公开(公告)号：US08376934B2

公开(公告)日：2013-02-19

申请号：US13092702

申请日：2011-04-22

申请人： Kazuhiko Takahashi ,  Toshio Nakamura

发明人： Kazuhiko Takahashi ,  Toshio Nakamura

IPC分类号： A61B1/00 ,  A61B1/04 ,  G06F3/033

CPC分类号： B25J9/06 ,  A61B1/00147 ,  A61B1/0052 ,  A61B1/0055 ,  A61B5/065 ,  A61B34/30 ,  A61B34/37 ,  A61B2034/2059 ,  A61B2034/306 ,  A61B2090/064

摘要： A multijoint manipulator apparatus includes a tubular-member, linear-motion-transmission-members, a drive-unit, a position-detector, a tension-detector, an operation-unit, and a movement-degree-calculation-unit. The linear-members are inserted in the tubular-member, one end and the other end of each of the linear-members being fixed to the vicinity of a joint of the tubular-member and the drive-unit, respectively. The drive-unit moves the linear-members. The position-detector and the tension-detector detect positions and tension of the linear-members, respectively. A desired position/posture of a point of interest is input to the operation-unit. The calculation-unit calculates a current position/posture of the point, a weighting factor serving to give priority to and move the linear-members the tension of which is relatively low among the linear-members, and movement degrees of the linear-members to move the point to the desired position/posture, and causes the drive-unit to pull the linear-members.

摘要翻译： 多关节机械手装置包括管状构件，直线运动传递构件，驱动单元，位置检测器，张力检测器，操作单元和移动程度计算单元。 线性构件插入管状构件中，每个线性构件的一端和另一端分别固定在管状构件和驱动单元的接头附近。 驱动单元移动线性元件。 位置检测器和张力检测器分别检测线性元件的位置和张力。 将感兴趣点的期望位置/姿势输入到操作单元。 计算单元计算点的当前位置/姿势，用于优先使线性构件中的线性构件的张力相对较低的直线构件的加权系数和线性构件的移动度向 将点移动到期望的位置/姿势，并且使驱动单元拉动线性构件。

公开(公告)号：US20090227834A1

公开(公告)日：2009-09-10

申请号：US12400917

申请日：2009-03-10

申请人： Koji Nakamoto ,  Toshio Nakamura ,  Kazuhiko Takahashi ,  Michifumi Yoshie

发明人： Koji Nakamoto ,  Toshio Nakamura ,  Kazuhiko Takahashi ,  Michifumi Yoshie

IPC分类号： A61B18/14 ,  A61B1/012

CPC分类号： A61B18/148 ,  A61B18/1402 ,  A61B18/1492 ,  A61B34/30 ,  A61B2018/00595 ,  A61B2018/00642 ,  A61B2018/00982 ,  A61B2018/1412 ,  A61B2090/064 ,  A61B2090/065

摘要： An energy surgical device is provided with a treatment section which treats a subject, an energy supply section which supplies energy to the treatment section, a state-change detecting section which detects a state change of the treatment section, an energy instruction input section which inputs an instruction for the energy supply, and a regulation section which regulates the energy supply by the energy supply section based on the input of the energy supply instruction through the energy instruction input section and a result of detection in the state-change detecting section.

摘要翻译： 能量手术装置具有处理对象的治疗部，向治疗部供给能量的能量供给部，检测治疗部的状态变化的状态变化检测部，能够进行输入的能量指示输入部 能量供给指令，以及调节部，其基于通过能量指示输入部的能量供给指示的输入和状态变化检测部的检测结果来调节能量供给部的能量供给。

公开(公告)号：US09101339B2

公开(公告)日：2015-08-11

申请号：US12549779

申请日：2009-08-28

申请人： Kazuhiko Takahashi ,  Toshio Nakamura

发明人： Kazuhiko Takahashi ,  Toshio Nakamura

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B17/00 ,  A61B19/00 ,  A61B1/018 ,  A61B17/29 ,  A61B18/14

CPC分类号： A61B17/00234 ,  A61B1/00133 ,  A61B1/018 ,  A61B17/29 ,  A61B18/1492 ,  A61B34/70 ,  A61B34/72 ,  A61B34/74 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2090/0811

摘要： An endoscope apparatus includes an accessory including an actuation portion configured to be actuated, an operating unit for operating the actuation portion, an endoscope including an accessory insertion pass wherein the accessory is adapted to be inserted through the accessory insertion pass from a proximal end portion of the accessory insertion pass to a distal end portion of the accessory insertion pass, and projected from and retracted into the distal end portion of the accessory insertion pass, a detecting unit configured to detect a condition of a part of the accessory, which is projected from the distal end portion of the accessory insertion pass, and a control unit configured to control an actuation of the actuation portion by an operation to the operating detecting unit.

