/6834 , G01N33/5306 , G01N2446/00 , G01N2458/30
摘要： The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.
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公开(公告)号：US20140315742A1
公开(公告)日：2014-10-23
申请号：US14348275
申请日：2012-09-28
申请人： MESO SCALE TECHNOLOGIES, LLC , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/566
CPC分类号： G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
摘要翻译： 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。
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