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公开(公告)号：US20090067042A1
公开(公告)日：2009-03-12
申请号：US11667338
申请日：2005-11-09
IPC分类号： G02B21/36
CPC分类号： G02B21/0028 , G02B21/082 , G02B21/361 , G02B21/362
摘要： When carrying out in vivo examination of a living organism, the behavior in the interior thereof is continuously observed with clear images. Provided is an in-vivo examination apparatus 1 comprising an optical unit 4 including a light source 2 and an image acquisition device 3; and an observation head 5, which is disposed with a gap with respect to the optical unit 4 and which is fixed to a living organism A, wherein the optical unit 4 includes a first collimator optical system 7 for converting light from the light source 2 into collimated light L1 and introducing it into the observation head 5 and an image-forming optical system 9 for focusing return light from the observation head 5 to form an image at the image-acquisition device 3, and wherein the observation optical head 5 includes a second collimator optical system 15 for focusing the collimated light L1 incident from the optical unit 4 to irradiate an examination target site B in the living organism A, as well as for converting return light from the living organism into collimated light L2 and introducing it into the optical unit 4.
摘要翻译： 在进行生物体的体内检查时，以清晰的图像连续观察其内部的行为。 提供一种体内检查装置1，其包括：包含光源2和图像获取装置3的光学单元4; 以及观察头5，其相对于光学单元4设置有间隙并且固定在生物体A上，其中光学单元4包括用于将来自光源2的光转换成第一准直光学系统7 准直光L1并将其引入观察头5和用于聚焦来自观察头5的返回光以在图像获取装置3处形成图像的成像光学系统9，并且其中观察光学头5包括第二 用于聚焦从光学单元4入射的准直光L1以照射生物体A中的检查对象部位B的准直器光学系统15，以及将来自活体的返回光转换为准直光L2并将其引入光学 单位4。
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公开(公告)号：US20080130103A1
公开(公告)日：2008-06-05
申请号：US11628762
申请日：2005-06-09
IPC分类号： G02B21/06
CPC分类号： G02B21/22 , A61B5/0059 , A61B5/0068 , A61B2503/40 , G02B21/0036
摘要： A clear image having suppressed blurring due to pulsing is obtained by in-vivo examination of biological tissue or various internal organs of mammals, including small laboratory animals. The invention provides an optical-scanning microscope examination apparatus including a light source; a light-transmitting member for transmitting light from the light source; a collimator optical system for converting the transmitted light to a collimated beam; a beam-scanning unit for scanning the collimated beam on a subject; a focusing optical system for focusing the scanned beam onto the subject; a pupil-projection optical system; a light detector for detecting return light returning from the subject via the focusing optical system, the pupil-projection optical system, the beam-scanning unit, the collimator optical system, and the light-transmitting member; an actuator for moving the collimator optical system in an optical-axis direction; a control apparatus for controlling driving thereof; and a deflecting mechanism for deflecting the light issuing from the light-transmitting member in a direction intersecting the optical axis thereof, wherein the actuator is disposed in a space parallel to a plane including optical axes before and after deflection by the deflecting mechanism.
摘要翻译： 通过对包括小实验室动物在内的哺乳动物的生物组织或各种内部器官的体内检查来获得抑制由于脉冲引起的模糊的清晰图像。 本发明提供一种包括光源的光学扫描显微镜检查装置; 用于从光源透射光的透光构件; 用于将透射光转换成准直光束的准直器光学系统; 用于扫描被摄体上的准直光束的光束扫描单元; 用于将扫描光束聚焦到被摄体上的聚焦光学系统; 瞳孔投影光学系统; 光检测器，用于检测从对象经由聚焦光学系统，瞳孔投影光学系统，光束扫描单元，准直仪光学系统和透光元件返回的返回光; 用于沿准直光学系统沿光轴方向移动的致动器; 用于控制其驱动的控制装置; 以及偏转机构，用于偏转从所述透光部件发出的光沿与其光轴相交的方向，其中所述致动器设置在与所述偏转机构偏转前后包括光轴的平面平行的空间中。
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公开(公告)号：US20080106786A1
公开(公告)日：2008-05-08
申请号：US12001547
申请日：2007-12-11
IPC分类号： G02B21/26
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/6835 , A61B5/6844 , A61B5/6886 , A61B2503/40 , G02B21/0032 , G02B21/0076 , G02B21/16
摘要： An easily viewable examination image in which blurring occurring in an image is reduced without operating an examination optical system in real time matching the motion of a specimen is obtained. There is provided an examination method comprising, prior to examining an examination site of a specimen, acquiring an image of the specimen surface of an examination region including the examination site, over a predetermined time range; extracting a plurality of feature points by processing the acquired image of the specimen surface; calculating a motion trajectory for each of the extracted feature points over the time range; and disposing an optical axis of an examination optical system at a position where the motion trajectory of a feature point disposed in the examination site is minimized.
