公开(公告)号：US06277833B1

公开(公告)日：2001-08-21

申请号：US09160776

申请日：1998-09-24

申请人： Rolf Angerbauer ,  Peter Fey ,  Walter Hübsch ,  Thomas Philipps ,  Hilmar Bischoff ,  Hans-Peter Krause ,  Jörg Petersen von Gehr ,  Delf Schmidt

发明人： Rolf Angerbauer ,  Peter Fey ,  Walter Hübsch ,  Thomas Philipps ,  Hilmar Bischoff ,  Hans-Peter Krause ,  Jörg Petersen von Gehr ,  Delf Schmidt

IPC分类号： C07D207333

CPC分类号： C07F9/6561 ,  C07C33/28 ,  C07C33/36 ,  C07C33/38 ,  C07C69/013 ,  C07D209/12 ,  C07F9/3211

摘要： Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.

摘要翻译： 取代的三醇通过还原适当取代的羧酸酯来制备。 取代的三醇可用作药物中的活性物质。

公开(公告)号：US5780389A

公开(公告)日：1998-07-14

申请号：US534234

申请日：1995-09-26

申请人： Hans-Peter Krause ,  Thomas Maier ,  Jean-Paul Schoeni ,  Anna Waltersdorfer

发明人： Hans-Peter Krause ,  Thomas Maier ,  Jean-Paul Schoeni ,  Anna Waltersdorfer

IPC分类号： B01J13/02 ,  A01N25/28 ,  A01N43/54 ,  A01N25/02

CPC分类号： A01N25/28 ,  Y10S514/963 ,  Y10S514/971

摘要： The present invention relates to microcapsules containing water-insoluble, liquid active ingredients or mixtures thereof, which are employed principally in the sector of plant protection and in which the solvent which is likewise present within the capsule is a liquid substance comprising two or more aromatic rings. The microencapsulation of plant protection agents, especially the envelopment of water-insoluble, liquid or solid active particles in water-based mixed-phase systems, has developed in recent years to become a standard formulation technique.

摘要翻译： 本发明涉及含有水不溶性，液体活性成分或其混合物的微胶囊，其主要用于植物保护领域，其中同样存在于胶囊内的溶剂是包含两个或多个芳环的液体物质 。 植物保护剂的微胶囊化，特别是水性混合相系统中水不溶性，液体或固体活性颗粒的包封已经近年来发展成为标准配方技术。

公开(公告)号：US5409910A

公开(公告)日：1995-04-25

申请号：US169804

申请日：1993-12-17

申请人： Rolf Angerbauer ,  Peter Fey ,  Walter Hubsch ,  Thomas Philipps ,  Hilmar Bischoff ,  Hans-Peter Krause ,  Jorg P. von Gehr ,  Delf Schmidt

发明人： Rolf Angerbauer ,  Peter Fey ,  Walter Hubsch ,  Thomas Philipps ,  Hilmar Bischoff ,  Hans-Peter Krause ,  Jorg P. von Gehr ,  Delf Schmidt

IPC分类号： A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/445 ,  A61K31/66 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07D213/30 ,  C07D213/48 ,  C07D213/50 ,  C07D213/74 ,  C07D405/06 ,  C07F9/58 ,  A61K31/675 ,  C07D401/00

CPC分类号： C07D213/30 ,  C07D405/06

摘要： New substituted pyridines are prepared by reducing suitably substituted pyridine derivatives. The new substituted pyridines are suitable as active compounds in pharmaceuticals, in particular for the treatment of hyperlipoproteinaemia.

摘要翻译： 通过还原适当取代的吡啶衍生物制备新的取代的吡啶。 新的取代的吡啶适合作为药物中的活性化合物，特别是用于治疗高脂蛋白血症。

公开(公告)号：US5116826A

公开(公告)日：1992-05-26

申请号：US637304

申请日：1991-01-03

申请人： Hans H. Schubert ,  Gerhard Salbeck ,  Hans-Peter Krause ,  Werner Knauf ,  Anna Waltersdorfer ,  Manfred Kern

发明人： Hans H. Schubert ,  Gerhard Salbeck ,  Hans-Peter Krause ,  Werner Knauf ,  Anna Waltersdorfer ,  Manfred Kern

IPC分类号： C07D253/06 ,  A01N43/40 ,  A01N55/00 ,  A01N55/10 ,  C07D213/32 ,  C07D213/61 ,  C07D213/64 ,  C07D213/643 ,  C07D213/70 ,  C07D237/12 ,  C07D237/14 ,  C07D237/18 ,  C07D239/26 ,  C07D239/32 ,  C07D239/34 ,  C07D241/16 ,  C07D241/18 ,  C07D257/08 ,  C07D401/12 ,  C07D409/12 ,  C07D491/056 ,  C07F7/10

CPC分类号： C07D213/64 ,  A01N43/40 ,  A01N55/00 ,  C07D213/643 ,  C07D213/70 ,  C07D409/12

摘要： Azaneophyl and silazaneophyl sulfides, processes for their preparation, agents containing them, and their use as pesticidesCompounds of the formula I, their optical isomers and mixtures thereof ##STR1## where M denotes C or Si,R.sup.1 denotes unsubstituted or substituted pyridyl, unsubstituted or substituted pyrimidyl, andwhen M=C-- denotes unsubstituted or substituted pyridazinyl, unsubstituted or substituted pyrazinyl, unsubstituted or substituted 1,2,4-triazinyl, unsubstituted or substituted 1,2,4,5-tetrazinyl,R.sup.2, R.sup.3 independently of one another denote alkyl, alkenyl, haloalkyl, phenyl, or R.sup.2 and R.sup.3 denote an alkylene chain which--together with the quaternary central atom (M)--form an unsubstituted or fluorine-substituted ring having four to six ring members (when M=Si) or having three to six ring members (when M=C),R.sup.4 denotes H, F, --CN, --CCl.sub.3, --C.dbd.CH, (C.sub.1 -C.sub.4)alkyl, ##STR2## R.sup.5 denotes pyridyl, furyl, thienyl, all of which can be substituted, phthalimidyl, dialkylmaleinimidyl, thiophthalimidyl, dihydrophthalimidyl, tetrahydrophthalimidyl, substituted phenylor R.sup.4 and R.sup.5 --together with the carbon atom bridging them--denote an optionally substituted indanyl, cyclopentenoyl or cyclopentenyl radical,and to their salts and quaternization products for advantageous insecticidal, acaricidal or nematocidal properties.

