公开(公告)号：US09101339B2

公开(公告)日：2015-08-11

申请号：US12549779

申请日：2009-08-28

申请人： Kazuhiko Takahashi ,  Toshio Nakamura

发明人： Kazuhiko Takahashi ,  Toshio Nakamura

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B17/00 ,  A61B19/00 ,  A61B1/018 ,  A61B17/29 ,  A61B18/14

CPC分类号： A61B17/00234 ,  A61B1/00133 ,  A61B1/018 ,  A61B17/29 ,  A61B18/1492 ,  A61B34/70 ,  A61B34/72 ,  A61B34/74 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2090/0811

摘要： An endoscope apparatus includes an accessory including an actuation portion configured to be actuated, an operating unit for operating the actuation portion, an endoscope including an accessory insertion pass wherein the accessory is adapted to be inserted through the accessory insertion pass from a proximal end portion of the accessory insertion pass to a distal end portion of the accessory insertion pass, and projected from and retracted into the distal end portion of the accessory insertion pass, a detecting unit configured to detect a condition of a part of the accessory, which is projected from the distal end portion of the accessory insertion pass, and a control unit configured to control an actuation of the actuation portion by an operation to the operating detecting unit.

摘要翻译： 一种内窥镜装置，包括：附件，包括构造成被致动的致动部分，用于操作致动部分的操作单元，包括附件插入通道的内窥镜，其中所述附件适于通过所述附件插入通道从所述附件插入通道的近端部分 所述附件插入通过所述附件插入路径的前端部，并且从所述附件插入路径的前端部突出并缩回到所述附件插入路径的前端部，所述检测单元被配置为检测所述附件的一部分的状态， 附件插入通道的远端部分，以及控制单元，其被配置为通过对操作检测单元的操作来控制致动部分的致动。

公开(公告)号：US08449187B2

公开(公告)日：2013-05-28

申请号：US12681248

申请日：2008-07-23

申请人： Toshio Nakamura ,  Tsuneo Nakamura

发明人： Toshio Nakamura ,  Tsuneo Nakamura

IPC分类号： B65D33/02 ,  B65D30/00

CPC分类号： B65D33/02 ,  B65D33/14 ,  B65D75/5883

摘要： A fluid containing bag according to the invention includes a bag main body which is constituted by front and rear two sheets and an entire periphery of which is hermetically sealed except one portion, an inlet/outlet spout one end side of which is connected to the one portion and other end side of which is extended to outside of the bag main body, means for closing an inlet/outlet port of the inlet/outlet spout, and a reinforcing tape attached to a portion or an entire periphery of an inner peripheral face of the bag main body connecting side base portion of the inlet/outlet spout.

摘要翻译： 根据本发明的流体容纳袋包括袋主体，该袋主体由前后两片构成，除了一部分外，其整个外周均被气密密封，其一端侧连接到一个的入口/出口喷口 其另一端侧延伸到袋主体的外侧，用于封闭入口/出口喷口的入口/出口的装置，以及附着到内/外口的内周面的一部分或全周的加强带 该袋主体连接入口/出口喷口的侧基部。

公开(公告)号：US20130123500A1

公开(公告)日：2013-05-16

申请号：US13812437

申请日：2011-07-29

申请人： Toshio Nakamura ,  Kazunari Sakagami ,  Kazuhide Konishi ,  Kanako Yamamoto ,  Seiji Masuda ,  Yohei Matsuda ,  Kumiko Okada ,  Tsuyoshi Shibata ,  Hiroshi Ohta ,  Akito Yasuhara ,  Hiroshi Kawamoto

发明人： Toshio Nakamura ,  Kazunari Sakagami ,  Kazuhide Konishi ,  Kanako Yamamoto ,  Seiji Masuda ,  Yohei Matsuda ,  Kumiko Okada ,  Tsuyoshi Shibata ,  Hiroshi Ohta ,  Akito Yasuhara ,  Hiroshi Kawamoto

IPC分类号： C07D231/12 ,  C07D231/20 ,  C07D231/38 ,  C07D403/06 ,  C07D401/06

CPC分类号： C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D231/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04

摘要： Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like.