摘要翻译： 一种内窥镜装置，包括：附件，包括构造成被致动的致动部分，用于操作致动部分的操作单元，包括附件插入通道的内窥镜，其中所述附件适于通过所述附件插入通道从所述附件插入通道的近端部分 所述附件插入通过所述附件插入路径的前端部，并且从所述附件插入路径的前端部突出并缩回到所述附件插入路径的前端部，所述检测单元被配置为检测所述附件的一部分的状态， 附件插入通道的远端部分，以及控制单元，其被配置为通过对操作检测单元的操作来控制致动部分的致动。

公开(公告)号：US20090143642A1

公开(公告)日：2009-06-04

申请号：US12259660

申请日：2008-10-28

申请人： Kazuhiko Takahashi ,  Toshio Nakamura

发明人： Kazuhiko Takahashi ,  Toshio Nakamura

IPC分类号： A61B1/018

CPC分类号： A61B1/018 ,  A61B1/00133 ,  A61B1/00147 ,  A61B1/0055 ,  A61B1/0057 ,  A61B17/00234 ,  A61B17/29 ,  A61B18/14 ,  A61B34/70 ,  A61B2017/00292 ,  A61B2090/064

摘要： A therapeutic device system is provided with a control parameter section for calculating a control parameter for adjusting a drive amount of a manipulator with respect to a manipulation signal on the basis of curved state information on an endoscope insertion section, and changing the old control parameter, and when a state of a curve of the endoscope insertion section has changed, a control parameter conforming to the change is calculated to change the old one, whereby the same manipulation operation of the operator enables the same operation of the manipulator to be performed at all times.

摘要翻译： 治疗装置系统具有控制参数部分，用于基于内窥镜插入部分上的弯曲状态信息来计算用于调节相对于操作信号的操纵器的驱动量的控制参数，并且改变旧的控制参数， 并且当内窥镜插入部的曲线的状态发生变化时，计算出符合该变化的控制参数以改变旧的控制参数，由此操作者的相同的操作操作使得能够完全相同的操纵器的操作 次

公开(公告)号：US08642626B2

公开(公告)日：2014-02-04

申请号：US13812437

申请日：2011-07-29

申请人： Toshio Nakamura ,  Kazunari Sakagami ,  Kazuhide Konishi ,  Kanako Yamamoto ,  Seiji Masuda ,  Yohei Matsuda ,  Kumiko Okada ,  Tsuyoshi Shibata ,  Hiroshi Ohta ,  Akito Yasuhara ,  Hiroshi Kawamoto

发明人： Toshio Nakamura ,  Kazunari Sakagami ,  Kazuhide Konishi ,  Kanako Yamamoto ,  Seiji Masuda ,  Yohei Matsuda ,  Kumiko Okada ,  Tsuyoshi Shibata ,  Hiroshi Ohta ,  Akito Yasuhara ,  Hiroshi Kawamoto

IPC分类号： A61K31/4439 ,  A61K31/415 ,  C07D231/12 ,  C07D231/20 ,  C07D231/38 ,  C07D403/06 ,  C07D401/06

CPC分类号： C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D231/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04

摘要： Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like.

摘要翻译： 本发明提供由式[I]表示的新化合物或其对II类代谢型谷氨酸（m-Glu）受体具有拮抗作用的药学上可接受的盐。 化合物或其药学上可接受的盐可用作疾病的预防或治疗剂，例如新的情绪障碍（抑郁和双相性精神障碍），焦虑症（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症， 创伤性应激障碍，特异性恐惧症和急性应激障碍），精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，药物依赖，惊厥，震颤，疼痛，睡眠障碍等。

公开(公告)号：US20130137865A1

公开(公告)日：2013-05-30

申请号：US13814869

申请日：2011-08-11

申请人： Toshio Nakamura ,  Kazunari Sakagami ,  Kazuhide Konishi ,  Kanako Yamamoto ,  Seiji Masuda ,  Yohei Matsuda ,  Kumiko Okada ,  Tsuyoshi Shibata ,  Hiroshi Ohta ,  Akito Yasuhara ,  Hiroshi Kawamoto ,  Hideaki Amada ,  Hiroki Urabe ,  Rie Nishikawa ,  Shuhei Kashiwa ASHIWA

