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1.发明授权
公开(公告)号：US4361546A
公开(公告)日：1982-11-30
申请号：US273643
申请日：1981-06-15
申请人： Herbert Stricker , Bernhard Freund , Heribert Harwalik , Karl L. Rominger , Siegfried Darda , Volkmar Haselbarth , Dietrich Arndts , Wolf D. Bechtel , Gerhard Bozler , Rolf Brickl , Peter Gruber
发明人： Herbert Stricker , Bernhard Freund , Heribert Harwalik , Karl L. Rominger , Siegfried Darda , Volkmar Haselbarth , Dietrich Arndts , Wolf D. Bechtel , Gerhard Bozler , Rolf Brickl , Peter Gruber
CPC分类号： A61K31/55 , A61K9/2853 , A61K9/2866 , A61K9/4808
摘要： A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, were the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.
摘要翻译： 该涂层由水不溶性薄膜形成的药物剂量单位延迟形式具有恒定的pH独立的活性成分释放速率，由包含活性成分的核心和核心上的半渗透扩散涂层组成， 前者，水溶性聚合物和最终掺入其中的酸不溶性聚合物。
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2.发明授权
公开(公告)号：US4578264A
公开(公告)日：1986-03-25
申请号：US604830
申请日：1984-04-27
申请人： Herbert Stricker , Bernhard Freund , Heribert Harwalik , Karl L. Rominger , Siegfried Darda , Volkmar Haselbarth , Dietrich Arndts , Wolf D. Bechtel , Gerhard Bozler , Rolf Brickl , Peter Gruber
发明人： Herbert Stricker , Bernhard Freund , Heribert Harwalik , Karl L. Rominger , Siegfried Darda , Volkmar Haselbarth , Dietrich Arndts , Wolf D. Bechtel , Gerhard Bozler , Rolf Brickl , Peter Gruber
CPC分类号： A61K31/55 , A61K9/2853 , A61K9/2866 , A61K9/4808
摘要： This invention relates to a pharmaceutical dosage unit composition consisting essentially of a gelatin capsule containing (1) a disintegrating core comprising clonidine, said disintegrating core having a readily water-soluble coating, and (2) a plurality of non-disintegrating cores comprising clonidine, said non-disintegrating cores having a coating consisting of from 20 to 90 percent by weight of a water-insoluble film former and from 10 to 80 percent by weight of a water-soluble polymer, the diameter of each of the disintegrating and non-disintegrating cores being at least about 5 mm.
摘要翻译： 本发明涉及一种基本上由明胶胶囊组成的药物剂量单位组合物，其包含（1）包含可乐定的崩解核心，所述崩解核心具有容易水溶性的涂层，和（2）多种非崩解核心，其包含可乐定， 所述非崩解芯具有由20至90重量％的水不溶性成膜剂和10至80重量％的水溶性聚合物组成的涂层，每个分解和不分解的直径 核心至少约5mm。
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3.发明授权
公开(公告)号：US4459279A
公开(公告)日：1984-07-10
申请号：US409131
申请日：1982-08-18
申请人： Herbert Stricker , Bernhard Freund , Heribert Harwalik , Karl L. Rominger , Siegfried Darda , Volkmar Haselbarth , Dietrich Arndts , Wolf D. Bechtel , Gerhard Bozler , Rolf Brickl , Peter Gruber
发明人： Herbert Stricker , Bernhard Freund , Heribert Harwalik , Karl L. Rominger , Siegfried Darda , Volkmar Haselbarth , Dietrich Arndts , Wolf D. Bechtel , Gerhard Bozler , Rolf Brickl , Peter Gruber
CPC分类号： A61K31/55 , A61K9/2853 , A61K9/2866 , A61K9/4808
摘要： A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, where the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.
摘要翻译： 药物剂量单位延迟形式，其具有恒定的pH独立的活性成分释放速率，由包含活性成分的核心和核心上的半渗透扩散涂层组成，其中涂层由水不溶性膜 - 前者，水溶性聚合物和最终掺入其中的酸不溶性聚合物。
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4.发明授权Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof 失效二氯吡咯持续释放形式，包括漆包衣颗粒及其制备
公开(公告)号：US4367217A
公开(公告)日：1983-01-04
申请号：US221834
申请日：1980-12-31
申请人： Peter Gruber , Rolf Brickl , Gerhard Bozler , Herbert Stricker
发明人： Peter Gruber , Rolf Brickl , Gerhard Bozler , Herbert Stricker
IPC分类号： A61K9/16 , A61K9/22 , A61K9/24 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/54 , A61K9/56 , A61K31/505 , A61P9/08 , A61P9/10 , A61K9/26
CPC分类号： A61K9/5042 , A61K31/505 , A61K9/1617 , A61K9/5026 , A61K9/5078
摘要： This invention relates to a composition for the sustained release of dipyridamole which comprises (i) spheroid particles comprised of dipyridamole or crystallized salts thereof and pharmacologically acceptable acid or acid substance, and (ii) a coating surrounding said spheroid particles, said coating being comprised of from about 50 to 100 percent by weight of acid-insoluble lacquers soluble in intestinal juices and from about 0 to 50 percent by weight of lacquers insoluble in gastric and intestinal juices and said coating being present in an amount of from about 3 to 30 percent by weight, based on the weight of the spheroid particles, and to the preparation of such a composition.