摘要翻译： 本发明提供由式[I]表示的新化合物或其对II类代谢型谷氨酸（m-Glu）受体具有拮抗作用的药学上可接受的盐。 化合物或其药学上可接受的盐可用作疾病的预防或治疗剂，例如新的情绪障碍（抑郁和双相性精神障碍），焦虑症（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症， 创伤性应激障碍，特异性恐惧症和急性应激障碍），精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，药物依赖，惊厥，震颤，疼痛，睡眠障碍等。

公开(公告)号：US20120022064A1

公开(公告)日：2012-01-26

申请号：US13144591

申请日：2010-02-05

申请人： Toshio Nakamura ,  Seiji Masuda ,  Aya Futamura

发明人： Toshio Nakamura ,  Seiji Masuda ,  Aya Futamura

IPC分类号： A61K31/4709 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/506 ,  A61K31/444 ,  A61P25/28 ,  A61P25/00 ,  A61P25/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P25/24 ,  A61P37/08 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A dihydroquinolinone derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein Q represents the following formula (A) or (B)}

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的二氢喹啉酮衍生物或其药学上可接受的盐：{其中Q表示下式（A）或（B）}

公开(公告)号：US20110236995A1

公开(公告)日：2011-09-29

申请号：US13132551

申请日：2009-12-03

申请人： Kiyoko Hirano ,  Toshio Nakamura ,  Junko Amano

发明人： Kiyoko Hirano ,  Toshio Nakamura ,  Junko Amano

IPC分类号： G01N33/53 ,  G01N30/02 ,  H01J49/26

CPC分类号： G01N33/57434 ,  G01N30/7233 ,  G01N33/57469 ,  G01N33/6848 ,  G01N2030/8831

摘要： The present invention provides a method for detecting a glycan structure of a prostate specific antigen (PSA) rapidly and with high sensitivity and determining prostate carcinoma based on the difference in the structure, in particular, a method for determining between prostate carcinoma and benign prostatic hyperplasia accurately. A method for determining prostate carcinoma, wherein the method includes a step of analyzing a PSA glycan structure in a sample derived from a test subject, and prostate carcinoma is determined in the case that amount of a glycan having LacdiNAc (N-acetylgalactosamine-N-acetylglucosamine) (LacdiNAc(+)) is more than 30% of amount of a glycan not having LacdiNAc but having LacNAc (galacotose-N-acetylglucosamine) (LacdiNAc(−)). Especially, a method for determining prostate carcinoma, wherein prostate carcinoma is determined in the case that amount of a glycan having LacdiNAc (N-acetylgalactosamine-N-acetylglucosamine) (LacdiNAc(+)) is more than 30% of amount of a glycan not having LacdiNAc but having LacNAc (galacotose-N-acetylglucosamine) (LacdiNAc(−)), and benign prostatic hyperplasia is determined in the case of 30% or less.

摘要翻译： 本发明提供了一种基于结构差异，特别是前列腺癌和良性前列腺增生之间的测定方法，快速且高灵敏度地检测前列腺特异性抗原（PSA）的聚糖结构的方法， 准确。 一种用于测定前列腺癌的方法，其中所述方法包括分析来源于测试受试者的样品中的PSA聚糖结构的步骤，并且在具有LacdiNAc（N-乙酰半乳糖胺-N- 乙酰氨基葡萄糖）（LacdiNAc（+））超过30％的不具有LacdiNAc但具有LacNAc（galacotose-N-乙酰葡糖胺）（LacdiNAc（ - ））的聚糖的量。 特别是一种用于测定前列腺癌的方法，其中在具有LacdiNAc（N-乙酰半乳糖胺-N-乙酰葡糖胺）（LacdiNAc（+））的多糖的量超过多聚糖量的30％的情况下，确定前列腺癌 具有LacdiNAc但具有LacNAc（galacotose-N-乙酰葡糖胺）（LacdiNAc（ - ））），并且在30％以下的情况下测定良性前列腺增生。

