公开(公告)号：US09273336B2

公开(公告)日：2016-03-01

申请号：US13164990

申请日：2011-06-21

申请人： Ritu Bhalla ,  Qi Chen ,  Qiong Cheng ,  Neeraj Pandey ,  Pierre E. Rouviere ,  Kristin Ruebling-Jass ,  Annapurna Sachan

发明人： Ritu Bhalla ,  Qi Chen ,  Qiong Cheng ,  Neeraj Pandey ,  Pierre E. Rouviere ,  Kristin Ruebling-Jass ,  Annapurna Sachan

IPC分类号： C12P21/06 ,  C12P21/02 ,  C12N1/02 ,  C12N9/10 ,  C12N15/70

CPC分类号： C12P21/02 ,  C12N1/02 ,  C12N9/1025 ,  C12N15/70

摘要： Methods are provided to obtain recombinant microbial cells having at least one genetic modification that increase the buoyant density of a recombinant microbial cell or the buoyant density of inclusion bodies produced within a recombinant microbial cell. Exemplified are genetic modifications that increase the buoyant density of a recombinant microbial cell expressing heterologous peptides and polypeptides. Increasing expression of the genes ysaB, glyQ, glyS or a combination thereof within the recombinant microbial cell produces cells or inclusion bodies having higher buoyant density. A similar effect was achieved by decreasing or disrupting expression of the endogenous gltA gene. Increases in buoyant density render peptide production more efficient with respect to time and costs.

摘要翻译： 提供了获得具有增加重组微生物细胞的浮力密度或在重组微生物细胞内产生的包涵体的浮力密度的至少一种遗传修饰的重组微生物细胞的方法。 示例是增加表达异源肽和多肽的重组微生物细胞的浮力密度的遗传修饰。 在重组微生物细胞内增加基因ysaB，glyQ，glyS或其组合的表达产生具有较高浮力密度的细胞或包涵体。 通过减少或破坏内源性gltA基因的表达也可以获得类似的效果。 浮力密度的增加使肽生产在时间和成本方面更有效率。

公开(公告)号：US08892566B2

公开(公告)日：2014-11-18

申请号：US13073377

申请日：2011-03-28

申请人： Qi Chen ,  Hai Feng Li ,  Guang Zhou Zhang

发明人： Qi Chen ,  Hai Feng Li ,  Guang Zhou Zhang

IPC分类号： G06F17/30

CPC分类号： G06F17/30321

摘要： An index is created for a database by selecting at least one column of a database table as a basis to create the index, generating at least one index of a tree structure according to the at least one column, where a pointer stored in a leaf node of the at least one index is null. In an example embodiment, a value to a pointer is stored in a leaf node according to an intermediate result in response to the intermediate result being generated, where the pointer stored in the leaf node points to a data page storing the intermediate result. The created index can be reused and the intermediate result can be effectively used, such that the efficiency of database operation is improved.

摘要翻译： 通过选择数据库表的至少一列作为创建索引的基础来为数据库创建索引，根据至少一列生成树结构的至少一个索引，其中存储在叶节点中的指针 的至少一个索引为空。 在示例实施例中，响应于生成的中间结果，根据中间结果将指针的值存储在叶节点中，其中存储在叶节点中的指针指向存储中间结果的数据页。 创建的索引可以重用，中间结果可以有效地使用，从而提高数据库操作的效率。

公开(公告)号：US08751051B2

公开(公告)日：2014-06-10

申请号：US13211582

申请日：2011-08-17

申请人： Xiang Yu ,  Xiao-Yong Ma ,  Qi Chen

发明人： Xiang Yu ,  Xiao-Yong Ma ,  Qi Chen

IPC分类号： G05D9/00

CPC分类号： G05D9/12

摘要： A switch control system for controlling an electrically conductive fluid supply to a tank, includes a detection circuit, a gate circuit, a control circuit and a switch circuit. The detection circuit detects a fluid level in the tank and outputs a voltage level signal. The gate circuit receives the voltage level signal and outputs control signals accordingly. The control circuit receives the control signals and outputs a first voltage and a second voltage accordingly. The switch circuit receives the first voltage and the second voltage and turns on and turns off the electrically conductive fluid supply to the tank in accordance with the first voltage and the second voltage.