摘要翻译： 本发明涉及用于缓释双嘧达莫的组合物，其包括（i）由双嘧达莫或其结晶盐和药理学上可接受的酸或酸性物质组成的球状颗粒，和（ii）围绕所述球状颗粒的涂层，所述涂层由 约50至100重量％的可溶于肠液的酸不溶性漆和约0至50重量％不溶于胃肠和肠液的漆，并且所述涂层以约3至30重量％的量存在， 重量，基于球状颗粒的重量，以及这种组合物的制备。
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公开(公告)号：US4427648A
公开(公告)日：1984-01-24
申请号：US389282
申请日：1982-06-17
申请人： Rolf Brickl , Peter Gruber , Gottfried Schepky , Gerhard Bozler
发明人： Rolf Brickl , Peter Gruber , Gottfried Schepky , Gerhard Bozler
IPC分类号： A61K47/00 , A61K9/16 , A61K9/20 , A61K9/50 , A61K31/505 , A61K47/12 , A61P9/08 , A61P9/10 , A61K9/00 , A61K9/48 , A61K31/445
CPC分类号： A61K9/1617 , A61K31/505 , A61K9/2013 , A61K9/5078
摘要： This invention relates to vehicles for the administration of dipyridamole. More specifically, this invention relates to a method of treating cardiovascular disorders in a host in need of such treatment which comprises administering to said host a cardiovascularly effective amount of a composition comprised of (i) dipyridamole or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 5 acid equivalents to 1 mol of dipyridamole, preferably in the form of particles having particle sizes of from about 0.1 to 2.0 mm.
摘要翻译： 本发明涉及给药双嘧达莫的载体。 更具体地，本发明涉及治疗需要这种治疗的宿主中的心血管疾病的方法，其包括向所述宿主施用心血管有效量的组合物，所述组合物包含（i）双嘧达莫或其酸加成盐，和（ii） 至少一种药理学上可接受的酸或酸物质，存在酸加成盐的酸的总量和酸或酸性物质的比例为至少约5当量酸与1摩尔双嘧达莫的比例，优选为具有颗粒的颗粒形式 尺寸为约0.1至2.0mm。
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公开(公告)号：US4596705A
公开(公告)日：1986-06-24
申请号：US539998
申请日：1983-10-07
IPC分类号： C07D487/04 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50 , A61K9/52 , A61K31/505 , A61K47/12 , A61P7/02 , A61K9/22
CPC分类号： A61K9/2013 , A61K31/505 , A61K9/4841 , A61K9/5078
摘要： This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol.
摘要翻译： 本发明涉及给予莫匹达莫的载体。 更具体地说，本发明涉及在需要这种治疗的宿主中治疗心血管疾病，恶性肿瘤或血栓形成的方法，该方法包括向所述宿主施用心血管，抗重复或抗血栓形成的有效量的组合物，所述组合物包含（i）莫比达莫 或其酸加成盐和（ii）至少一种药理学上可接受的酸或酸物质，存在酸加成盐的酸的总量和酸或酸性物质的比例为至少约1当量酸1摩尔 莫比达莫
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公开(公告)号：US4650664A
公开(公告)日：1987-03-17
申请号：US772166
申请日：1985-09-03
IPC分类号： C07D487/04 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50 , A61K9/52 , A61K31/505 , A61K47/12 , A61P7/02 , A61K9/54
CPC分类号： A61K9/2013 , A61K31/505 , A61K9/4841 , A61K9/5078
摘要： This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol or its acid addition salt.
