公开(公告)号：US11440883B2

公开(公告)日：2022-09-13

申请号：US16811426

申请日：2020-03-06

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuichi Kajita ,  Yuhei Miyanohana ,  Tatsuki Koike ,  Kohei Takeuchi ,  Yoshiteru Ito ,  Norihito Tokunaga ,  Takahiro Sugimoto ,  Tohru Miyazaki ,  Tsuneo Oda ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Keisuke Imamura

IPC: C07D211/56 ,  C07D211/36 ,  C07D405/06 ,  A61P25/26 ,  C07D409/10 ,  A61P25/00 ,  C07D205/04 ,  C07D207/14 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D405/10 ,  C07D405/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11319286B2

公开(公告)日：2022-05-03

申请号：US16635408

申请日：2018-08-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko Fujimoto ,  Kentaro Rikimaru ,  Koichiro Fukuda ,  Hiromichi Sugimoto ,  Takahiro Matsumoto ,  Yuichi Kajita ,  Satoshi Mikami ,  Yuhei Miyanohana ,  Tatsuki Koike ,  Masaki Daini ,  Masaki Ogino ,  Kohei Takeuchi ,  Tohru Miyazaki ,  Yoshiteru Ito ,  Norihito Tokunaga ,  Takahiro Sugimoto ,  Tsuneo Oda ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Keisuke Imamura

IPC: C07D207/14 ,  C07D401/14 ,  C07D403/06 ,  A61P25/28

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11034700B2

公开(公告)日：2021-06-15

申请号：US16491794

申请日：2018-03-07

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi Mikami ,  Masaki Daini ,  Yuhei Miyanohana ,  Hideo Suzuki ,  Kenichiro Shimokawa ,  Yuichi Kajita ,  Masaki Ogino ,  Tatsuki Koike ,  Kohei Takeuchi

IPC: A61K31/40 ,  C07D491/107 ,  C07D207/12 ,  C07D207/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12

Abstract: The present invention provides a substituted pyrrolidine compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US10717748B2

公开(公告)日：2020-07-21

申请号：US16779797

申请日：2020-02-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10273245B2

公开(公告)日：2019-04-30

申请号：US16194540

申请日：2018-11-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D498/08 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D401/14 ,  C07D413/10 ,  C07D417/14 ,  C07D401/10

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09643957B2

公开(公告)日：2017-05-09

申请号：US14650429

申请日：2013-12-10

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Yuichi Kajita ,  Masato Yoshikawa ,  Shuhei Ikeda ,  Hiromi Fukuda

IPC: C07D403/12 ,  C07D471/08 ,  C07D491/08 ,  C07D213/12 ,  C07D498/08 ,  C07D405/12 ,  C07D401/14 ,  C07D417/14 ,  C07D451/04 ,  C07D487/10 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D401/12 ,  C07D239/42 ,  C07D413/04 ,  C07D417/04 ,  C07D451/02 ,  C07D487/18 ,  C07D491/18 ,  C07D403/04 ,  C07D403/14 ,  C07D471/10 ,  A61K9/20 ,  A61K9/48 ,  C07D213/72 ,  C07D487/08 ,  C12N9/99

CPC classification number: C07D498/08 ,  A61K9/2018 ,  A61K9/4858 ,  C07D213/12 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/02 ,  C07D451/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C12N9/99

Abstract: An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09598398B2

公开(公告)日：2017-03-21

申请号：US14781963

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby ,  Shuhei Ikeda ,  Yuichi Kajita ,  Toshiya Nishi

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/497 ,  A61K31/4545 ,  A61K31/444 ,  C07D401/10 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D239/26 ,  C07D417/14 ,  C07D213/34 ,  C07D213/56 ,  C07D213/42

CPC classification number: C07D401/10 ,  C07D213/34 ,  C07D213/42 ,  C07D213/56 ,  C07D239/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20150266872A1

公开(公告)日：2015-09-24

申请号：US14435899

申请日：2013-10-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Tomoaki Hasui ,  Haruhi Ando ,  Hiromi Fukuda ,  Toshiya Nishi

IPC: C07D471/04 ,  C07D519/00 ,  C07D413/04

CPC classification number: C07D471/04 ,  C07D413/04 ,  C07D519/00

Abstract: The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract translation: 本发明提供可用于预防或治疗神经变性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

公开(公告)号：US08895591B2

公开(公告)日：2014-11-25

申请号：US14017819

申请日：2013-09-04

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Osamu Uchikawa ,  Tatsuki Koike ,  Yasutaka Hoashi ,  Takafumi Takai

IPC: C07D263/52 ,  C07D277/60 ,  A61K31/428 ,  A61K31/423 ,  C07D277/62 ,  C07D413/06

CPC classification number: A61K31/428 ,  A61K31/423 ,  C07D263/52 ,  C07D277/60 ,  C07D277/62 ,  C07D413/06

Abstract: The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

Abstract translation: 本发明提供下式表示的化合物，其可用作预防或治疗与褪黑激素或其盐等有关的疾病的药剂。