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    Implantable barrier device
    34.
    发明申请
    Implantable barrier device 有权
    植入式屏障装置

    公开(公告)号：US20080206305A1

    公开(公告)日：2008-08-28

    申请号：US12075223

    申请日：2008-03-10

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61F2/00 ,  A61K47/12

    CPC分类号： A61L31/10 ,  A61F2/0063 ,  A61F2/06 ,  A61F2250/0067 ,  A61L31/145

    摘要： A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 屏障装置由能够表现出抗炎性质，非炎症性质和/或粘合限制性能的屏障组分形成，并且对损伤的组织产生调节的愈合作用。 阻隔组分可以是至少部分由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 阻挡装置可以具有锚定位置以在阻挡装置上提供与锚定机构相接合的区域。 锚固位置可以包括开口和/或锚定元件。 阻挡装置还可以包括为屏障部件提供附加强度的桁架结构。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Tissue separating device with reinforced support for anchoring mechanisms
    35.
    发明授权
    Tissue separating device with reinforced support for anchoring mechanisms 有权
    组织分离装置，具有用于锚固机构的加强支撑

    公开(公告)号：US09592324B2

    公开(公告)日：2017-03-14

    申请号：US11980155

    申请日：2007-10-30

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61L31/14 ,  A61L31/08

    CPC分类号： A61L31/14 ,  A61F2/0063 ,  A61L31/08

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Barrier layer with underlying medical device and one or more reinforcing support structures
    36.
    发明授权
    Barrier layer with underlying medical device and one or more reinforcing support structures 有权
    具有底层医疗装置和一个或多个加强支撑结构的阻隔层

    公开(公告)号：US09492596B2

    公开(公告)日：2016-11-15

    申请号：US11701799

    申请日：2007-02-02

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61F2/02 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/145 ,  A61F2/0063 ,  A61F2/82 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/606

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Vascular graft
    40.
    发明申请
    Vascular graft 审中-公开
    血管移植

    公开(公告)号：US20050004664A1

    公开(公告)日：2005-01-06

    申请号：US10833930

    申请日：2004-04-27

    申请人： Paul Martakos ,  Joseph Ferraro ,  Theodore Karwoski ,  Ibrahim Dagher

    发明人： Paul Martakos ,  Joseph Ferraro ,  Theodore Karwoski ,  Ibrahim Dagher

    IPC分类号： A61F2/06 ,  A61L27/16

    CPC分类号： A61F2/06 ,  A61F2002/065 ,  A61L27/16 ,  C08L27/18

    摘要： Disclosed are vascular grafts including an expanded copolymer of tetrafluoroethylene (TFE) and perfluoropropylene vinyl ether (PPVE). In certain embodiments, the copolymer includes between about 0.01% and about 1.5% PPVE. Vascular grafts exhibit superior performance properties, e.g., radial strength, and suture strength, and manufacturing properties, e.g., sinter time. Methods of forming vascular grafts from the copolymer also are described.

    摘要翻译： 公开了包括四氟乙烯（TFE）和全氟丙烯乙烯基醚（PPVE）的发泡共聚物的血管移植物。 在某些实施方案中，共聚物包括约0.01％至约1.5％的PPVE。 血管移植物表现出优异的性能，例如径向强度和缝合强度，以及制造性质，例如烧结时间。 还描述了从共聚物形成血管移植物的方法。