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    Coaptation enhancement implant, system, and method
    1.
    发明授权
    Coaptation enhancement implant, system, and method 有权
    接合增强植入物，系统和方法

    公开(公告)号：US08845717B2

    公开(公告)日：2014-09-30

    申请号：US13099532

    申请日：2011-05-03

    申请人： Alex Khairkhahan ,  Michael D. Lesh

    发明人： Alex Khairkhahan ,  Michael D. Lesh

    IPC分类号： A61F2/24 ,  A61F2/00 ,  A61B17/068 ,  A61B17/064 ,  A61B17/12 ,  A61B17/04 ,  A61B17/00

    CPC分类号： A61F2/246 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0649 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/0003

    摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

    摘要翻译： 植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着 血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空 血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。 在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。 阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。 可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

    COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD
    2.
    发明申请
    COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD 有权
    加工植入，系统和方法

    公开(公告)号：US20120197388A1

    公开(公告)日：2012-08-02

    申请号：US13099532

    申请日：2011-05-03

    申请人： Alex Khairkhahan ,  Michael D. Lesh

    发明人： Alex Khairkhahan ,  Michael D. Lesh

    IPC分类号： A61F2/24

    CPC分类号： A61F2/246 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0649 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/0003

    摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

    摘要翻译： 植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着 血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空 血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。 在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。 阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。 可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

    Apparatus and methods for optimizing anchoring force
    7.
    发明申请
    Apparatus and methods for optimizing anchoring force 有权
    用于优化锚固力的装置和方法

    公开(公告)号：US20050277981A1

    公开(公告)日：2005-12-15

    申请号：US10865243

    申请日：2004-06-09

    申请人： Tracy Maahs ,  Richard Ewers ,  Vahid Saadat ,  Alex Khairkhahan ,  Kenneth Michlitsch

    发明人： Tracy Maahs ,  Richard Ewers ,  Vahid Saadat ,  Alex Khairkhahan ,  Kenneth Michlitsch

    IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/064 ,  A61B17/08 ,  A61B19/00

    CPC分类号： A61B17/0482 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0644 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

    摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

    摘要翻译： 本文描述了用于优化锚固力的装置和方法。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

    Apparatus and methods for optimizing anchoring force
    8.
    发明授权
    Apparatus and methods for optimizing anchoring force 有权
    用于优化锚固力的装置和方法

    公开(公告)号：US08206417B2

    公开(公告)日：2012-06-26

    申请号：US10865243

    申请日：2004-06-09

    申请人： Tracy D. Maahs ,  Richard C. Ewers ,  Vahid Saadat ,  Alex Khairkhahan ,  Kenneth J. Michlitsch

    发明人： Tracy D. Maahs ,  Richard C. Ewers ,  Vahid Saadat ,  Alex Khairkhahan ,  Kenneth J. Michlitsch

    IPC分类号： A61B17/04

    CPC分类号： A61B17/0482 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0644 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

    摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

    摘要翻译： 本文描述了用于优化锚固力的装置和方法。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。