发明人： Toshio Nakamura ,  Kazunari Sakagami ,  Kazuhide Konishi ,  Kanako Yamamoto ,  Seiji Masuda ,  Yohei Matsuda ,  Kumiko Okada ,  Tsuyoshi Shibata ,  Hiroshi Ohta ,  Akito Yasuhara ,  Hiroshi Kawamoto ,  Hideaki Amada ,  Hiroki Urabe ,  Rie Nishikawa ,  Shuhei Kashiwa ASHIWA

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D403/04 ,  C07D231/38

CPC分类号： C07D413/14 ,  C07D231/38 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04

摘要： A compound represented by formula [I] and a pharmaceutically accepted salt of said compound are a novel compound and a pharmaceutically accepted salt thereof which exert antagonistic activity against group II metabotropic glutamate (mGlu) receptors, and are effective as a novel preventive or therapeutic agent for disorders such as mood disorders (depressive disorder, bipolar disorder, etc.), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, a specific phobic disorder, acute stress disorder, etc.), schizophrenia, Alzheimer's disease, cognitive impairment, dementia, drug dependence, convulsions, shivering, pain, sleep disorders, and the like.

摘要翻译： 由式[I]表示的化合物和所述化合物的药学上可接受的盐是对II族代谢型谷氨酸（mGlu）受体具有拮抗作用的新化合物及其药学上可接受的盐，并且作为新的预防或治疗剂是有效的 用于诸如情绪障碍（抑郁障碍，双相情感障碍等），焦虑障碍（广泛性焦虑症，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特异性恐怖症，急性应激障碍等） ，精神分裂症，阿尔茨海默病，认知障碍，痴呆，药物依赖，抽搐，发抖，疼痛，睡眠障碍等。

公开(公告)号：US08282543B2

公开(公告)日：2012-10-09

申请号：US12573201

申请日：2009-10-05

申请人： Tsutomu Ishiguro ,  Toshio Nakamura ,  Jun Hasegawa

发明人： Tsutomu Ishiguro ,  Toshio Nakamura ,  Jun Hasegawa

IPC分类号： A61B1/00

CPC分类号： A61B17/29 ,  A61B18/1445 ,  A61B18/1477 ,  A61B18/1492 ,  A61B34/70 ,  A61B34/71 ,  A61B34/74 ,  A61B2017/003 ,  A61B2017/00318 ,  A61B2017/0034 ,  A61B2017/00398 ,  A61B2017/2927 ,  A61B2017/2939 ,  A61B2017/320072 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2034/742

摘要： A surgical instrument having a surgical unit which operates on an operating portion in a body cavity, an accommodation portion capable of accommodating the surgical unit. The surgical instrument having movement manipulation mechanism connected to the surgical unit for moving the surgical unit to a position at which the surgical unit is accommodated in the accommodation portion and to a position at which the surgical unit is exposed from the accommodation portion along the inside of the accommodation portion.

摘要翻译： 一种具有在体腔内的操作部分上操作的手术单元的手术器械，能够容纳外科单元的容纳部分。 该外科器具具有连接到外科单元的移动操作机构，用于将手术单元移动到手术单元容纳在容纳部分中的位置，以及外科单元沿着容纳部分沿着内窥镜 住宿部分。

公开(公告)号：US20090291940A1

公开(公告)日：2009-11-26

申请号：US12296082

申请日：2007-03-30

申请人： Taketoshi Okubo ,  Toshihito Kumagai ,  Takaaki Ishii ,  Toshio Nakamura ,  Kumi Abe ,  Yuri Amada ,  Tomoko Ishizaka ,  Xiang-Min Sun ,  Yoshinori Sekiguchi ,  Shigetada Sasako ,  Takanori Shimizu ,  Takayuki Nagatsuka

发明人： Taketoshi Okubo ,  Toshihito Kumagai ,  Takaaki Ishii ,  Toshio Nakamura ,  Kumi Abe ,  Yuri Amada ,  Tomoko Ishizaka ,  Xiang-Min Sun ,  Yoshinori Sekiguchi ,  Shigetada Sasako ,  Takanori Shimizu ,  Takayuki Nagatsuka

IPC分类号： A61K31/553 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/517 ,  A61K31/4709 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14

CPC分类号： C07D401/12

摘要： Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.