摘要翻译： 获得其中在图像中发生模糊的轻松可见的检查图像，而不用实际地检查检体光学系统来匹配检体的运动。 提供了一种检查方法，其包括在检查样本的检查部位之前，在预定时间范围内获取包括检查部位的检查区域的样本表面的图像; 通过处理获得的样本表面的图像来提取多个特征点; 在时间范围内计算每个提取的特征点的运动轨迹; 并且将检查光学系统的光轴布置在设置在检查部位的特征点的运动轨迹最小化的位置。
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公开(公告)号：US07304790B2
公开(公告)日：2007-12-04
申请号：US11090036
申请日：2005-03-28
IPC分类号： G02B21/00
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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公开(公告)号：US20070249895A1
公开(公告)日：2007-10-25
申请号：US11730075
申请日：2007-03-29
IPC分类号： A61B10/00
CPC分类号： G02B21/0012 , G02B21/34
摘要： Dynamic movement of various specimens is effectively suppressed, while easily allowing compatibility with various specimens having a wide range of types, sizes, and shapes, and various types of examination methods of specimens. A stabilizer for in vivo examination that is placed in contact with a biological specimen in the vicinity of an observation optical axis during examination of the specimen to suppress movement thereof includes a tip configured to contact the biological specimen, and a movable member configured to support the tip so that the tip can move in a direction intersecting the observation optical axis. The tip is attached to the movable member in such a manner so as to be attachable thereto and detachable therefrom.
摘要翻译： 有效地抑制各种试样的动态运动，同时容易地与各种类型，尺寸和形状的各种试样以及各种试样的检查方法相容。 在检查试样以检测试样的同时，在观察光轴附近与生物试样接触以抑制其运动的体内检查用稳定剂包括：构造成与生物试样接触的末端;以及活动部件， 使得尖端能够在与观察光轴相交的方向上移动。 尖端以可附接到可移动部件并且可从其拆卸的方式附接到可动部件。
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公开(公告)号：US07207937B2
公开(公告)日：2007-04-24
申请号：US11390368
申请日：2006-03-28
申请人： Chika Nakajima , Yoshihisa Tanikawa
发明人： Chika Nakajima , Yoshihisa Tanikawa
CPC分类号： G02B23/2476 , A61B5/0059
摘要： When examining a living organism exhibiting dynamic behavior such as pulsing, the dynamic behavior is suppressed and clear images are acquired. The invention provides an objective lens unit including a lens barrel for supporting optical components, wherein an end surface of the lens barrel is disposed farther towards the distal side than an optical component at the extreme distal end, and channel-shaped indented portions extending in the diametrical direction are formed in the end surface of the lens barrel.
摘要翻译： 当检查呈现动态行为的生物体如脉冲时，动态行为被抑制并且获得清晰的图像。 本发明提供了一种物镜单元，其包括用于支撑光学部件的透镜镜筒，其中透镜镜筒的端面远离远端侧的光学部件设置在远端侧，并且在该光学部件的远端延伸的通道形凹进部分 直径方向形成在镜筒的端面。
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公开(公告)号：US20060009682A1
公开(公告)日：2006-01-12
申请号：US11159204
申请日：2005-06-23
IPC分类号： A61B1/06
CPC分类号： A61B1/07 , A61B1/00172 , A61B1/0057
摘要： The invention provides an in-vivo examination apparatus that can examine a minute examination site in a living organism with a simple configuration. The invention provides an in-vivo examination apparatus comprising a light source; a flexible light-conveying member that transmits light from the light source to irradiate the light from an end face thereof onto an examination site and that receives return light returning from the examination site at the end face thereof to transmit the return light; a long thin insertion part in which the light-conveying member is disposed along the longitudinal direction thereof; and an optical detector that detects the return light from biological tissue, which is transmitted through the insertion part via the light-conveying member. The end face of the insertion part, where the end face of the light-conveying member is exposed, is configured so as to be cut at an angle with respect to the longitudinal direction to provide a pointed portion that can incise the biological tissue at the tip thereof.
摘要翻译： 本发明提供一种体内检查装置，其能够以简单的结构检查活体中的分检体位。 本发明提供了一种体内检查装置，其包括光源; 柔性光输送构件，其从所述光源透射光，以将光从其端面照射到检查部位，并且接收从其端面处的所述检查部位返回的返回光，以传送所述返回光; 长条状的薄插入部，沿着其长度方向配置有所述光输送部; 以及光检测器，其检测来自生物组织的返回光，所述返回光经由所述光输送构件透过所述插入部。 导光部的端面露出的插入部的端面被配置为相对于长度方向成一角度地切断，以提供能够将生物体组织切开的尖端部 其尖端。
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