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公开(公告)号：US06348578B1
公开(公告)日：2002-02-19
申请号：US09417511
申请日：1999-10-14
申请人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
发明人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
IPC分类号： C07K100
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要： The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了适应多肽和编码适应多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用适当多肽筛选抗菌化合物的方法。
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2.发明授权DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae 失效从肺炎链球菌编码腺嘌呤磷酸核糖基转移酶的DNA
公开(公告)号：US06165762A
公开(公告)日：2000-12-26
申请号：US958668
申请日：1997-10-27
申请人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
发明人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12N15/00 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/46 , G01N33/50 , C07H21/04 , C12N1/20
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要： The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了适应多肽和编码适应多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用适当多肽筛选抗菌化合物的方法。
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公开(公告)号：US6017728A
公开(公告)日：2000-01-25
申请号：US978454
申请日：1997-11-25
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Michael Arthur Lonetto
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Michael Arthur Lonetto
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , C07K14/315 , C07K16/12 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/10 , C12P21/06 , C07H17/00 , C12N9/00 , C12N15/00
CPC分类号： C12N9/1085 , C07K14/3156 , C12Y205/01009 , A61K38/00 , A61K39/00
摘要： The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号：US5932701A
公开(公告)日：1999-08-03
申请号：US978458
申请日：1997-11-25
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/46 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N9/1077 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06284878B1
公开(公告)日：2001-09-04
申请号：US08991023
申请日：1997-12-15
申请人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
发明人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
IPC分类号： C07H2102
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了def1多肽和编码def1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用def1多肽筛选抗菌化合物的方法。
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公开(公告)号：US06171835B2
公开(公告)日：2001-01-09
申请号：US09385288
申请日：1999-08-30
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号： C12N900
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12Y205/01009
摘要： The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号：US07250285B2
公开(公告)日：2007-07-31
申请号：US11403784
申请日：2006-04-13
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
CPC分类号： C12N9/1077 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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公开(公告)号：US6025175A
公开(公告)日：2000-02-15
申请号：US110910
申请日：1998-07-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/12 , C12N9/78 , C12N15/54 , C07K16/00 , C12N15/00 , C12Q1/68
CPC分类号： C12N9/1205 , C07K14/3156 , C12N9/78 , C12Y207/01002 , A61K38/00 , A61K39/00
摘要： The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了葡萄糖激酶多肽和编码葡萄糖激酶多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用葡萄糖激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US6165989A
公开(公告)日：2000-12-26
申请号：US935307
申请日：1997-09-22
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Robert King Stodola , Phillip N Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Robert King Stodola , Phillip N Zarfos
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/09 , A61K39/395 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/00 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/04 , C07K14/315 , C12N1/21 , C12N9/16 , C12N15/00 , C12N15/31 , C12N15/55 , C12P21/02 , C12R1/46 , G01N33/15 , G01N33/566 , C07H21/00 , C12N15/63
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/16
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号：US5858718A
公开(公告)日：1999-01-12
申请号：US889711
申请日：1997-07-08
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J. Holmes
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J. Holmes
IPC分类号： G01N33/50 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/78 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , G01N33/68 , C12P21/06 , C07H21/04 , C12N1/00
CPC分类号： C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/90 , C12Y207/01002 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了pcrA多肽和编码pcrA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用pcrA多肽筛选抗菌化合物的方法。
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