摘要翻译： 用于控制向罐的导电流体供应的开关控制系统包括检测电路，门电路，控制电路和开关电路。 检测电路检测储罐中的液位并输出电压电平信号。 门电路接收电压电平信号，并相应地输出控制信号。 控制电路接收控制信号并相应地输出第一电压和第二电压。 开关电路接收第一电压和第二电压，并根据第一电压和第二电压接通和断开对槽的导电流体供应。

公开(公告)号：US20120277266A1

公开(公告)日：2012-11-01

申请号：US13548298

申请日：2012-07-13

申请人： Omar D. Lopez ,  Qi Chen ,  Makonen Belema ,  Lawrence G. Hamann

发明人： Omar D. Lopez ,  Qi Chen ,  Makonen Belema ,  Lawrence G. Hamann

IPC分类号： A61K31/4178 ,  C07D403/14 ,  A61K31/422 ,  C07D413/14 ,  A61K31/454 ,  A61P31/14 ,  C07D401/14

CPC分类号： C07D403/14 ,  C07D413/14

摘要： This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

摘要翻译： 本公开涉及如说明书中定义的式（I）新化合物和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。

公开(公告)号：US20120077810A1

公开(公告)日：2012-03-29

申请号：US13262096

申请日：2010-03-29

申请人： Qi Chen ,  Mingxiang Cui ,  Bin Hu ,  Shuangxi Hu ,  Zhifa Pu ,  Philip E. Sanderson ,  Richard Soll ,  Xue Tang ,  Jiabing Wang ,  Yongjin Yan ,  Jinfeng Yao ,  Hongjie Zhang

发明人： Qi Chen ,  Mingxiang Cui ,  Bin Hu ,  Shuangxi Hu ,  Zhifa Pu ,  Philip E. Sanderson ,  Richard Soll ,  Xue Tang ,  Jiabing Wang ,  Yongjin Yan ,  Jinfeng Yao ,  Hongjie Zhang

IPC分类号： A61K31/5377 ,  A61K31/519 ,  A61P35/00 ,  C07D487/04

CPC分类号： A61K31/44 ,  C07D487/04

摘要： The instant invention provides for substituted fused pyrimidine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

摘要翻译： 本发明提供抑制Akt活性的取代的稠合嘧啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

公开(公告)号：US08138215B2

公开(公告)日：2012-03-20

申请号：US12780415

申请日：2010-05-14

申请人： Omar D. Lopez ,  Qi Chen ,  Makonen Belema

发明人： Omar D. Lopez ,  Qi Chen ,  Makonen Belema

IPC分类号： A61K31/4174 ,  C07D233/64

CPC分类号： C07D403/14

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：US20110279938A1

公开(公告)日：2011-11-17

申请号：US13159052

申请日：2011-06-13

申请人： Daniel Shimizu ,  Chi-Shung David Wang ,  Qi Chen

发明人： Daniel Shimizu ,  Chi-Shung David Wang ,  Qi Chen

IPC分类号： H02H3/20 ,  H03L5/00

CPC分类号： H03K19/0013 ,  H03K2217/0018

摘要： Embodiments of a dynamic leakage control circuit for use with graphics processor circuitry are described. The dynamic leakage control circuit selectively enables back biasing of the transistors comprising the graphics processor circuits during particular modes of operation. The back biasing levels are controlled by two separate power rails. A first power rail is coupled to an existing power supply and the second power rail is coupled to a separate adjustable voltage regulator. A separate voltage regulator may also be provided for the first power rail. A hardware-based state machine or software process is programmed to detect the occurrence of one or more modes of operation and adjust the voltage regulators for the first and second power rails to either enable or disable the back biasing state of the circuit, or alter the threshold voltage of the circuit within a specified voltage range.

摘要翻译： 描述了用于图形处理器电路的动态泄漏控制电路的实施例。 动态泄漏控制电路在特定操作模式期间选择性地实现包括图形处理器电路的晶体管的反偏置。 后偏置电平由两个单独的电源轨控制。 第一电力轨耦合到现有电源，第二电力轨耦合到单独的可调电压调节器。 也可以为第一电力轨提供单独的电压调节器。 对基于硬件的状态机或软件过程进行编程以检测一个或多个操作模式的发生，并且调整用于第一和第二电力轨的电​​压调节器以使得或禁用电路的反向偏置状态，或者改变 电路的阈值电压在规定的电压范围内。

公开(公告)号：US08040274B2

公开(公告)日：2011-10-18

申请号：US12308937

申请日：2007-06-14

申请人： Armin Wendler ,  Qi Chen ,  Tamas Bartfai

发明人： Armin Wendler ,  Qi Chen ,  Tamas Bartfai

IPC分类号： G01S13/08

CPC分类号： G01F23/284

摘要： An apparatus for ascertaining and/or monitoring fill level of a medium in a container. The apparatus includes an antenna, which transmits and receives high frequency signals in a predetermined oscillatory mode in a bounded space in a predetermined radiation direction, wherein, in front of the antenna in the radiation direction, an antenna protection element of a material transmissive for the high frequency signals is provided, and wherein a control/evaluation unit is provided, which evaluates the received high frequency signals and ascertains the fill level.