摘要翻译： 公开了由式[I]表示的氨基吡咯烷化合物或其药学上可接受的盐。 化合物或盐可用作模式障碍如抑郁症，焦虑障碍，厌食症，恶病质，疼痛和药物依赖性的预防/治疗剂，其作用依赖于MC4受体拮抗作用。

公开(公告)号：US20060204158A1

公开(公告)日：2006-09-14

申请号：US10567568

申请日：2004-08-06

申请人： Kazuto Kobayashi ,  Toshio Nakamura ,  Keiichi Horino ,  Yoshiro Ide

发明人： Kazuto Kobayashi ,  Toshio Nakamura ,  Keiichi Horino ,  Yoshiro Ide

IPC分类号： F16C33/52

CPC分类号： F16C33/4682 ,  B21D53/12 ,  F16C19/38 ,  F16C23/086 ,  F16C33/543 ,  Y10T29/49686 ,  Y10T29/49687 ,  Y10T29/49691

摘要： A method of manufacturing a retainer for a roller bearing made of a metal plate and has a tubular main portion, pockets formed in the main portion intermittently concerning a circumferential direction and capable of retaining rollers rollably, and an outwardly oriented flange-like collar portion. An annular intermediate material is formed by die cutting the metal plate, and after a second intermediate material is formed by forming through holes in the intermediate material intermittently, a portion of the second intermediate material excluding a radially outer end portion is plastically deformed into a tubular shape. The portion plastically deformed tubular shape is formed as the main portion, a portion corresponding to the radially outer end portion of the second intermediate material is formed as the collar portion or a collar portion element for forming the collar portion, and portions corresponding to the through holes are formed as the pockets.

摘要翻译： 一种制造用于由金属板制成的滚子轴承的保持器的方法，并且具有管状主体部分，在主体部分中间歇地形成有围绕圆周方向并且能够滚动地保持辊的口袋和向外定向的凸缘状套环部分。 通过对金属板进行模切而形成环状的中间材料，在间歇地形成中间材料的贯通孔而形成第二中间材料之后，除了径向外端部以外的部分第二中间材料塑性地变形为管状 形状。 形成塑性变形管状的部分形成为主要部分，对应于第二中间材料的径向外端部的部分形成为套环部分或用于形成套环部分的套环部分元件，以及对应于贯穿 孔形成为袋。

公开(公告)号：US06476056B2

公开(公告)日：2002-11-05

申请号：US09922807

申请日：2001-08-07

申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Toshio Nakamura ,  Shigeyuki Chaki ,  Kazuyuki Tomisawa ,  Masashi Nagamine ,  Kenji Yamamoto ,  Koichiro Harada ,  Masanori Yoshida

发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Toshio Nakamura ,  Shigeyuki Chaki ,  Kazuyuki Tomisawa ,  Masashi Nagamine ,  Kenji Yamamoto ,  Koichiro Harada ,  Masanori Yoshida

IPC分类号： A61K3144

CPC分类号： C07D213/40 ,  C07C233/25 ,  C07C233/33 ,  C07C233/54 ,  C07C235/38 ,  C07C235/78 ,  C07C237/30 ,  C07C247/10 ,  C07C275/32 ,  C07C311/27 ,  C07C311/29 ,  C07C311/46 ,  C07C323/20 ,  C07C323/41 ,  C07C323/60 ,  C07D213/643 ,  C07D213/65 ,  C07D213/68

摘要： An aryloxyaniline derivative represented by the formula: wherein Ar1 and Ar2 are the same or different, and are each a substituted or unsubstituted phenyl group, a substituted or unsubstituted pyridyl group or a naphthyl group, provided that Ar1 and Ar2 are not both phenyl or both naphthyl and are not phenyl and naphthyl, R1 is a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, an alkoxy group having 1 to 10 carbon atoms, a substituted or unsubstituted phenyl group or a group of the formula: —NR2(R3) (wherein R2 and R3 are the same or different, and are each a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, X1 is a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a halogen atom, a trifluoromethyl group, a carbamoyl group or an aminosulfonyl group, Y1 is a branched or unbranched alkylene group having 1 to 6 carbon atoms or a single bond; and pharmaceutically acceptable salts thereof.

摘要翻译： 由下式表示的芳氧基苯胺衍生物：其中Ar1和Ar2相同或不同，并且各自为取代或未取代的苯基，取代或未取代的吡啶基或萘基，条件是Ar 1和Ar 2不同时为苯基或两者 萘基，不是苯基和萘基，R1是氢原子，取代或未取代的碳原子数1〜10的烷基，碳原子数1〜10的烷氧基，取代或未取代的苯基或下式的基团： -NR2（R3）（其中R2和R3相同或不同，并且各自为氢原子或具有1-10个碳原子的烷基，X 1为氢原子，具有1至5个碳原子的烷基， 具有1至5个碳原子的烷氧基，苯氧基，卤素原子，三氟甲基，氨基甲酰基或氨基磺酰基，Y1是具有1至6个碳原子或单键的支链或非支链亚烷基; 可以接受 的盐。