公开(公告)号：US4323530A

公开(公告)日：1982-04-06

申请号：US119479

申请日：1980-02-07

Applicant: Gunther Voss ,  Peter Gruber

Inventor： Gunther Voss ,  Peter Gruber

IPC: B30B11/08 ,  B30B15/00 ,  B29D7/02

CPC classification number: B30B15/0011

Abstract: A method for spraying compression tools, for example, consisting of upper and lower die and matrix, of machines for the manufacture of molded articles, which comprises applying dissolved, molten or suspended lubricants to the tool surfaces, generally before each compression operation, by means of an intermittently and briefly spraying nozzle system.

Abstract translation: 用于喷射压缩工具的方法，例如由用于制造模制品的机器的上模和下模组成的压模，其包括通常在每次压缩操作之前通过装置将溶解的，熔融的或悬浮的润滑剂施加到工具表面 间歇地和短暂地喷涂喷嘴系统。

公开(公告)号：US4322449A

公开(公告)日：1982-03-30

申请号：US109420

申请日：1980-01-03

Applicant: Gunther Voss ,  Peter Gruber

Inventor： Gunther Voss ,  Peter Gruber

IPC: A61K9/16 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/50 ,  B41J3/407 ,  A61K9/00

CPC classification number: A61K9/2095 ,  A61J3/00 ,  B41J3/4073 ,  A61J2205/20

Abstract: A method for the preparation of pharmaceuticals which comprises using a piezoelectric dosing system to dot liquid, dissolved or suspended active substance onto a pharmaceutical carrier.

Abstract translation: 一种制备药物的方法，其包括使用压电剂量系统将液体，溶解或悬浮的活性物质点滴在药物载体上。

公开(公告)号：US08956647B2

公开(公告)日：2015-02-17

申请号：US13951951

申请日：2013-07-26

Applicant: Norbert Otterbeck ,  Peter Gruber

Inventor： Norbert Otterbeck ,  Peter Gruber

IPC: A61K9/52 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K31/60 ,  A61K9/14 ,  A61K31/606

CPC classification number: A61K9/0053 ,  A61K9/141 ,  A61K9/16 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/501 ,  A61K9/5026 ,  A61K9/5042 ,  A61K31/60 ,  A61K31/606

Abstract: An orally administrable pharmaceutical pellet formulation for the treatment of the intestinal tract is disclosed, which comprises a core and an enteric coating, the core including, as a pharmaceutical active compound, aminosalicylic acid or a pharmaceutically tolerable salt or a derivative thereof.

公开(公告)号：US08889184B2

公开(公告)日：2014-11-18

申请号：US11516573

申请日：2006-09-07

Applicant: Peter Gruber ,  Peter Kraahs

Inventor： Peter Gruber ,  Peter Kraahs

IPC: A61K9/46 ,  A61K9/50

CPC classification number: A61K9/5042

Abstract: The present invention relates to a pharmaceutical composition for direct oral administration which is very easy to swallow especially for young children, comprising at least one pharmaceutically active compound. The pharmaceutical composition is present in the form of one or more particles. The particles comprise a core containing the active ingredient which has been provided with one or more coatings. The pharmaceutical composition is preferably administered in combination with a powder and/or granules which, when applied to the tongue, spontaneously generate additional saliva. With the extra saliva, the coated particles form a soft, smooth, but mechanically stable surface perceived as pleasant in the mouth within seconds so that they may be swallowed easily and practically in the right quantity with the extra saliva formed.

Abstract translation: 本发明涉及用于直接口服给药的药物组合物，其特别是对于包含至少一种药学活性化合物的幼儿尤其容易吞咽。 药物组合物以一种或多种颗粒的形式存在。 颗粒包含含有活性成分的芯，其已经具有一个或多个涂层。 药物组合物优选与粉末和/或颗粒组合施用，当施用于舌头时，其自发产生另外的唾液。 随着额外的唾液，涂覆的颗粒形成柔软，光滑但机械稳定的表面，在几秒钟内被感觉到在口中愉快，使得它们可以容易地并且实际上以形成额外的唾液的数量吞咽。

