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公开(公告)号：US06447773B1
公开(公告)日：2002-09-10
申请号：US09416874
申请日：1999-10-13
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
IPC分类号： A61K3848
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了clpL多肽和编码clpL多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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公开(公告)号：US06274376B1
公开(公告)日：2001-08-14
申请号：US08923511
申请日：1997-09-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
IPC分类号： C12N1500
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing clpL polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了clpL多肽和编码clpL多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用clpL多肽筛选抗菌化合物的方法。
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公开(公告)号：US06252044B1
公开(公告)日：2001-06-26
申请号：US08977555
申请日：1997-11-25
申请人： Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
发明人： Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
IPC分类号： C07K100
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12Y205/01009 , C12Y207/01002
摘要： The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号：US06248556B1
公开(公告)日：2001-06-19
申请号：US08879098
申请日：1997-06-19
申请人： Michael Terence Black , Martin Karl Russel Burnham , John Edward Hodgson , David Justin Charles Knowles , Richard O Nicholas , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Judith M Ward
发明人： Michael Terence Black , Martin Karl Russel Burnham , John Edward Hodgson , David Justin Charles Knowles , Richard O Nicholas , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Judith M Ward
IPC分类号： C12P2100
CPC分类号： C12N9/78 , A61K39/00 , C07K14/31 , C07K16/1275 , C12Y305/04025
摘要： The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译： 本发明提供了ERA多肽和编码ERA多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用ERA多肽以防止感染，特别是细菌感染的方法。
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公开(公告)号：US06465621B1
公开(公告)日：2002-10-15
申请号：US09631548
申请日：2000-08-03
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： C07K1700
CPC分类号： C12N9/78 , A61K39/00 , C07K14/31 , C07K16/1275 , C12Y305/04025
摘要： The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译： 本发明提供了ERA多肽和编码ERA多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用ERA多肽以防止感染，特别是细菌感染的方法。
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公开(公告)号：US06228619B1
公开(公告)日：2001-05-08
申请号：US08948265
申请日：1997-10-09
申请人： Simon J Foster , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Simon J Foster , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： C12N1509
CPC分类号： C12Y302/01096 , A61K39/00 , A61K2039/53 , C07K14/31 , C07K16/1275 , C12N9/2402 , C12N9/78 , C12Y302/01023 , C12Y305/04025
摘要： The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了氨基葡糖苷酶多肽和编码氨基葡糖苷酶多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。 还提供了利用氨基葡糖苷酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06287803B1
公开(公告)日：2001-09-11
申请号：US08965130
申请日：1997-11-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
IPC分类号： C12N1531
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号：US06248576B1
公开(公告)日：2001-06-19
申请号：US09493459
申请日：2000-01-28
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Riechard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Riechard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N904
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨醇脱氢酶多肽和编码组氨醇脱氢酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用组氨醇脱氢酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06348578B1
公开(公告)日：2002-02-19
申请号：US09417511
申请日：1999-10-14
申请人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
发明人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
IPC分类号： C07K100
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要： The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了适应多肽和编码适应多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用适当多肽筛选抗菌化合物的方法。
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40.发明授权DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae 失效从肺炎链球菌编码腺嘌呤磷酸核糖基转移酶的DNA
公开(公告)号：US06165762A
公开(公告)日：2000-12-26
申请号：US958668
申请日：1997-10-27
申请人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
发明人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12N15/00 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/46 , G01N33/50 , C07H21/04 , C12N1/20
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要： The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了适应多肽和编码适应多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用适当多肽筛选抗菌化合物的方法。
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