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31.发明授权Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权用于递送治疗剂的可扩展含氟聚合物装置和制备方法公开(公告)号：US06955661B1
公开(公告)日：2005-10-18
申请号：US09411797
申请日：1999-10-01
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen. The tubular member includes at least one microporous portion having a porosity sufficient for the pressurized fluid to permeate through the wall. Substantially all of the nodes within the microporous portion are oriented such that spaces between the nodes form micro-channels extending from the inner surface-to the outer surface of the wall.
摘要翻译： 公开了一种用于将流体输送到体内的治疗部位的可径向扩张的流体输送装置。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。 流体输送装置包括由壁限定的管状构件，其具有横向于管状构件的纵向轴线并在内表面和外表面之间延伸的厚度。 壁的特征在于通过纤维互连的节点的微结构。 当将加压流体引入内腔时，管状构件可从第一缩径直径构型展开至第二增大直径构型。 管状构件包括具有足以使加压流体渗透通过壁的孔隙的至少一个微孔部分。 基本上微孔部分内的所有节点被定向成使得节点之间的空间形成从壁的内表面延伸到外表面的微通道。
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公开(公告)号：US06423089B1
公开(公告)日：2002-07-23
申请号：US09296349
申请日：1999-04-22
IPC分类号： A61F206
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.
摘要翻译： 血管内假体由具有连续表面并且直径小于预期血管的直径的管状衬垫预制件形成。 将衬垫插入到处理部位，并且其片材经历径向膨胀至适合容器的最终尺寸。 使用导管组件实现插入和原位扩张，其中内部支架例如刚性丝状螺旋编织管或可膨胀气囊将衬垫预制件向外压靠在容器的内壁上。 支架或一个或多个简单的内部卡环将扩张的衬垫固定就位。 膨胀的衬垫是多孔的，或在膨胀期间变得更多孔，并且其孔隙率的一个或多个方面是针对固定化处理材料，分离细胞或允许所选材料的受控渗透的预期治疗目标。
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公开(公告)号：US06287337B1
公开(公告)日：2001-09-11
申请号：US09246312
申请日：1999-02-08
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L27/16 , A61L27/34 , A61L27/507 , C08L27/18
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.
摘要翻译： 公开了适合用作血管移植假体的多孔管及其制造方法。 它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。 本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。 发现PTFE壁具有不同孔隙率的径向区域。
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34.发明授权
公开(公告)号：US5474824A
公开(公告)日：1995-12-12
申请号：US268240
申请日：1994-06-29
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , B29C47/00 , B29C55/00 , B29C69/00 , B29D23/00 , B29K27/12 , B29K105/04 , D02J1/06
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/56 , B01D67/0027 , B01D69/02 , B01D69/12 , B01D71/36 , B29C47/0004 , B29C47/0021 , B29C55/005 , B01D2325/02 , B29C47/0023 , B29C47/0026 , B29C47/0042 , B29C47/0057 , B29C47/062 , B29C47/065 , B29K2027/18 , B29K2105/04 , B29L2023/005 , B29L2023/007 , Y10T428/139 , Y10T428/1397 , Y10T428/24273 , Y10T428/249986 , Y10T428/24999 , Y10T428/249992 , Y10T428/31544
摘要： A process for producing a shaped porous article includes the steps of providing an extrudate of a fluoropolymer material which is capable of being stretched and bilaterally stretching the extrudate along a longitudinal axis. The stretching step is carried out under conditions sufficient to yield an article which is substantially uniformly stretched over a major portion of its length. After stretching, the material has a unique through-pore microstructure characterized by elongate nodes connected by fibrils. The stretched material is sintered while being maintained in its stretched state to produce the shaped porous article. A significant feature of the inventive process is that stretching is carried out by displacing both ends of the extruded material as opposed to known method wherein only one end of an extruded material is stretched, resulting in a microporous fluoropolymer article which are different than conventional fluoropolymer stretching/expansion processes.
