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公开(公告)号：US06703378B1
公开(公告)日：2004-03-09
申请号：US10247452
申请日：2002-09-19
IPC分类号： A61K31695
CPC分类号： A61K31/695 , A61K9/0048 , A61K31/765
摘要： Fluorosilicone fluids useful as high-density fluid ocular tamponades and methods of producing, purifying and using the fluorosilicone fluids in an ocular surgical procedure for retinal treatment.
摘要翻译： 用作高密度流体眼压塞的氟硅酮流体，以及在用于视网膜处理的眼外科手术中制备，纯化和使用氟硅酮流体的方法。
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公开(公告)号：US06586548B2
公开(公告)日：2003-07-01
申请号：US10023557
申请日：2001-12-17
IPC分类号： C08F13008
CPC分类号： C08F230/08
摘要： The invention provides a biocompatible copolymer produced by polymerizing a mixture comprising at least one monomer selected from the group consisting of itaconates, (meth)acrylates, fumarates and styrenics, at least one ethylenically unsaturated organosiloxane monomer and at least one monomer comprising a POSS compound.
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公开(公告)号：US06440571B1
公开(公告)日：2002-08-27
申请号：US09315620
申请日：1999-05-20
IPC分类号： B32B2708
CPC分类号： C08J7/047 , A61L27/34 , C08J2383/04 , G02B1/043 , Y10T428/31663 , C08L83/10
摘要： The present invention is directed toward the surface treatment of silicone medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
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公开(公告)号：US5103812A
公开(公告)日：1992-04-14
申请号：US657426
申请日：1991-02-19
IPC分类号： A61L15/58 , A61F13/00 , A61F13/02 , A61L15/26 , A61L26/00 , C08L43/00 , C08L43/04 , C08L83/04 , C09D183/00 , C09D183/04 , C09J183/00 , C09J183/04
CPC分类号： C09D183/00 , A61F13/02 , A61L15/26 , A61L26/0019 , A61L26/0052 , A61F13/023 , A61F2013/0011 , A61F2013/00868 , A61F2013/0091 , Y10S128/21
摘要： Combinations of alkyl siloxy siloxane-containing polymers admixed with liquid polydimethylsiloxanes are excellent non-stinging, non-irritating liquid coating material for forming films which act as conformable bandages adhering to and protecting nails, skin and mucous membrane wounds from abrasion, contamination, and desiccation, while stopping pain from exposed nerve ends and allowing body fluid evaporation.
摘要翻译： 与液体聚二甲基硅氧烷混合的含烷基甲硅烷氧基硅氧烷的聚合物的组合是用于形成薄膜的非刺激性非刺激性液体涂料，其作为粘附并保护指甲，皮肤和粘膜伤口的磨损，污染和干燥的适形绷带 同时停止暴露的神经末梢的疼痛，并允许体液蒸发。
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公开(公告)号：US4321261A
公开(公告)日：1982-03-23
申请号：US51961
申请日：1979-06-25
IPC分类号： G02C13/00 , A61K9/00 , A61K31/74 , A61L12/08 , B29D11/00 , C08J3/03 , C08J7/04 , G02C7/04 , A61K31/72
CPC分类号： C08J3/03 , A61K31/74 , A61K9/0048 , A61L12/08 , B29D11/00865 , G02C7/04 , C08J2301/28
摘要： A contact lens solution is provided for wetting, soaking and lubricating of hard contact lenses, particularly those carrying an ionic charge. The solution contains an ionic polymer of cationic or anionic charge that interacts with an oppositely charged surface of a contact lens forming an interfacial polyelectrolyte complex. This polyelectrolyte complex provides increased, long lasting lens wettability leading to a cushioning and lubricating effect with the eyelid and the cornea.
摘要翻译： 提供隐形眼镜溶液用于润湿，浸泡和润滑硬性隐形眼镜，特别是携带离子电荷的隐形眼镜。 该溶液含有阳离子或阴离子电荷的离子聚合物，其与形成界面聚电解质络合物的隐形眼镜的带相反电荷的表面相互作用。 该聚电解质复合物提供增加的持久的透镜润湿性，导致眼睑和角膜的缓冲和润滑作用。
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公开(公告)号：US20130150451A1
公开(公告)日：2013-06-13
申请号：US13313880
申请日：2011-12-07
CPC分类号： A01N47/44 , A61K31/155 , Y02A50/473 , A01N31/02 , A01N37/12
摘要： An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.
