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公开(公告)号：US10449244B2
公开(公告)日：2019-10-22
申请号：US16009811
申请日：2018-06-15
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
IPC分类号： A61K39/12 , A61P31/12 , A61P31/14 , A61K9/14 , A61K9/51 , C07K14/005 , C07K16/10 , C12N7/00 , A61K9/00 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/28 , C07K16/28 , A61K39/00
摘要： Aspects of the disclosure describe compositions that comprise RNA polynucleotides having an open reading frame encoding one or more Zika virus antigens. Methods for preparing and using the compositions are also described.
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公开(公告)号：US20190060438A1
公开(公告)日：2019-02-28
申请号：US15746286
申请日：2016-07-21
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
IPC分类号： A61K39/12
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US20190008948A1
公开(公告)日：2019-01-10
申请号：US16036318
申请日：2018-07-16
申请人： ModernaTX, Inc.
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号：US20180344839A1
公开(公告)日：2018-12-06
申请号：US16009880
申请日：2018-06-15
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu , Sayda Mahgoub Elbashir
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US20180344838A1
公开(公告)日：2018-12-06
申请号：US16009848
申请日：2018-06-15
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
CPC分类号： A61K39/12 , A61K9/0019 , A61K9/14 , A61K9/51 , A61K9/5123 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/28 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/6056 , A61P31/14 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392 , Y02A50/51
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US10022435B2
公开(公告)日：2018-07-17
申请号：US15089050
申请日：2016-04-01
申请人： ModernaTX, Inc.
IPC分类号： A61K39/145 , A61K48/00 , A61K39/12 , A61K39/39 , C12N7/00 , A61K31/7105 , A61K9/00 , A61K39/155 , A61K9/127 , A61K9/51 , A61K39/00
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号：US20180086816A1
公开(公告)日：2018-03-29
申请号：US15591820
申请日：2017-05-10
申请人： ModernaTX, Inc.
IPC分类号： C07K14/76 , C07K14/61 , C07K14/50 , C07K14/535 , C07K14/59 , C07K14/605 , C12N15/67 , C07K14/765 , C07K16/00
CPC分类号： C07K14/76 , A61K48/00 , C07K14/50 , C07K14/535 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/765 , C07K16/00 , C07K2319/00 , C12N15/67
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20180085391A1
公开(公告)日：2018-03-29
申请号：US15502368
申请日：2015-08-07
申请人： ModernaTX, Inc.
发明人： Axel Bouchon , Eric Yi-Chun Huang
CPC分类号： A61K31/7105 , A61K9/0048 , A61K9/0051 , A61K9/1271 , A61K38/00 , A61K47/10 , A61K47/24 , A61K48/005 , A61K48/0066 , A61K48/0075
摘要： The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of ophthalmic disease or conditions.
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公开(公告)号：US20230112857A1
公开(公告)日：2023-04-13
申请号：US17758520
申请日：2021-01-08
申请人： ModernaTX, Inc.
IPC分类号： A61K48/00 , C12N15/88 , C07K14/705 , A61K9/127 , A61P37/06
摘要： The disclosure features lipid nanoparticle (LNP) compositions comprising immune checkpoint inhibitor molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding immune checkpoint inhibitor polypeptides, e.g., PD-L1, PD-L2, B7-H3, B7-H4, CD200 Galectin 9 and CTLA4. The LNP compositions of the present disclosure can reprogram dendritic cells, suppress T cells and/or induce immune tolerance in vivo.
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公开(公告)号：US20220193223A1
公开(公告)日：2022-06-23
申请号：US17683171
申请日：2022-02-28
申请人： ModernaTX, Inc.
IPC分类号： A61K39/145 , A61K48/00 , A61K31/7105 , A61K39/12 , A61K39/39 , A61K9/00 , A61K39/155 , A61K9/127 , A61K9/51 , C12N7/00
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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