公开(公告)号：US20070272389A1

公开(公告)日：2007-11-29

申请号：US11396107

申请日：2006-03-31

Applicant: Peter Gruber ,  John Knickerbocker

Inventor： Peter Gruber ,  John Knickerbocker

IPC: B22D11/124 ,  B05D5/12

CPC classification number: H05K3/3457 ,  H01L21/288 ,  H01L24/11 ,  H01L24/12 ,  H01L2224/11009 ,  H01L2224/1147 ,  H01L2224/13099 ,  H01L2224/13111 ,  H01L2224/1319 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/181 ,  H05K2203/0113 ,  H05K2203/0557 ,  H01L2924/00

Abstract: A method and apparatus for the formation of coplanar electrical interconnectors. Solder material is deposited onto a wafer, substrate, or other component of an electrical package using a complaint mold such that the terminal ends of the solder material being deposited, i.e., the ends opposite to those forming an attachment to the wafer, substrate, or other component of an electrical package are coplanar with one another. A complaint mold is used having one or more conduits for receiving solder material and having a compliant side and a planar side. The compliant side of the mold is positioned adjacent to the wafer, substrate, or other component of an electrical package allowing solder material to be deposited onto the surface thereof such that the planar side of the compliant mold provides coplanar interconnectors. An Injection Molded Solder (IMS) head can be used as the means for filling the conduits of the compliant mold of the present invention.

Abstract translation: 用于形成共面电连接器的方法和装置。 使用投诉模具将焊料沉积到电气封装的晶片，基板或其他部件上，使得焊料材料的末端被沉积，即与形成与晶片，基板或附件形成连接的端部相对的端部 电气封装的其他部件彼此共面。 使用投诉模具具有一个或多个用于接收焊料材料并具有柔性侧面和平面侧的导管。 模具的柔性侧被定位成与电气封装的晶片，衬底或其它部件相邻，允许将焊料材料沉积到其表面上，使得柔性模具的平面侧提供共面的互连器件。 可以使用注射成型焊料（IMS）头作为填充本​​发明的柔性模具的导管的装置。

公开(公告)号：US06962717B1

公开(公告)日：2005-11-08

申请号：US09890104

申请日：1999-01-29

Applicant: Gerald Huber ,  Peter Gruber

Inventor： Gerald Huber ,  Peter Gruber

IPC: A61K9/32 ,  A61K9/00 ,  A61K9/02 ,  A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K31/135 ,  A61K31/485 ,  A61K31/606 ,  A61K47/32 ,  A61K47/38 ,  A61P25/04 ,  A61P29/00 ,  A61K9/14 ,  A61K9/22 ,  A61K9/46

CPC classification number: A61K9/2081 ,  A61K9/1635 ,  A61K9/5026 ,  A61K9/5073

Abstract: A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 μm, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.

Abstract translation: 一种用于在胃肠道中缓慢释放活性成分的药物组合物，其包含多种含有不溶于胃和肠液的材料的活性成分颗粒，其中颗粒具有包含活性药物成分和 不溶于胃肠液的聚合物，平均内孔径不超过35μm，即使使用相对少量的聚合物也能有效且不依赖于pH的延迟释放。 另外由于保质期长，特别适用于非球形颗粒。

公开(公告)号：US06675444B2

公开(公告)日：2004-01-13

申请号：US10204210

申请日：2002-08-19

Applicant: Peter Gruber

Inventor： Peter Gruber

IPC: D01G1900

CPC classification number: D01G19/10

Abstract: In a top comb for a combing machine, having at least one row of stamped needles that are arranged in a parallel side-by-side relation and enclosed between two cover plates with a free needle projection (8) being left free, wherein compressed air channels are formed between the cover plates and adjacent pairs of needles are provided, in order to increase the efficiency of the cleaning effect, that the needles (1,1′,1″) incorporate embossings such that the congruent embossings of adjacent needles form an air channel (9,9′,9″), wherein the embossings taper in their widths towards the outlet area (outlet opening 11,11′,11″).