摘要翻译： 描述了具有协同杀生物活性的抗微生物组合物，其包含至少一种抗微生物聚合双胍和至少一种抗微生物连位二醇，所述连位二醇包含至少一种单烷基二醇，单烷基甘油或单酰基甘油，以减少或消除生物膜群落。 这种协同相互作用在伤口治疗中是有效的，特别是对于慢性伤口，烧伤和战场引起的伤口以及用于消毒非生物表面。 抗微生物组合物也可以制备成粘稠溶液或凝胶。 抗微生物组合物可以加入到基质中并干燥，例如导管，或泡沫，或纤维伤口敷料，或在这种装置上作为粘性溶液或凝胶涂覆，以提供受控释放的抗微生物活性。
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公开(公告)号：US20120208974A1
公开(公告)日：2012-08-16
申请号：US13210038
申请日：2011-08-15
IPC分类号： C09J133/26 , C09J177/02
CPC分类号： C09J133/26 , C08F220/18 , C09J133/08 , C09J139/04 , C08F220/56
摘要： The present invention relates to amphiphilic pressure sensitive adhesives, specifically, pressure sensitive adhesives with amphiphilic copolymers which improve adhesion under moist environment. The amphiphilic copolymers comprise at least one hydrophobic acrylic monomer or oligomer and at least one hydrophilic or amphiphilic monomer or oligomer. The present invention also relates to the use of such adhesives in securing medical devices to human skin.
摘要翻译： 本发明涉及两亲压敏粘合剂，具体地说，涉及在潮湿环境下改善粘合性的两亲共聚物的压敏粘合剂。 两亲共聚物包含至少一种疏水性丙烯酸单体或低聚物和至少一种亲水或两亲性单体或低聚物。 本发明还涉及这种粘合剂在将医疗装置固定在人体皮肤上的用途。
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38.发明授权公开(公告)号：US08197841B2
公开(公告)日：2012-06-12
申请号：US11020541
申请日：2004-12-22
IPC分类号： A61F2/00
CPC分类号： G02B1/043
摘要： This invention describes the use of polymerizable surfactants as comonomers in forming ophthalmic devices such as contact lenses, intraocular lenses, corneal implants, etc.
摘要翻译： 本发明描述了可聚合表面活性剂作为共聚单体在形成眼科装置如隐形眼镜，人工晶状体，角膜植入物等中的用途。
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公开(公告)号：US07875661B2
公开(公告)日：2011-01-25
申请号：US11954090
申请日：2007-12-11
申请人： Joseph C. Salamone
发明人： Joseph C. Salamone
CPC分类号： A61L27/16 , A61L2430/16 , C08L33/24
摘要： An intraocular lens with an ordered polymer system contained within a lens capsule or a membrane in the lens capsule. The ordered polymer system includes at least one negatively charged copolymer comprising hydrophilic groups, anionic groups and hydrophobic groups, and at least one positively charged copolymer comprising hydrophilic groups, cationic groups and hydrophobic groups. The at least one negatively charged copolymer and the at least one positively charged copolymer are associatively arranged through non-covalent interactions in the lens capsule or the membrane.
摘要翻译： 具有有序聚合物系统的眼内透镜包含在晶状体囊或晶状体囊内的膜中。 有序的聚合物体系包括至少一种包含亲水基团，阴离子基团和疏水基团的带负电荷的共聚物，以及包含亲水基团，阳离子基团和疏水基团的至少一个带正电荷的共聚物。 所述至少一种带负电荷的共聚物和所述至少一种带正电荷的共聚物通过晶状体胶囊或膜中的非共价相互作用而相互排列。
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40.发明授权Silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups 有权用可聚合的阳离子亲水基团封端的含硅单体公开(公告)号：US07759408B2
公开(公告)日：2010-07-20
申请号：US11341209
申请日：2006-01-27
IPC分类号： G02B1/04 , C08F290/06
CPC分类号： G02B1/043 , A61L27/18 , C08F222/1006 , C08F230/08 , C08F290/06 , C08F290/061 , C08F290/068 , C08G77/388 , C08L51/085 , C08L101/02 , C08L83/04
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子单体。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含聚合的含有可聚合阳离子亲水基团的含硅单体。
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