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    Circumferential ablation device assembly
    32.
    发明授权
    Circumferential ablation device assembly 有权

    公开(公告)号：US06383151B1

    公开(公告)日：2002-05-07

    申请号：US09659477

    申请日：2000-09-11

    Applicant: Chris J. Diederich ,  Michael D. Lesh ,  James C. Peacock, III ,  Michael R. Ross

    Inventor： Chris J. Diederich ,  Michael D. Lesh ,  James C. Peacock, III ,  Michael R. Ross

    IPC: A61B100

    CPC classification number: A61B18/1492 ,  A61B18/00 ,  A61B2017/00243 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61M25/1002 ,  A61M2210/125 ,  A61N7/02 ,  A61N7/022

    Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle. A cylindrical ultrasound transducer is provided on an inner member within the balloon and forms the circumferential ablation member by emitting a radial ultrasound signal which is circumferential to the transducer and highly collimated to the transducer's length. The circumferential ultrasound signal sonically couples to the balloon's outer skin to form the circumferential ablation element that is adapted to ablate a circumferential path of tissue engaged to the balloon.

    Systems and methods for ablating body tissue
    34.
    发明授权
    Systems and methods for ablating body tissue 失效
    用于烧伤身体组织的系统和方法

    公开(公告)号：US5921982A

    公开(公告)日：1999-07-13

    申请号：US846739

    申请日：1997-04-30

    Applicant: Michael D. Lesh ,  Stuart D. Edwards

    Inventor： Michael D. Lesh ,  Stuart D. Edwards

    IPC: A61B18/14 ,  A61B17/36

    CPC classification number: A61B18/1492 ,  A61B2017/003 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/00839 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3782 ,  A61N7/02

    Abstract: A medical probe device for contacting tissue within the body a catheter tube having a control end and a probe end. The probe end includes a housing having a port. An element is located within the housing that is movable between a first position confined within the housing and a second position extending through the port outside the housing. The element has a distal tip adapted to penetrate a tissue region during movement between the first and second position. The element comprises an electrode for emitting electromagnetic radio frequency energy into the tissue region, or cannula with an interior lumen for conveying fluid to and from the tissue region, or a sensor for sensing temperature conditions in the tissue region.

    Abstract translation: 一种医疗探针装置，用于使身体内的组织具有具有控制端和探针端的导管。 探针端部包括具有端口的壳体。 元件位于壳体内，其可在限制在壳体内的第一位置和延伸穿过壳体外部的端口的第二位置之间移动。 元件具有适于在第一和第二位置之间移动期间穿透组织区域的远侧末端。 该元件包括用于将电磁射频能量发射到组织区域中的电极，或具有用于向组织区域输送流体的内腔的插管或用于感测组织区域中的温度条件的传感器。

    Systems and methods for analyzing cardiac biopotential morphologies by cross-correlation
    35.
    发明授权
    Systems and methods for analyzing cardiac biopotential morphologies by cross-correlation 失效
    通过互相关分析心脏生物电位形态的系统和方法

    公开(公告)号：US5792064A

    公开(公告)日：1998-08-11

    申请号：US949287

    申请日：1997-10-21

    Applicant: Dorin Panescu ,  Michael D. Lesh ,  David K. Swanson ,  James G. Whayne

    Inventor： Dorin Panescu ,  Michael D. Lesh ,  David K. Swanson ,  James G. Whayne

    IPC: A61B18/14 ,  A61N1/362 ,  A61B5/04

    CPC classification number: A61B18/1492 ,  A61N1/362

    Abstract: An analog or digital processing element and associated method analyses electrograms or electrocardiograms to locate sites potentially appropriate for ablation. The element and method compares a first number of electrogram or electrocardiogram samples recorded over time during a cardiac event of known diagnosis with a second number of paced electrogram or electrocardiogram samples recorded over time. The comparison cross-correlates the first number of electrogram samples with the second number of paced electrogram samples. The element and method generate an output based upon the cross-correlation. The element and method compare the output to a predetermined value to determine whether a pacing site for the paced electrogram or electrocardiogram samples is near to a potential ablation site.

    Abstract translation: 模拟或数字处理元件和相关联的方法分析电描记图或心电图以定位潜在适合消融的位置。 元件和方法将在已知诊断的心脏事件期间随时间记录的第一数量的电描记图或心电图样本与随时间记录的第二数量的起搏电描记图或心电图样品进行比较。 该比较将第一数量的电描记图样本与第二数量的步调电子照相样本相互关联。 元素和方法基于互相关产生输出。 元件和方法将输出与预定值进行比较，以确定起搏电图或心电图样本的起搏部位是否接近潜在的消融部位。

    Coaptation enhancement implant, system, and method
    36.
    发明授权
    Coaptation enhancement implant, system, and method 有权
    接合增强植入物，系统和方法

    公开(公告)号：US08845717B2

    公开(公告)日：2014-09-30

    申请号：US13099532

    申请日：2011-05-03

    Applicant: Alex Khairkhahan ,  Michael D. Lesh

    Inventor： Alex Khairkhahan ,  Michael D. Lesh

    IPC: A61F2/24 ,  A61F2/00 ,  A61B17/068 ,  A61B17/064 ,  A61B17/12 ,  A61B17/04 ,  A61B17/00

    CPC classification number: A61F2/246 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0649 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/0003

    Abstract: Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

    Abstract translation: 植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着 血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空 血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。 在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。 阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。 可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

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