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    COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD
    1.
    发明申请
    COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD 有权
    加工植入，系统和方法

    公开(公告)号：US20120197388A1

    公开(公告)日：2012-08-02

    申请号：US13099532

    申请日：2011-05-03

    申请人： Alex Khairkhahan ,  Michael D. Lesh

    发明人： Alex Khairkhahan ,  Michael D. Lesh

    IPC分类号： A61F2/24

    CPC分类号： A61F2/246 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0649 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/0003

    摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

    摘要翻译： 植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着 血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空 血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。 在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。 阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。 可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

    Coaptation enhancement implant, system, and method
    2.
    发明授权
    Coaptation enhancement implant, system, and method 有权
    接合增强植入物，系统和方法

    公开(公告)号：US08845717B2

    公开(公告)日：2014-09-30

    申请号：US13099532

    申请日：2011-05-03

    申请人： Alex Khairkhahan ,  Michael D. Lesh

    发明人： Alex Khairkhahan ,  Michael D. Lesh

    IPC分类号： A61F2/24 ,  A61F2/00 ,  A61B17/068 ,  A61B17/064 ,  A61B17/12 ,  A61B17/04 ,  A61B17/00

    CPC分类号： A61F2/246 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0649 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/0003

    摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

    摘要翻译： 植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着 血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空 血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。 在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。 阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。 可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

    CIRCUMFERENTIAL ABLATION DEVICE ASSEMBLY
    7.
    发明申请
    CIRCUMFERENTIAL ABLATION DEVICE ASSEMBLY 有权
    循环消除装置组件

    公开(公告)号：US20090221996A1

    公开(公告)日：2009-09-03

    申请号：US12464473

    申请日：2009-05-12

    申请人： Michael D. Lesh

    发明人： Michael D. Lesh

    IPC分类号： A61B18/18 ,  A61B18/14 ,  A61B18/04 ,  A61N7/00

    CPC分类号： A61B18/1492 ,  A61B18/00 ,  A61B18/1815 ,  A61B2017/00243 ,  A61B2017/22038 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00011 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00369 ,  A61B2018/00375 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00994 ,  A61B2218/002 ,  A61N7/02

    摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle.

    摘要翻译： 本发明是适于在肺静脉中形成圆周传导阻滞的周缘消融装置组件。 该组件包括圆周消融元件，其适于沿着围绕肺静脉管腔的肺静脉壁消融组织的周缘区域，从而横切肺静脉的导电性，以抵抗沿着其纵向轴线并进入左心房的传导。 周向消融元件包括可膨胀构件，其具有可从径向收缩位置到径向扩张位置的可调节的工作长度。 赤道带包围工作长度的外表面，并且适于在由消融致动器致动时消融邻近的组织。 赤道带相对于可扩展构件的纵向轴线具有相对于工作长度窄的长度，并且当工作长度处于径向扩张位置时也比其圆周短得多。 绝缘体的图案可以包括在消融元件上，否则将跨越工作长度以形成所描述的赤道带。 可膨胀构件还适于在其口部的区域中符合肺静脉，例如通过提供大量径向顺应性或通过沿具有远端减小外径的工作长度提供锥形。 在组合组件中邻近周缘消融元件提供线性消融元件，该组合组件适用于在左心室的肺静脉口区域中的侵入性较小的“迷宫”型手术。

    IMPLANTABLE PROSTHESIS WITH OPEN CELL FLOW REGULATION
    8.
    发明申请
    IMPLANTABLE PROSTHESIS WITH OPEN CELL FLOW REGULATION 审中-公开
    具有开放细胞流调节的可植入性

    公开(公告)号：US20090198331A1

    公开(公告)日：2009-08-06

    申请号：US12024846

    申请日：2008-02-01

    申请人： Randy J. Kesten ,  Michael D. Lesh

    发明人： Randy J. Kesten ,  Michael D. Lesh

    IPC分类号： A61F2/12

    CPC分类号： A61F2/12

    摘要： An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.

    摘要翻译： 提供具有保持可流动物质的膜的可植入假体。 膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。 孔口具有在将假体植入病人之后可由使用者调节的尺寸。

    BREAST IMPLANT WITH ADJUSTABLE COMPRESSION RESPONSE
    9.
    发明申请
    BREAST IMPLANT WITH ADJUSTABLE COMPRESSION RESPONSE 审中-公开
    乳房植入物可调节压力响应

    公开(公告)号：US20090198328A1

    公开(公告)日：2009-08-06

    申请号：US12024826

    申请日：2008-02-01

    申请人： Randy J. Kesten ,  Michael D. Lesh

    发明人： Randy J. Kesten ,  Michael D. Lesh

    IPC分类号： A61F2/12

    CPC分类号： A61F2/12

    摘要： An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.

    摘要翻译： 提供具有保持可流动物质的膜的可植入假体。 膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。 孔口具有在将假体植入病人之后可由使用者调节的尺寸。