摘要翻译： 一种生产成形多孔制品的方法包括以下步骤：提供含氟聚合物材料的挤出物，该挤出物能够沿着纵向轴线被拉伸和双向拉伸挤出物。 拉伸步骤在足以产生在其长度的主要部分上基本上均匀拉伸的制品的条件下进行。 拉伸后，该材料具有独特的通孔微结构，其特征在于由原纤维连接的细长节点。 拉伸的材料在保持拉伸状态下被烧结以产生成形的多孔制品。 本发明方法的一个重要特征是通过使挤出材料的两端位移来进行拉伸，与已知方法相反，其中仅挤出材料的一端被拉伸，得到与常规含氟聚合物拉伸不同的微孔含氟聚合物制品 /扩展过程。
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公开(公告)号：US09801982B2
公开(公告)日：2017-10-31
申请号：US12075223
申请日：2008-03-10
CPC分类号： A61L31/10 , A61F2/0063 , A61F2/06 , A61F2250/0067 , A61L31/145
摘要： A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
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公开(公告)号：US08501229B2
公开(公告)日：2013-08-06
申请号：US13404487
申请日：2012-02-24
申请人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
发明人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
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公开(公告)号：US20110144667A1
公开(公告)日：2011-06-16
申请号：US12877919
申请日：2010-09-08
申请人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
发明人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2220/0075 , A61F2230/0004 , A61F2250/0018 , A61F2310/00389 , A61K31/20 , A61L31/10 , A61L31/14 , A61L31/148
摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.
摘要翻译： 支撑组织生长的疝补片在外科手术安装和固定在患者体内时符合组织壁。 疝补片可以包括基部和定位带。 底座由两层相互贴合，例如通过拼接而在贴片的周边彼此固定。 在两层之间设有一个稳定的垫圈，并且在周向围绕稳定垫圈设置线圈，保持垫片在层之间自由浮动。 基部，定位带和稳定垫圈由不分离植入物层或形成袋状空间的结构形成，并且在植入后促进更均匀和汇合的组织结合或生长。 疝补片可以进一步包括基于脂肪酸的材料如ω-3脂肪酸基材料的可水解生物可吸收的交联涂层。
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公开(公告)号：US20080207756A1
公开(公告)日：2008-08-28
申请号：US11711389
申请日：2007-02-27
CPC分类号： A61K31/20
摘要： Exemplary embodiments of the invention provide a dispersing liquid for coating internal body tissues with a bio-absorbable oil, a method of making the dispersing liquid, methods of using the dispersing liquid and a kit for coating internal body tissues using the dispersing liquid. The dispersing liquid includes a suspension of a bio-absorbable oil suspended in a liquid carrier. The invention results in a uniform thin coating of bio-absorbable oil on internal body tissues.
摘要翻译： 本发明的示例性实施方案提供了用生物可吸收油涂覆内部身体组织的分散液，制备分散液的方法，使用分散液的方法和使用分散液涂覆内部身体组织的试剂盒。 分散液包括悬浮在液体载体中的生物可吸收油的悬浮液。 本发明导致生物吸收油在内部身体组织上的均匀薄涂层。
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公开(公告)号：US6042666A
公开(公告)日：2000-03-28
申请号：US105736
申请日：1998-06-26
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , B32B31/00
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.
摘要翻译： 假体的壁具有通过壁的孔隙调节连通的区域。 假体是单一的，但是可以组合成连续的体，其被聚结，使得多孔微结构在阶段通过壁的厚度尺寸明显变化。 一个实施方案完全由氟聚合物形成，并且具有适于支持组织再生和向内生长的至少一个表面。 调制区域是高水入口压力的层次，可降低脉动式液压传递，或局部改变生物材料通过壁的流体出生分布，并允许更多的自然梯度用于组织再生和壁的外部区域的生长。
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公开(公告)号：US6010529A
公开(公告)日：2000-01-04
申请号：US759877
申请日：1996-12-03
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L31/04 , A61L31/10 , A61F2/105 , A61F2002/072 , A61F2240/001 , Y10S623/901
摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g. polytetrafluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.
摘要翻译： 径向可扩展的支撑体被包围在茧内。 在优选的结构中，支撑件是支架，以及聚合物材料管，例如。 聚四氟乙烯（PTFE）穿过支架主体的内部并在支架上自身转回以形成袖带。 然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。 在一个实施例中，管的端部在折回到支架之前膨胀。 成为成品的外表面的端部因此获得更大程度的孔隙率。 中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。 支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。 空间或孔被内聚合物层和外聚合物层覆盖或桥接。 可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。 这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。 在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。 一根管子被套在后面，另一根管子覆盖着袖口支架。 在该实施例中，管的厚度和孔隙度可能基本上不同。 例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。
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