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    Bromhexine delayed-release pharmaceutical form
    32.
    发明授权
    Bromhexine delayed-release pharmaceutical form 失效
    溴马酸缓释药物形式

    公开(公告)号：US4438091A

    公开(公告)日：1984-03-20

    申请号：US393760

    申请日：1982-06-30

    Applicant: Peter Gruber ,  Jochen Schmid ,  Horst Lechner ,  Eckhart Bauer

    Inventor： Peter Gruber ,  Jochen Schmid ,  Horst Lechner ,  Eckhart Bauer

    IPC: A61K9/22 ,  A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50 ,  A61K9/52 ,  A61K31/135 ,  A61P11/10 ,  A61K9/24

    CPC classification number: A61K9/5026 ,  A61K31/135 ,  A61K9/2027 ,  A61K9/2081 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/5078

    Abstract: This invention relates to vehicles for the administration of bromhexine. More specifically, this invention relates to a composition for the delayed release of bromhexine which comprises (i) spheroid particles or tablets comprised of (a) bromhexine and/or acid addition salts thereof and (b) at least one pharmacologically acceptable acid or acidic substance, the total amount of acid substance from acid addition salts present and the acid or acidic substance being in a ratio of at least 2 mols to 1 mol of bromhexine, and (ii) a coating surrounding said spheroid particles or tablets, said coating being comprised of from about 50 to 100 percent by weight of acid-insoluble lacquers soluble in intestinal juices and from about 0 to 50 percent by weight of lacquers insoluble in gastric and intestinal juices and said coating being present in an amount of from about 2 to 30 percent by weight, based upon the weight of the spheroid particles or tablets.

    Abstract translation: 本发明涉及用于施用溴己定的载体。 更具体地说，本发明涉及一种用于延迟释放溴己烯的组合物，其包括（i）由（a）溴己酮和/或其酸加成盐组成的球状颗粒或片剂，和（b）至少一种药理学上可接受的酸或酸性物质 ，存在酸加成盐的酸性物质的总量和酸或酸性物质的比例为至少2摩尔至1摩尔溴己定的比例，和（ii）围绕所述球状颗粒或片剂的涂层，所述涂层包括 约50至100重量％的可溶于肠液的酸不溶性漆和约0至50重量％不溶于胃肠和肠液的漆，并且所述涂层以约2至30重量％的量存在 ，基于球状颗粒或片剂的重量。

    Method of lubricating compression tools of molding machines
    33.
    发明授权
    Method of lubricating compression tools of molding machines 失效
    润滑成型机压缩工具的方法

    公开(公告)号：US4323530A

    公开(公告)日：1982-04-06

    申请号：US119479

    申请日：1980-02-07

    Applicant: Gunther Voss ,  Peter Gruber

    Inventor： Gunther Voss ,  Peter Gruber

    IPC: B30B11/08 ,  B30B15/00 ,  B29D7/02

    CPC classification number: B30B15/0011

    Abstract: A method for spraying compression tools, for example, consisting of upper and lower die and matrix, of machines for the manufacture of molded articles, which comprises applying dissolved, molten or suspended lubricants to the tool surfaces, generally before each compression operation, by means of an intermittently and briefly spraying nozzle system.

    Abstract translation: 用于喷射压缩工具的方法，例如由用于制造模制品的机器的上模和下模组成的压模，其包括通常在每次压缩操作之前通过装置将溶解的，熔融的或悬浮的润滑剂施加到工具表面 间歇地和短暂地喷涂喷嘴系统。

    Particulate form of a pharmaceutical composition which is easy to swallow
    36.
    发明授权
    Particulate form of a pharmaceutical composition which is easy to swallow 有权
    易于吞咽的药物组合物的颗粒形式

    公开(公告)号：US08889184B2

    公开(公告)日：2014-11-18

    申请号：US11516573

    申请日：2006-09-07

    Applicant: Peter Gruber ,  Peter Kraahs

    Inventor： Peter Gruber ,  Peter Kraahs

    IPC: A61K9/46 ,  A61K9/50

    CPC classification number: A61K9/5042

    Abstract: The present invention relates to a pharmaceutical composition for direct oral administration which is very easy to swallow especially for young children, comprising at least one pharmaceutically active compound. The pharmaceutical composition is present in the form of one or more particles. The particles comprise a core containing the active ingredient which has been provided with one or more coatings. The pharmaceutical composition is preferably administered in combination with a powder and/or granules which, when applied to the tongue, spontaneously generate additional saliva. With the extra saliva, the coated particles form a soft, smooth, but mechanically stable surface perceived as pleasant in the mouth within seconds so that they may be swallowed easily and practically in the right quantity with the extra saliva formed.

