公开(公告)号：US5985558A

公开(公告)日：1999-11-16

申请号：US837201

申请日：1997-04-14

申请人： Nicholas M. Dean ,  Robert McKay ,  Loren Miraglia ,  Brenda Baker

发明人： Nicholas M. Dean ,  Robert McKay ,  Loren Miraglia ,  Brenda Baker

IPC分类号： A61K38/00 ,  C12N15/113 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/85 ,  C12P19/34

CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/334 ,  C12N2310/335

摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.

摘要翻译： 提供了通过调节活化蛋白1（AP-1）表达来治疗和诊断易于治疗的组合物和方法。 根据本发明的各种实施方案，提供了与c-fos或c-jun，分别编码c-Fos或c-Jun的基因特异性杂交的寡核苷酸。 在优选的实施方案中，提供了通过调节一种或多种AP-1亚基来调节恶性肿瘤的转移的方法。 该方法可以使用本发明的寡核苷酸或调节AP-1或AP-1介导的转录的任何其它试剂来实现。

公开(公告)号：US5877309A

公开(公告)日：1999-03-02

申请号：US910629

申请日：1997-08-13

申请人： Robert McKay ,  Nicholas M. Dean

发明人： Robert McKay ,  Nicholas M. Dean

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K48/00 ,  A61P35/00 ,  C07H21/00 ,  C12N15/113 ,  C12P19/34 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/85

CPC分类号： C12N15/1137 ,  C07H21/00 ,  C12Q1/6886 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/3515 ,  C12Q2600/158

摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. The invention is thus directed to compositions for modulating, diagnostic methods for detecting, and therapeutic methods for inhibiting, the hyperproliferation of cells and formation, development and maintenance of tumors.

摘要翻译： 提供了通过调节编码JunN末端激酶（JNK蛋白）的基因的表达进行治疗的疾病或病症的治疗和诊断的组合物和方法。 本文提供了与编码JNK1，JNK2和JNK3的核酸以及其它JNK蛋白及其特异性同种型特异性杂交的寡核苷酸。 还提供了通过用这种寡核苷酸调节一种或多种JNK蛋白质的表达来治疗患有治疗性干预的疾病或障碍的动物的方法。 还提供了用于治疗和诊断与一种或多种JNK蛋白异常表达相关的疾病或病症的方法。 因此，本发明涉及用于调节，用于检测和用于抑制细胞过度增殖以及形成，发育和维持肿瘤的方法的治疗方法的组合物。

公开(公告)号：US09096851B2

公开(公告)日：2015-08-04

申请号：US13532254

申请日：2012-06-25

申请人： Nicholas M. Dean ,  J. Gordon Foulkes ,  Niall O'Donnell ,  C. Frank Bennett ,  Susan M. Frier

发明人： Nicholas M. Dean ,  J. Gordon Foulkes ,  Niall O'Donnell ,  C. Frank Bennett ,  Susan M. Frier

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/1136 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2310/3521

摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。

公开(公告)号：US08946172B2

公开(公告)日：2015-02-03

申请号：US12547481

申请日：2009-08-26

申请人： Thomas A. Mustoe ,  Nicholas M. Dean ,  Mark Sisco ,  Zol Kryger ,  C. Frank Bennett

发明人： Thomas A. Mustoe ,  Nicholas M. Dean ,  Mark Sisco ,  Zol Kryger ,  C. Frank Bennett

IPC分类号： A01N43/04 ,  C07H21/04

CPC分类号： C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/31 ,  C12N2310/3525

摘要： This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.

摘要翻译： 本发明提供一种在需要的受试者中减少由真皮伤口愈合引起的高血压瘢痕形成的方法，其包括以有效抑制CTGF表达的量向受试者施用抑制结缔组织生长因子（CTGF）表达的反义寡核苷酸，从而 减少肥厚性瘢痕。

公开(公告)号：US08765703B2

公开(公告)日：2014-07-01

申请号：US12963303

申请日：2010-12-08

申请人： Timothy Vickers ,  Nicholas M. Dean

发明人： Timothy Vickers ,  Nicholas M. Dean

IPC分类号： C12N15/11

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节MyD88的表达。 组合物包含靶向编码MyD88的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MyD88表达和治疗MyD88表达相关疾病的方法。

