-
公开(公告)号：US08962764B2
公开(公告)日：2015-02-24
申请号：US13260504
申请日：2010-03-29
Applicant: Krzysztof Matyjaszewski , Haifeng Gao , James Spanswick
Inventor： Krzysztof Matyjaszewski , Haifeng Gao , James Spanswick
IPC: C08F290/02 , C08F293/00 , C08F8/00 , C08J3/28
CPC classification number: C08F290/02 , C08F293/00
Abstract: A process for constructing multi-arm star macromolecules with uniform properties, high molecular weight and narrow molecular weight distribution using free radical polymerization is described.
Abstract translation: 描述了使用自由基聚合构建具有均匀性质，高分子量和窄分子量分布的多臂星型大分子的方法。
-
公开(公告)号：US20120077899A1
公开(公告)日：2012-03-29
申请号：US13260504
申请日：2010-03-29
Applicant: Krzysztof Matyjaszewski , Haifeng Gao , James Spanswick
Inventor： Krzysztof Matyjaszewski , Haifeng Gao , James Spanswick
CPC classification number: C08F290/02 , C08F293/00
Abstract: A process for constructing multi-arm star macromolecules with uniform properties, high molecular weight and narrow molecular weight distribution using free radical polymerization is described.
Abstract translation: 描述了使用自由基聚合构建具有均匀性质，高分子量和窄分子量分布的多臂星型大分子的方法。
-
公开(公告)号：US20110060107A1
公开(公告)日：2011-03-10
申请号：US12877589
申请日：2010-09-08
Applicant: Krzysztof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
Inventor： Krzysztof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
IPC: C08F8/30
CPC classification number: C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
Abstract: The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials.Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form block copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
Abstract translation: 本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。 本发明的一个实施方案包括对聚合物进行点击化学反应。 优选地，通过控制聚合方法制备聚合物。 因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。 官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。 本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。
-
34.发明授权Amide and/or imide containing polymers and monomers for the preparation thereof 失效含酰胺和/或酰亚胺的聚合物和单体用于制备它们
公开(公告)号：US5032667A
公开(公告)日：1991-07-16
申请号：US453783
申请日：1989-12-20
Applicant: James E. Harris , Abe Berger , Vilas M. Chopdekar , Markus Matzner , James Spanswick
Inventor： James E. Harris , Abe Berger , Vilas M. Chopdekar , Markus Matzner , James Spanswick
CPC classification number: C08G73/1078 , C08G73/10 , C08G73/1039 , C08G73/1042 , C08G73/1046 , C08L79/08
Abstract: Described herein are amide and/or imide containing polymers based on novel monomers that contain isoalkylidene bridges. These polymers have excellent toughness combined with high temperature stability, low water absorption, and good melt-fabricability.
Abstract translation: 本文描述了基于含有异亚烷基桥的新型单体的含酰胺和/或酰亚胺的聚合物。 这些聚合物具有优异的韧性以及高温稳定性，低吸水性和良好的熔融制造性。
-
公开(公告)号：US08367051B2
公开(公告)日：2013-02-05
申请号：US12311673
申请日：2007-10-09
Applicant: Krzysztof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
Inventor： Krzysztof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
CPC classification number: C08F293/005 , C08F283/00 , C08F290/00 , C08F290/06 , C08F291/00
Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.
Abstract translation: 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。
-
Patent Agency Ranking
公开(公告)号：US08252880B2
公开(公告)日：2012-08-28
申请号：US12451581
申请日：2008-05-23
Applicant: Krzysztof Matyjaszewski , Ke Min , James Spanswick
Inventor： Krzysztof Matyjaszewski , Ke Min , James Spanswick
IPC: C08F4/00 , C08F2/00 , C08F4/28 , C08F210/00 , C08F36/00
CPC classification number: C08F12/08 , C08F2/14 , C08F2/38 , C08F212/36 , C08F2438/01
Abstract: The present disclosure describes a two-step batch dispersion polymerization process for the preparation of substantially uniformed-sized functional (co)polymer particles. The first step of the process includes polymerizing at least one first radically (co)polymerizable monomer by a free radical polymerization process to form a (co)polymer in a stable colloidal dispersion and the second step includes polymerizing the at first radically (co)polymerizable monomer or an additional radically (co)polymerizable monomer in the stable colloidal dispersion by a living/controlled radical (co)polymerization process.
Abstract translation: 本公开描述了用于制备基本上均匀尺寸的功能（共）聚合物颗粒的两步间歇分散聚合方法。 该方法的第一步包括通过自由基聚合方法聚合至少一种第一自由基（共）可聚合单体，以在稳定的胶态分散体中形成（共）聚合物，第二步包括首先从根本上聚合（共）可聚合 单体或通过活/受控自由基（共）聚合方法在稳定的胶体分散体中的另外的自由基（共）可聚合单体。
-
公开(公告)号：US20110286935A1
公开(公告)日：2011-11-24
申请号：US13109256
申请日：2011-05-17
Applicant: Patrick McCarthy , James Spanswick
Inventor： Patrick McCarthy , James Spanswick
CPC classification number: B82Y5/00 , A61K47/6921 , A61K47/6933 , B82Y15/00 , C08F230/08 , C08F2220/281 , C08F2220/286 , C08F2438/01
Abstract: A universal drug delivery platform for monoclonal antibody-based therapeutics is described. This universal platform resolves the problems of immunogenic response associated with the present monoclonal antibody based therapeutics by providing a multifunctional nano-device which comprises a well defined core/shell nano-structure that can function as a drug delivery platform linked to a monoclonal antibody through a single linking group.
Abstract translation: 描述了用于基于单克隆抗体的治疗剂的通用药物递送平台。 该通用平台通过提供多功能纳米装置来解决与本发明的基于单克隆抗体的治疗相关的免疫原性应答的问题，该多功能纳米装置包含明确定义的核/壳纳米结构，其可以作为通过以下方式与单克隆抗体连接的药物递送平台 单链接组。
-
公开(公告)号：US07795355B2
公开(公告)日：2010-09-14
申请号：US10591425
申请日：2005-03-07
Applicant: Krzyszlof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
Inventor： Krzyszlof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
IPC: C08F8/30
CPC classification number: C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
Abstract: The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
Abstract translation: 本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。 本发明的一个实施方案包括对聚合物进行点击化学反应。 优选地，通过受控聚合方法制备聚合物。 因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。 官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。 本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。
-
公开(公告)号：US20100143286A1
公开(公告)日：2010-06-10
申请号：US12311673
申请日：2007-10-09
Applicant: Krzystof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
Inventor： Krzystof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
CPC classification number: C08F293/005 , C08F283/00 , C08F290/00 , C08F290/06 , C08F291/00
Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.
Abstract translation: 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。
-
公开(公告)号：US20070244265A1
公开(公告)日：2007-10-18
申请号：US10591425
申请日：2005-03-07
Applicant: Krzyszlof Matyjaszewski , Brent Sumerlin , Nicolay Tsarvsky , James Spanswick
Inventor： Krzyszlof Matyjaszewski , Brent Sumerlin , Nicolay Tsarvsky , James Spanswick
IPC: C08F8/30 , C08F226/06 , C08F4/619 , C08F8/00
CPC classification number: C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
Abstract: The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
Abstract translation: 本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。 本发明的一个实施方案包括对聚合物进行点击化学反应。 优选地，通过控制聚合方法制备聚合物。 因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。 官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。 本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。
-
-
-
-
-
-
-
-
-
Search Results
43
records
(took 0.027 seconds)