    Abstract translation: 本发明涉及用于直接口服给药的药物组合物，其特别是对于包含至少一种药学活性化合物的幼儿尤其容易吞咽。 药物组合物以一种或多种颗粒的形式存在。 颗粒包含含有活性成分的芯，其已经具有一个或多个涂层。 药物组合物优选与粉末和/或颗粒组合施用，当施用于舌头时，其自发产生另外的唾液。 随着额外的唾液，涂覆的颗粒形成柔软，光滑但机械稳定的表面，在几秒钟内被感觉到在口中愉快，使得它们可以容易地并且实际上以形成额外的唾液的数量吞咽。

    Pharmaceutical compositions
    37.
    发明授权
    Pharmaceutical compositions 失效
    药物组合物

    公开(公告)号：US06962717B1

    公开(公告)日：2005-11-08

    申请号：US09890104

    申请日：1999-01-29

    Applicant: Gerald Huber ,  Peter Gruber

    Inventor： Gerald Huber ,  Peter Gruber

    IPC: A61K9/32 ,  A61K9/00 ,  A61K9/02 ,  A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K31/135 ,  A61K31/485 ,  A61K31/606 ,  A61K47/32 ,  A61K47/38 ,  A61P25/04 ,  A61P29/00 ,  A61K9/14 ,  A61K9/22 ,  A61K9/46

    CPC classification number: A61K9/2081 ,  A61K9/1635 ,  A61K9/5026 ,  A61K9/5073

    Abstract: A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 μm, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.

    Abstract translation: 一种用于在胃肠道中缓慢释放活性成分的药物组合物，其包含多种含有不溶于胃和肠液的材料的活性成分颗粒，其中颗粒具有包含活性药物成分和 不溶于胃肠液的聚合物，平均内孔径不超过35μm，即使使用相对少量的聚合物也能有效且不依赖于pH的延迟释放。 另外由于保质期长，特别适用于非球形颗粒。

    Top comb for a combing machine
    38.
    发明授权
    Top comb for a combing machine 失效
    用于精梳机的梳子

    公开(公告)号：US06675444B2

    公开(公告)日：2004-01-13

    申请号：US10204210

    申请日：2002-08-19

    Applicant: Peter Gruber

    Inventor： Peter Gruber

    IPC: D01G1900

    CPC classification number: D01G19/10

    Abstract: In a top comb for a combing machine, having at least one row of stamped needles that are arranged in a parallel side-by-side relation and enclosed between two cover plates with a free needle projection (8) being left free, wherein compressed air channels are formed between the cover plates and adjacent pairs of needles are provided, in order to increase the efficiency of the cleaning effect, that the needles (1,1′,1″) incorporate embossings such that the congruent embossings of adjacent needles form an air channel (9,9′,9″), wherein the embossings taper in their widths towards the outlet area (outlet opening 11,11′,11″).

    Abstract translation: 在用于精梳机的顶梳中，具有至少一排平行的并列关系排列的冲压针，并封闭在两个盖板之间，其中游离针突起（8）保持自由，其中压缩空气 在盖板和相邻的针之间形成通道，为了提高清洁效果，针（1,1'，1“）包括压纹，使得相邻针的一致的压花形成 空气通道（9,9'，9“），其中所述压花的宽度朝向出口区域（出口开口11,11'，11”）逐渐变细。

    Effervescent ibuprofen preparation and process for the production thereof
    39.
    发明授权
    Effervescent ibuprofen preparation and process for the production thereof 失效
    泡腾布洛芬制剂及其制备方法

    公开(公告)号：US06171617B2

    公开(公告)日：2001-01-09

    申请号：US09125210

    申请日：1999-01-06

    Applicant: Peter Gruber

    Inventor： Peter Gruber

    IPC: A61K914

    CPC classification number: A61K31/192 ,  A61K9/0007 ,  Y10S514/951

    Abstract: In particular, the invention relates to a new, clearly dissolving ibuprofen effervescent formulation and a process for the preparation of this formulation. Ibuprofen or (±)2-(4-isobutylphenyl)-propionic acid has the following structural formula and has been for years a proven, non-steroidal antiphlogistic from the group of phenylpropionic acid derivatives, which shows effectiveness in veterinary experimental inflammation models by inhibiting prostaglandin synthesis.

    Abstract translation: 特别地，本发明涉及一种新的，明确溶解的布洛芬泡腾制剂及其制备方法。布洛芬或（±）2-（4-异丁基苯基） - 丙酸具有以下结构式， 经苯基丙酸衍生物组证实非甾体类消炎药，其通过抑制前列腺素合成显示了兽医实验炎症模型的有效性。

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