Abstract translation: 在用于精梳机的顶梳中，具有至少一排平行的并列关系排列的冲压针，并封闭在两个盖板之间，其中游离针突起（8）保持自由，其中压缩空气 在盖板和相邻的针之间形成通道，为了提高清洁效果，针（1,1'，1“）包括压纹，使得相邻针的一致的压花形成 空气通道（9,9'，9“），其中所述压花的宽度朝向出口区域（出口开口11,11'，11”）逐渐变细。

公开(公告)号：US06171617B2

公开(公告)日：2001-01-09

申请号：US09125210

申请日：1999-01-06

Applicant: Peter Gruber

Inventor： Peter Gruber

IPC: A61K914

CPC classification number: A61K31/192 ,  A61K9/0007 ,  Y10S514/951

Abstract: In particular, the invention relates to a new, clearly dissolving ibuprofen effervescent formulation and a process for the preparation of this formulation. Ibuprofen or (±)2-(4-isobutylphenyl)-propionic acid has the following structural formula and has been for years a proven, non-steroidal antiphlogistic from the group of phenylpropionic acid derivatives, which shows effectiveness in veterinary experimental inflammation models by inhibiting prostaglandin synthesis.

Abstract translation: 特别地，本发明涉及一种新的，明确溶解的布洛芬泡腾制剂及其制备方法。布洛芬或（±）2-（4-异丁基苯基） - 丙酸具有以下结构式， 经苯基丙酸衍生物组证实非甾体类消炎药，其通过抑制前列腺素合成显示了兽医实验炎症模型的有效性。

公开(公告)号：US6015577A

公开(公告)日：2000-01-18

申请号：US421351

申请日：1995-04-12

Applicant: Wolfgang Eisert ,  Peter Gruber

Inventor： Wolfgang Eisert ,  Peter Gruber

IPC: A61K31/60 ,  A61K9/22 ,  A61K9/24 ,  A61K9/48 ,  A61K9/50 ,  A61K9/58 ,  A61P7/02 ,  A61K9/36 ,  A61K9/62 ,  A61K31/62

CPC classification number: A61K9/5084 ,  A61K31/60 ,  A61K9/209 ,  A61K9/4808 ,  Y10S514/822 ,  Y10S514/824

Abstract: The specification describes a pharmaceutical combination consisting of dipyridamole or mopidamol and acetylsalicylic acid or the physiologically acceptable salts thereof, processes for preparing this pharmaceutical combination and the use thereof for the controlled prevention of clot formation.

Abstract translation: 本说明书描述了由双嘧达莫或莫比达莫和乙酰水杨酸或其生理学上可接受的盐组成的药物组合，制备该药物组合的方法及其用于控制​​预防凝块形成的用途。

公开(公告)号：US5932249A

公开(公告)日：1999-08-03

申请号：US619556

申请日：1996-07-15

Applicant: Peter Gruber ,  Hans Joachim Lach ,  Norbert Otterbeck

Inventor： Peter Gruber ,  Hans Joachim Lach ,  Norbert Otterbeck

IPC: A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K31/58 ,  A61K47/32 ,  A61K9/14

CPC classification number: C12Y304/24 ,  A61K31/58 ,  A61K9/5078

Abstract: Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacquer insoluble in gastric fluids but soluble in intestinal fluids and 3 to 20% of at least one lacquer insoluble in both gastric and intestinal fluids; and d) a second lacquer coating consisting of at least one lacquer insoluble in gastric and intestinal fluids. The invention also relates to a process for producing budesonide pellets with a controlled release pattern.

Abstract translation: PCT No.PCT / EP94 / 02531 Sec。 371日期：1996年7月15日 102（e）日期1996年7月15日PCT提交1994年7月29日PCT公布。 公开号WO95 / 08323 日期1995年3月30日公开是具有控制释放模式的布地奈德颗粒，其包含从内到外的：a）中性颗粒; b）微粉化布地奈德和一种或多种水溶性助剂的活性主层; c）第一漆包衣，其由80-97％的至少一种不溶于胃液但可溶于肠液的漆和3至20％至少一种不溶于胃液和肠液的漆组成; 和d）由至少一种不溶于胃液和肠液的漆组成的第二漆层。 本发明还涉及一种具有控制释放模式的布地奈德颗粒的制备方法。