摘要翻译： 一种用于确定和/或监测容器中的介质的填充水平的装置。 该装置包括天线，其以预定的辐射方向在有界空间中以预定的振荡模式发送和接收高频信号，其中在辐射方向上的天线前面，透射天线的材料的天线保护元件 提供高频信号，并且其中提供控制/评估单元，其评估所接收的高频信号并确定填充水平。

公开(公告)号：US20110138396A1

公开(公告)日：2011-06-09

申请号：US12955280

申请日：2010-11-29

申请人： Qi Chen ,  Jun He ,  Guang Lei Li ,  Huo Ding Li ,  Wei Liu

发明人： Qi Chen ,  Jun He ,  Guang Lei Li ,  Huo Ding Li ,  Wei Liu

IPC分类号： G06F9/46

CPC分类号： G06F9/5066

摘要： The present invention discloses a method and system for data distribution in a High-Performance Computing cluster, the High-Performance Computing cluster comprising a Management node and M computation nodes where M is an integer greater than or equal to 2, the Management node distributing the specified data to the M computation nodes, the method comprising steps of: dividing the M computation nodes into m layers where m is an integer greater than or equal to 2; dividing the specified data into k shares where k is an integer greater than or equal to 2; distributing, by the Management node, the k shares of data to a first layer of computation nodes as sub-nodes thereof, each of the first layer of computation nodes obtaining at least one share of data therein; distributing, by each of the computation nodes, the at least one share of data distributed by a parent node thereof to sub-computation nodes thereof; and requesting, by each of the computation nodes, the remaining specified data to other computation nodes, to thereby obtain all the specified data. The method and system enable data to be distributed rapidly to various computation nodes in the High-Performance Computing cluster.

摘要翻译： 本发明公开了一种高性能计算集群中数据分发的方法和系统，该高性能计算集群包括管理节点和M个计算节点，其中M为大于或等于2的整数，管理节点分发 指定的数据到M个计算节点，该方法包括以下步骤：将M个计算节点划分为m个层，其中m是大于或等于2的整数; 将指定的数据划分为k个共享，其中k是大于或等于2的整数; 由管理节点将k份数据分配给第一层计算节点作为其子节点，第一层计算节点中的每一个在其中获得至少一份数据; 由每个计算节点将由其父节点分发的数据的至少一个共享分配给其子计算节点; 并且通过每个计算节点向其他计算节点请求剩余的指定数据，从而获得所有指定的数据。 该方法和系统将数据快速分发到高性能计算集群中的各种计算节点。

公开(公告)号：US20090144607A1

公开(公告)日：2009-06-04

申请号：US12281770

申请日：2007-02-01

申请人： Qi Chen

发明人： Qi Chen

IPC分类号： G06F17/00

CPC分类号： G06F17/245 ,  G06F17/30905

摘要： The present invention discloses a method for localized scrolling table display in a webpage. The method includes: dividing a table being displayed into at least a 2×2 array of an upper left table, a lower left table, an upper right table and a lower right table; setting the lower left table and the upper right table to hide portions that are beyond display area; and setting the lower right table to hide portions that are beyond the display area and to include a vertical scrollbar and a horizontal scrollbar. The upper right table and the lower right table are controlled by the horizontal scrollbar, and the lower left table and the lower right table are controlled by the vertical scrollbar. The present invention is able to display a table in a webpage with a localized scrolling display and a partial frozen display, and allows unlimited number of data columns and rows in the webpage and still maintains good readability. This satisfies the need for displaying table of a large amount of data for data comparison, and allows the user to conveniently and freely scroll any cell of the table to the display area to be displayed.

摘要翻译： 本发明公开了一种网页中的局部滚动表显示方法。 该方法包括：将正在显示的表格划分为左上表，左下表，右上表和右下表的至少2×2数组; 设置左下表和右上表隐藏超出显示区域的部分; 并设置右下表隐藏超出显示区域的部分，并包括垂直滚动条和水平滚动条。 右上表和右下表由水平滚动条控制，左下表和右下表由垂直滚动条控制。 本发明能够在具有本地化滚动显示和部分冷冻显示的网页中显示表格，并且允许网页中的数据列和行数不受限制，并且仍然保持良好的可读性。 这样就满足了显示用于数据比较的大量数据的表格的需要，并且允许用户方便地自由地将表格的任何单元滚动到要显示的显示区域。