公开(公告)号：US4466964A

公开(公告)日：1984-08-21

申请号：US424829

申请日：1982-09-27

申请人： Hans-Joachim Kabbe ,  Hans-Peter Krause ,  Rudiger Sitt

发明人： Hans-Joachim Kabbe ,  Hans-Peter Krause ,  Rudiger Sitt

IPC分类号： C07D209/08 ,  C07D215/08 ,  C07D215/18 ,  C07D215/20 ,  C07D279/16 ,  A61K31/54 ,  C07D417/12

CPC分类号： C07D279/16 ,  C07D209/08 ,  C07D215/08 ,  C07D215/18 ,  C07D215/20

摘要： The invention relates to alkylurea derivatives of Formula (I), as defined in the specification, which alkylurea derivatives are useful as hypolipaemic agents. Also included in the invention are methods for the manufacture of said alkylurea derivatives compositions and medicaments containing said alkylurea derivatives and methods for the use of said alkylurea derivatives.

摘要翻译： 本发明涉及如说明书中定义的式（I）的烷基脲衍生物，其中烷基脲衍生物可用作降血糖剂。 本发明还包括制备所述烷基脲衍生物组合物和含有所述烷基脲衍生物的药物的方法和使用所述烷基脲衍生物的方法。

公开(公告)号：US4460607A

公开(公告)日：1984-07-17

申请号：US424828

申请日：1982-09-27

申请人： Hans-Joachim Kabbe ,  Hans-Peter Krause ,  Rudiger Sitt

发明人： Hans-Joachim Kabbe ,  Hans-Peter Krause ,  Rudiger Sitt

IPC分类号： C07D209/08 ,  C07D215/08 ,  C07D215/18 ,  C07D215/20 ,  C07D279/16 ,  A61K31/535 ,  C07D265/36

CPC分类号： C07D279/16 ,  C07D209/08 ,  C07D215/08 ,  C07D215/18 ,  C07D215/20

摘要： The invention relates to alkylurea derivatives of Formula (I), as defined in the specification, which alkylurea derivatives are useful as hypolipaemic agents. Also included in the invention are methods for the manufacture of said alkylurea derivatives compositions and medicaments containing said alkylurea derivatives and methods for the use of said alkylurea derivatives.

摘要翻译： 本发明涉及如说明书中定义的式（I）的烷基脲衍生物，其中烷基脲衍生物可用作降血糖剂。 本发明还包括制备所述烷基脲衍生物组合物和含有所述烷基脲衍生物的药物的方法和使用所述烷基脲衍生物的方法。

公开(公告)号：US4307194A

公开(公告)日：1981-12-22

申请号：US858036

申请日：1977-12-06

申请人： Werner Frommer ,  Lutz Muller ,  Delf Schmidt ,  Walter Puls ,  Hans-Peter Krause ,  Ulrich Heber

发明人： Werner Frommer ,  Lutz Muller ,  Delf Schmidt ,  Walter Puls ,  Hans-Peter Krause ,  Ulrich Heber

IPC分类号： C12P17/12 ,  A23K1/17 ,  A23K1/18 ,  A61K31/445 ,  A61K35/74 ,  C07D211/46 ,  C12N1/20 ,  C12N9/99 ,  C12P1/04 ,  C12P19/26 ,  C12R1/07 ,  C12R1/12 ,  C12R1/125

CPC分类号： C12R1/07 ,  A23K20/195 ,  A23K50/30 ,  A61K31/445 ,  C12N1/20 ,  C12P1/04 ,  Y10S435/832 ,  Y10S435/839

摘要： According to the present invention inhibitors for glycoside hydrolases, and in particular glucosidase inhibitors especially saccharase inhibitors, which are active in the digestive tract are formed by culturing organisms of the family Bacillaceae, particularly by strains of the genus Bacillus.It has also been found that certain strains of organisms of the family Bacillaceae, especially strains DSM 7, DSM 704 and DSM 675 produce the antibiotic known as 1-desoxynojirimycin. The invention therefore provides a method of producing 1-desoxynojirimycin which comprises culturing a 1-desoxynojirimycin producing organism of the genus Bacillus. Inhibitors for glycoside hydrolases and the invention includes methods for producing such inhibitors, pharmaceutical compositions containing the inhibitors and methods of treatment involving the use of the inhibitors.

摘要翻译： 根据本发明，通过培养家蚕科的生物体，特别是通过芽孢杆菌属的菌株形成糖苷水解酶抑制剂，特别是在消化道中有活性的葡糖苷酶抑制剂，特别是糖酶抑制剂。 还已经发现，芽孢杆菌科的特定菌株DSM 7，DSM 704和DSM 675的生物体产生称为1-脱氧野尻霉素的抗生素。 因此，本发明提供了一种生产1-脱氧野尻霉素的方法，该方法包括培养产生芽孢杆菌属的1-脱氧诺伊霉素生物的生物。 糖苷水解酶和本发明的抑制剂包括制备这种抑制剂的方法，含有抑制剂的药物组合物和涉及使用抑制剂的治疗方法。