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54 条记录 (耗时 0.026 秒)

    Method for detecting infectious agents using computer controlled automated image analysis
    33.
    发明申请
    Method for detecting infectious agents using computer controlled automated image analysis 审中-公开
    使用计算机控制的自动图像分析检测感染因子的方法

    公开(公告)号：US20060239533A1

    公开(公告)日：2006-10-26

    申请号：US10543270

    申请日：2002-06-04

    申请人： Triantafyllos Tafas ,  Michael Kilpatrick ,  Petros Tsipouras

    发明人： Triantafyllos Tafas ,  Michael Kilpatrick ,  Petros Tsipouras

    IPC分类号： G06M11/02 ,  G01N33/48 ,  G06K9/00

    CPC分类号： G06K9/00147 ,  C12Q1/04 ,  G01N15/1475 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/30024

    摘要： Computer controlled methods, systems and apparatus for detecting an infectious agent in a host cell, an animal cell, or plant cell, a body fluid or tissue sample to provide information useful to diagnose a disease or prognosticate disease susceptibility, extent or outcome are provided. In one illustrative embodiment, the infected animal cell is a Chlamydia infected mononuclear phagocyte in a blood sample. In another illustrative embodiment, the infected body fluid is a blood sample infected with “fee floating” Chlamydia. Detection and preferably, quantification of such an infected mononuclear phagocyte(s) or blood sample provides information useful in diagnosing or prognosticating susceptibility, extent or outcome of patients suspected of suffering from vascular, coronary or central nervous disease(s) or disorder(s).

    摘要翻译： 提供了用于检测宿主细胞，动物细胞或植物细胞，体液或组织样本中的感染剂的计算机控制方法，系统和装置，以提供用于诊断疾病或预测疾病易感性，程度或结果的信息。 在一个说明性实施方案中，感染的动物细胞是血液样品中衣原体感染的单核吞噬细胞。 在另一说明性实施例中，感染的体液是感染“费用漂浮”衣原体的血液样本。 检测并优选地定量这种受感染的单核吞噬细胞或血液样品提供了可用于诊断或预测怀疑患有血管，冠状动脉或中枢神经疾病或病症的患者的易感性，程度或结果的信息， 。

    DEVICE AND METHOD FOR DETECTING AND LOCALIZING CELLS BY MEANS OF PHOTOSENSITIVE WAVEGUIDES
    35.
    发明申请
    DEVICE AND METHOD FOR DETECTING AND LOCALIZING CELLS BY MEANS OF PHOTOSENSITIVE WAVEGUIDES 失效
    通过感光波形检测和定位细胞的装置和方法

    公开(公告)号：US20080131064A1

    公开(公告)日：2008-06-05

    申请号：US11691989

    申请日：2007-03-27

    申请人： Petros Tsipouras ,  Triantafyllos Tafas

    发明人： Petros Tsipouras ,  Triantafyllos Tafas

    IPC分类号： G02B6/02

    CPC分类号： G02B1/045 ,  G01N21/7703 ,  G01N2021/1725 ,  G01N2021/7783 ,  G02B6/02033 ,  G02B6/1221

    摘要： The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

    摘要翻译： 本发明提供用于在使用光敏波导的样品中检测诸如生物细胞的颗粒的装置和方法。 响应于控制从颗粒发射的辐射，光敏波导以可检测的方式改变其透射率。 在优选实施例中，波导是二维的，并且颗粒的位置以及它们的存在是通过在两个非平行方向扫描波导而获得的。 所提供的装置优选用于定位标记的细胞。 本发明还包括使用所提供的设备来检测和定位单元的控制系统和方法。

    Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
    39.
    发明授权
    Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 失效
    计算机控制稀有细胞的方法和装置，包括胎儿细胞，基于诊断

    公开(公告)号：US07945391B2

    公开(公告)日：2011-05-17

    申请号：US11273229

    申请日：2005-11-14

    申请人： Petros Tsipouras ,  Triantafyllos Tafas

    发明人： Petros Tsipouras ,  Triantafyllos Tafas

    IPC分类号： G06F19/00 ,  G06K9/00 ,  G06K9/20 ,  G06K9/78

    CPC分类号： G06K9/00127 ,  B01J2219/00693 ,  B01J2219/00702 ,  C12Q1/6806 ,  G01N1/2813 ,  G01N1/312 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5005 ,  G01N35/1002 ,  G01N35/1011 ,  G01N2015/1006 ,  G01N2035/1034 ,  G06K9/0014 ,  G06T7/0012 ,  G06T2207/30024

    摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

    摘要翻译： 提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号， 处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。 在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。 第二信号可以通过原位PCR或PCR原位杂交产生。 在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。 在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。