摘要翻译： 本发明涉及给予莫匹达莫的载体。 更具体地说，本发明涉及在需要这种治疗的宿主中治疗心血管疾病，恶性肿瘤或血栓形成的方法，该方法包括向所述宿主施用心血管，抗重复或抗血栓形成的有效量的组合物，所述组合物包含（i）莫比达莫 或其酸加成盐和（ii）至少一种药理学上可接受的酸或酸物质，存在酸加成盐的酸的总量和酸或酸性物质的比例为至少约1当量酸1摩尔 莫比达莫或其酸加成盐。
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8.发明申请公开(公告)号：US20080317848A2
公开(公告)日：2008-12-25
申请号：US10492270
申请日：2004-04-08
申请人： Thomas Gramatte , Peter Gruber , Michael Heschel , Dirk Pamperin , Jan Ploen , Steffen Scheithauer , Wolfgang Wehner , Peter Guldner
发明人： Thomas Gramatte , Peter Gruber , Michael Heschel , Dirk Pamperin , Jan Ploen , Steffen Scheithauer , Wolfgang Wehner , Peter Guldner
IPC分类号： A61K31/445 , A61K9/20
CPC分类号： A61K9/2009 , A61K9/2054 , A61K9/2846 , A61K9/5026 , A61K9/5078 , A61K31/445
摘要： By suitable retardation oral pharmaceutical compositions containing propiverine or one or several pharmaceutically acceptable salts thereof in an amount of 4 mg to 60 mg propiverine and having a prolonged release of the active agent are produced. Preferably a blend of active agent and optionally one or more acidic substances having a pKa value of less than 6.65 are provided with a retarding coating or are embedded in a matrix which is then optionally coated with further retarding layers.
摘要翻译： 通过合适的阻滞剂，可以制备含有丙哌嗪或其一种或多种药学上可接受的盐的药物组合物，其量为4mg至60mg propiverine并且具有延长的活性剂释放。 优选地，具有pKa值小于6.65的活性剂和任选的一种或多种酸性物质的混合物具有延迟涂层或嵌入基质中，然后任选地涂覆有进一步的阻滞层。
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公开(公告)号：US20070246518A1
公开(公告)日：2007-10-25
申请号：US11409233
申请日：2006-04-21
CPC分类号： B23K3/0638 , B23K1/20 , B23K2101/40 , H01L24/11 , H01L24/742 , H01L2224/13099 , H01L2924/01005 , H01L2924/01006 , H01L2924/01018 , H01L2924/01027 , H01L2924/01033 , H01L2924/01042 , H01L2924/01078 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/181 , H01L2924/00
摘要： A system, method, and apparatus for injection molding conductive bonding material into a plurality of cavities in a surface are disclosed. The method comprises aligning a fill head with a surface. The mold includes a plurality of cavities. The method further includes placing the fill head in substantial contact with the surface. At least a first gas is channeled about a first region of the fill head. The at least first gas has a temperature above a melting point of conductive bonding material residing in a reservoir thereby maintaining the conductive bonding material in a molten state. The conductive bonding material is forced out of the fill head toward the surface. The conductive bonding material is provided into at least one cavity of the plurality of cavities contemporaneous with the at least one cavity being in proximity to the fill head.
摘要翻译： 公开了一种用于将导电接合材料注射成表面中的多个空腔的系统，方法和装置。 该方法包括将填充头与表面对准。 模具包括多个空腔。 该方法还包括将填充头与表面实质接触。 至少第一气体围绕填充头的第一区域引导。 所述至少第一气体具有高于位于储存器中的导电接合材料的熔点的温度，从而将导电接合材料保持在熔融状态。 导电接合材料从表面压出填料头。 导电接合材料被提供到与填充头附近的至少一个空腔同时的多个空腔的至少一个空腔中。
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公开(公告)号：US20070246516A1
公开(公告)日：2007-10-25
申请号：US11409242
申请日：2006-04-21
CPC分类号： B23K3/0638 , B23K1/0016 , B23K3/0623 , B23K2101/40 , H01L24/11 , H01L2224/05568 , H01L2224/05573 , H01L2224/11003 , H01L2224/13099 , H01L2924/01005 , H01L2924/01006 , H01L2924/01027 , H01L2924/01033 , H01L2924/01042 , H01L2924/01078 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/181 , H05K3/3478 , H05K3/3484 , H05K2201/09945 , H05K2203/0113 , H05K2203/043 , H01L2924/00
摘要： A system, method, and device for applying conductive bonding material to a substrate are disclosed. The method includes providing conductive bonding material in a plurality of cavities of a mold. A total number of cavities in the plurality of cavities being greater than a total number of at least one conductive pad of a circuit supporting substrate corresponding to the mold. The conductive bonding material in the mold is heated to a reflow temperature of the conductive bonding material. At least one wettable surface is placed in substantial contact with the heated conductive bonding material in at least one cavity. The mold and the corresponding circuit supporting substrate are brought in close proximity to each other such that the heated conductive bonding material in at least one cavity comes in contact with at least one conductive pad of the corresponding circuit supporting substrate.
摘要翻译： 公开了一种用于将导电接合材料施加到基底的系统，方法和装置。 该方法包括在模具的多个空腔中提供导电接合材料。 多个空腔中的空腔的总数大于对应于模具的电路支撑衬底的至少一个导电焊盘的总数。 将模具中的导电接合材料加热至导电接合材料的回流温度。 在至少一个空腔中至少一个可润湿表面被放置成与被加热的导电接合材料基本接触。 模具和相应的电路支撑衬底彼此靠近，使得至少一个空腔中的加热的导电接合材料与相应的电路支撑衬底的至少一个导电焊盘接触。
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