公开(公告)号：US20130096176A1

公开(公告)日：2013-04-18

申请号：US13493827

申请日：2012-06-11

申请人： Christopher John WRAIGHT ,  George Arthur Werther ,  Nicholas M. Dean ,  Kenneth W. Dobie

发明人： Christopher John WRAIGHT ,  George Arthur Werther ,  Nicholas M. Dean ,  Kenneth W. Dobie

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07H21/00

CPC分类号： C07H21/04 ,  A61K38/00 ,  C07H21/00 ,  C07H21/02 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y10T436/143333 ,  C12N2310/3525

摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.

公开(公告)号：US07759318B1

公开(公告)日：2010-07-20

申请号：US11140437

申请日：2005-05-27

申请人： Ranjan Perera ,  Seongjoon Koo ,  Nicholas M. Dean ,  Eric G. Marcusson

发明人： Ranjan Perera ,  Seongjoon Koo ,  Nicholas M. Dean ,  Eric G. Marcusson

IPC分类号： A61K48/00

CPC分类号： C07K14/70567 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： The present invention provides compounds, compositions, and methods for identification of motifs within regulatory regions of genes involved in adipogenesis and adipocyte differentiation. Compounds and compositions are provided for modulating expression of nuclear receptor/transcription factor-regulated genes. Methods for modulating the function of PPAR-γ as well as PPAR-γ-regulated gene promoters, and methods of using oligomeric compounds for diagnosis and treatment of diseases such as obesity and diabetes are also provided.

摘要翻译： 本发明提供用于鉴定参与脂肪形成和脂肪细胞分化的基因调节区内的基序的化合物，组合物和方法。 提供化合物和组合物用于调节核受体/转录因子调节基因的表达。 还提供了调节PPAR-γ的功能以及PPAR-γ调节的基因启动子的方法，以及使用低聚化合物诊断和治疗诸如肥胖和糖尿病等疾病的方法。

公开(公告)号：US20090286849A1

公开(公告)日：2009-11-19

申请号：US12342025

申请日：2008-12-22

申请人： Christopher John WRAIGHT ,  George Arthur Werther ,  Nicholas M. Dean ,  Kenneth W. Dobie

发明人： Christopher John WRAIGHT ,  George Arthur Werther ,  Nicholas M. Dean ,  Kenneth W. Dobie

IPC分类号： A61K31/711 ,  C07H21/00 ,  C12Q1/68 ,  G01N33/68 ,  A61P17/06

CPC分类号： C07H21/04 ,  A61K38/00 ,  C07H21/00 ,  C07H21/02 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y10T436/143333 ,  C12N2310/3525

摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.

摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，该化合物可用于涉及IGF-1R的任何其它病症，包括炎症状况。

公开(公告)号：US07563885B1

公开(公告)日：2009-07-21

申请号：US11135255

申请日：2005-05-23

申请人： Nicholas M. Dean ,  Ming-Yi Chiang ,  Kenneth W. Dobie

发明人： Nicholas M. Dean ,  Ming-Yi Chiang ,  Kenneth W. Dobie

IPC分类号： C07H21/04

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of Tudor-SN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Tudor-SN. Methods of using these compounds for modulation of Tudor-SN expression and for diagnosis and treatment of diseases and conditions associated with expression of Tudor-SN are provided.

摘要翻译： 提供化合物，组合物和方法用于调节Tudor-SN的表达。 组合物包含靶向编码Tudor-SN的核酸的寡核苷酸。 提供了使用这些化合物调节Tudor-SN表达和诊断和治疗与Tudor-SN表达相关的疾病和病症的方法。

公开(公告)号：US20090111767A1

公开(公告)日：2009-04-30

申请号：US12187362

申请日：2008-08-06

申请人： Christoper J. WRAIGHT ,  George A. Werther ,  Nicholas M. Dean ,  Kenneth J. Dobie

发明人： Christoper J. WRAIGHT ,  George A. Werther ,  Nicholas M. Dean ,  Kenneth J. Dobie

IPC分类号： A61K31/7088 ,  C07H21/00 ,  C12Q1/68 ,  A61P17/06

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/72 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12N2310/3525

摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.

摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。