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公开(公告)号：US20190194184A1
公开(公告)日：2019-06-27
申请号：US16289212
申请日：2019-02-28
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, JR. , Alla Yurevna Zenova
IPC: C07D451/06 , C07D285/08 , C07D277/52 , C07D493/10 , C07D261/16 , C07D417/12 , C07D401/12 , C07D239/69 , C07D237/20 , C07D213/76 , C07D403/12 , C07D417/14 , C07D413/12
Abstract: This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号：US10246453B2
公开(公告)日：2019-04-02
申请号：US15600490
申请日：2017-05-19
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, Jr. , Alla Yurevna Zenova
IPC: A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/444 , C07D417/12 , C07D417/14 , C07D401/12 , C07D401/14 , C07D451/06 , C07D403/12 , C07D213/76 , C07D237/20 , C07D239/69 , C07D413/12 , C07D261/16 , C07D493/10 , C07D277/52 , C07D285/08
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号：US10179767B2
公开(公告)日：2019-01-15
申请号：US15161085
申请日：2016-05-20
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Sultan Chowdhury , Christoph Martin Dehnhardt , Abid Hasan , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Shaoyi Sun , Andrew D. White , Wei Gong , Alla Yurevna Zenova , Jiuxiang Zhu
IPC: A01N43/00 , A61K31/00 , C07D211/22 , C07D211/48 , C07D211/34 , C07D405/08 , C07D401/12 , C07D401/08 , C07D211/42 , C07D221/20 , C07D401/04 , C07D211/38 , C07D211/62
Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US20170334902A1
公开(公告)日：2017-11-23
申请号：US15600490
申请日：2017-05-19
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, JR. , Alla Yurevna Zenova
IPC: C07D451/06 , C07D401/12 , C07D417/12 , C07D417/14
CPC classification number: C07D451/06 , C07D213/76 , C07D237/20 , C07D239/69 , C07D261/16 , C07D277/52 , C07D285/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D493/10
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号：US20170114075A1
公开(公告)日：2017-04-27
申请号：US15253369
申请日：2016-08-31
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: C07D513/22 , C07D491/20 , C07D495/20 , C07D498/20 , C07D491/22 , C07D513/20 , C07D491/107
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：US09630929B2
公开(公告)日：2017-04-25
申请号：US14355552
申请日：2012-10-30
Applicant: XENON PHARMACEUTICALS INC.
Inventor： Shaoyi Sun , Alla Yurevna Zenova , Mikhail Chafeev , Qi Jia , Zaihui Zhang , Renata Marcella Oballa
IPC: C07D417/12 , C07D239/42 , C07D285/08 , C07D401/12 , C07D413/12 , C07D211/22 , C07D257/06 , C07D261/14 , C07D277/52 , C07D285/135
CPC classification number: C07D239/42 , C07D211/22 , C07D257/06 , C07D261/14 , C07D277/52 , C07D285/08 , C07D285/135 , C07D401/12 , C07D413/12 , C07D417/12
Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：US20170002017A1
公开(公告)日：2017-01-05
申请号：US15017282
申请日：2016-02-05
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07C311/51 , C07D307/12 , C07D213/82 , C07D205/04 , C07D207/48 , C07D295/26 , C07D257/04 , C07D311/58 , C07D209/52 , C07D307/18 , C07D211/22 , C07D233/84
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 和其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，B，R1，R2，R3，R4，R5和RN具有本文所述的含义， 化合物和使用这些化合物和组合物的方法。
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公开(公告)号：US20160297754A1
公开(公告)日：2016-10-13
申请号：US15133030
申请日：2016-04-19
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Daniel Ortwine , Brian Safina , Shaoyi Sun , Daniel P. Sutherlin , Alla Yurevna Zenova
IPC: C07C311/51 , C07D213/82 , C07D213/64 , C07D205/04 , C07D471/08 , C07D405/12 , C07D295/26 , C07D233/84 , C07D257/04 , C07D207/46 , C07C307/06 , C07D311/58
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 和其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，B，R1，R2，R3，R4，R5和RN具有本文所述的含义， 化合物和使用这些化合物和组合物的方法。
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