公开(公告)号：US07601734B2

公开(公告)日：2009-10-13

申请号：US11578169

申请日：2005-04-08

申请人： Toshihito Kumagai ,  Toshio Nakamura ,  Yuri Amada ,  Yoshinori Sekiguchi

发明人： Toshihito Kumagai ,  Toshio Nakamura ,  Yuri Amada ,  Yoshinori Sekiguchi

IPC分类号： A61K31/44 ,  A61P25/18 ,  A61P25/24

CPC分类号： C07D491/048 ,  C07D471/04 ,  C07D495/04

摘要： An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of α2C-adrenoceptor and is useful in preventing and treating disorders attributable to α2C-adrenoceptor.The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.

摘要翻译： 本发明的目的是提供对α2C-肾上腺素能受体的结合具有强效抑制作用的环胺化合物，可用于预防和治疗归因于α2C-肾上腺素受体的病症。 上述目的通过以下环胺化合物等来解决，其中X是O，S，SO，SO 2或NR 2等; R1是氢原子，氰基，羧基，C2-C13烷氧基羰基，氨基甲酰基等; Ar 1和Ar 2相同或不同，各自表示可被1〜3个取代基等取代的芳基或杂芳基; 环B为苯环可被1〜3个取代基取代等; n是1至10的整数; p和q相同或不同，各自表示1或2的整数。

公开(公告)号：US20070244145A1

公开(公告)日：2007-10-18

申请号：US11578169

申请日：2005-04-08

申请人： Toshihito Kumagai ,  Toshio Nakamura ,  Yuri Amada ,  Yoshinori Sekiguchi

发明人： Toshihito Kumagai ,  Toshio Nakamura ,  Yuri Amada ,  Yoshinori Sekiguchi

IPC分类号： A61K31/44 ,  A61P25/18 ,  A61P25/24

CPC分类号： C07D491/048 ,  C07D471/04 ,  C07D495/04

摘要： An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of α2C-adrenoceptor and is useful in preventing and treating disorders attributable to α2C-adrenoceptor. The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.

摘要翻译： 本发明的目的是提供对α2C-肾上腺素能受体的结合具有强效抑制作用的环胺化合物，可用于预防和治疗归因于α2C-肾上腺素受体的病症。 上述目的通过以下环胺化合物等来解决，其中X是O，S，SO，SO 2或NR 2等; R 1是氢原子，氰基，羧基，C 1 -C 13烷氧基羰基，氨基甲酰基等 。 Ar 1和Ar 2相同或不同，各自表示可被1至3个取代基等取代的芳基或杂芳基; 环B为苯环可被1〜3个取代基取代等; n是1至10的整数; p和q相同或不同，各自表示1或2的整数。

公开(公告)号：US07020890B1

公开(公告)日：2006-03-28

申请号：US09521240

申请日：2000-04-05

申请人： Eiji Suematsu ,  Tamotsu Aoki ,  Yasuo Ogata ,  Masami Suzuki ,  Toshio Nakamura ,  Yoshinori Seki

发明人： Eiji Suematsu ,  Tamotsu Aoki ,  Yasuo Ogata ,  Masami Suzuki ,  Toshio Nakamura ,  Yoshinori Seki

IPC分类号： H04N7/18

CPC分类号： H04H20/61 ,  H04H20/02 ,  H04H20/06 ,  H04N5/63 ,  H04N7/20

摘要： In order to receive satellite broadcasting (BS and CS) and terrestrial broadcasting (VHF and UHF), complicated wiring is required in a personal residence for transmitting broadcasting signals to a plurality of TV receivers while new distributors must be additionally set for installing additional TV receivers in a condominium previously provided with distributors limiting the number of settable TV receivers. The inventive millimeter wave communication system forms power supply paths by simply connecting a BS/CS antenna with a millimeter wave transmitter and connecting an electronic apparatus such as a TV receiver with a millimeter wave receiver through connectors or the like while transmitting/receiving broadcasting signals by millimeter wave radio communication without employing wires such as coaxial cables indoors.

摘要翻译： 为了接收卫星广播（BS和CS）和地面广播（VHF和UHF），在个人住所需要复杂的布线，用于向多个TV接收机发送广播信号，而新的分配器必须另外设置用于安装附加的TV接收机 在以前提供限制可设置的电视接收机的数量的分配器的公寓中。 本发明的毫米波通信系统通过简单地将BS / CS天线与毫米波发射机连接起来形成电源路径，并且通过连接器等通过连接器等将诸如TV接收机的电子设备与毫米波接收机连接起来，同时通过 毫米波无线电通信，而不使用室内同轴电缆等电线。

公开(公告)号：US06917761B2

公开(公告)日：2005-07-12

申请号：US10098342

申请日：2002-03-18

申请人： Toshio Nakamura

发明人： Toshio Nakamura

IPC分类号： H04B10/079 ,  H04B10/293 ,  H04B10/296 ,  H04B10/564 ,  H04B10/572 ,  H04J3/04 ,  H04J14/02 ,  H04J14/08 ,  H04B10/04

CPC分类号： H04J14/08 ,  H04B10/00 ,  H04J14/0221 ,  H04J14/0226 ,  H04J14/0246 ,  H04J14/025 ,  H04J14/0279

摘要： An optical multiplexing apparatus converts input signals from multiple channels to an optical signal including optical pulses multiplexed on the time axis, transmits the optical signal, and controls the average power of the transmitted optical signal so as to maintain constant transmission quality even if the input signal on one or more channels is lost. For example, the average power may be held at a target value that varies according to the combined duty cycle of the multiplexed optical pulses. Alternatively, the average optical power may be held constant and dummy signals may be inserted to replace lost input signals, or to fill idle channels until signal input begins.

摘要翻译： 光复用装置将来自多个通道的输入信号转换成包括在时间轴上复用的光脉冲的光信号，发送光信号，并且控制所发送的光信号的平均功率，以便即使输入信号 一个或多个通道丢失。 例如，平均功率可以保持在根据复用的光脉冲的组合占空比而变化的目标值。 或者，平均光功率可以保持不变，并且可以插入虚拟信号以替换丢失的输入信号，或者填充空闲信道直到信号输入开始。

公开(公告)号：US06627364B2

公开(公告)日：2003-09-30

申请号：US09558595

申请日：2000-04-26

申请人： Hiroshi Kiguchi ,  Satoru Miyashita ,  Toshio Nakamura ,  Tsuyoshi Watanabe

发明人： Hiroshi Kiguchi ,  Satoru Miyashita ,  Toshio Nakamura ,  Tsuyoshi Watanabe

IPC分类号： G02B520

CPC分类号： C09D11/36 ,  C09D11/101 ,  G02B5/201

摘要： A resin composition for producing a color filter by an ink jet system contains (A) a colorant, (B) a binder resin and (c) a solvent having a boiling point of 245° C. or more at normal pressure, wherein the color filter is produced by discharging the above resin composition from an ink jet head into light transmitting regions on the surface of a transparent substrate having banks formed thereon to store the resin composition in the light transmitting regions defined by the banks; forming a pixel pattern by drying the resin composition stored in the light transmitting regions; and forming a protective layer to cover the pixel pattern.

摘要翻译： 用于通过喷墨系统生产滤色器的树脂组合物含有（A）着色剂，（B）粘合剂树脂和（c）常压下沸点为245℃或更高的溶剂，其中颜色 通过将上述树脂组合物从喷墨头排出到在其上形成有堤的透明基板的表面上的透光区域中以将树脂组合物存储在由堤形成的透光区域中来生产滤光器; 通过干燥存储在透光区域中的树脂组合物形成像素图案; 并形成保护层以覆盖像素图案。