公开(公告)号：US08208137B2

公开(公告)日：2012-06-26

申请号：US12696853

申请日：2010-01-29

Applicant: Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

Abstract translation: 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

公开(公告)号：US20120105841A1

公开(公告)日：2012-05-03

申请号：US12915148

申请日：2010-10-29

Applicant: Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

Inventor： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及 主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为 在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

公开(公告)号：US20120092660A1

公开(公告)日：2012-04-19

申请号：US12905891

申请日：2010-10-15

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

Abstract translation: 用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中 纳米手指以阵列排列在基板上。 该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层， 手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

公开(公告)号：US20110317160A1

公开(公告)日：2011-12-29

申请号：US13254897

申请日：2009-03-13

Applicant: Zhiyong Li ,  Min Hu

Inventor： Zhiyong Li ,  Min Hu

IPC: G01J3/44 ,  B29C35/02 ,  C23F1/02 ,  B29C70/00

CPC classification number: G01N21/554 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/658

Abstract: Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

Abstract translation: 本文公开了用于表面增强拉曼光谱的宽带结构。 结构的每个实施例由金属层和建立在金属层的至少一部分上的电介质层组成。 电介质层具有从电介质层的至少一部分到电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分，在电介质层上建立纳米结构，因此纳米结构被构造成表现出可变的等离子体共振。

公开(公告)号：US20110267609A1

公开(公告)日：2011-11-03

申请号：US12771824

申请日：2010-04-30

Applicant: Wei WU ,  Min Hu ,  Fung Suong Ou ,  Zhiyong Li

Inventor： Wei WU ,  Min Hu ,  Fung Suong Ou ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: An apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a reflective layer positioned above the substrate, a plurality of tapered nanowires disposed above the reflective layer, each of the plurality of tapered nanowires having a tapered end directed away from the reflective layer.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的设备包括位于衬底上方的反射层，设置在反射层上方的多个锥形纳米线，多个锥形纳米线中的每一个具有远离反射层的锥形端。

公开(公告)号：US20110188034A1

公开(公告)日：2011-08-04

申请号：US12697136

申请日：2010-01-29

Applicant: Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。 该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。 尖端被配置为吸附分析物并以振动频率振动。 该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。 纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。 该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。 该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

公开(公告)号：US20150065390A1

公开(公告)日：2015-03-05

申请号：US14394295

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

Inventor： Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

IPC: G01N21/65 ,  G01N35/00 ,  B01L3/00

CPC classification number: G01N21/658 ,  B01L3/5088 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/161 ,  G01N21/648 ,  G01N35/00009 ,  G01N2035/00019

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.

Abstract translation: 本文公开了集成传感器的示例。 集成传感器的示例包括形成在基板的表面上的基板和感测构件。 感测构件包括可折叠信号放大结构和围绕可折叠信号放大结构的区域，其使得能够将暴露于其的液滴自动定位到可折叠信号放大结构。

公开(公告)号：US08810788B2

公开(公告)日：2014-08-19

申请号：US13254897

申请日：2009-03-13

Applicant: Zhiyong Li ,  Min Hu

Inventor： Zhiyong Li ,  Min Hu

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/55

CPC classification number: G01N21/554 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/658

Abstract: Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

Abstract translation: 本文公开了用于表面增强拉曼光谱的宽带结构。 结构的每个实施例由金属层和建立在金属层的至少一部分上的电介质层组成。 电介质层具有从电介质层的至少一部分到电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分，在电介质层上建立纳米结构，因此纳米结构被构造成表现出可变的等离子体共振。

公开(公告)号：US20140199778A1

公开(公告)日：2014-07-17

申请号：US14239330

申请日：2011-09-30

Applicant: Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

Inventor： Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

IPC: G01N31/22

CPC classification number: G01N31/22 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/141 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0819 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N2201/0227 ,  G01N2201/023 ,  Y10T436/25

Abstract: Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.

Abstract translation: 公开了检测物质的装置和制造这种装置的方法。 用于检测物质的示例性装置包括限定外部可触及室的壳体和用于封闭室的至少一部分的密封件。 该示例性装置还包括基底，其包括位于腔室内的纳米颗粒。 纳米颗粒暴露于物质时与物质反应。 该示例性装置还包括室内的非分析溶液以保护纳米颗粒免于过早曝光。

公开(公告)号：US20130107250A1

公开(公告)日：2013-05-02

申请号：US13282606

申请日：2011-10-27

Applicant: Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

Inventor： Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

IPC: G01N21/01

CPC classification number: B82Y40/00 ,  B82Y15/00 ,  G01N21/554 ,  G01N21/658

Abstract: A structure for molecular analysis is disclosed. The structure includes a nanostructure and a nanoparticle attached to the nanostructure, wherein the nanostructure is free-standing and wherein the nanoparticle, the nanostructure or both the nanoparticle and the nanostructure are coated with a metal coating; or a plurality of nanoparticles, wherein the plurality of nanoparticles is free-standing and wherein each nanoparticle in the plurality is coated with a metal coating and is separated from one other nanoparticle or two other nanoparticles by a distance of 0.5 nm to 1 nm. A method for preparing the structure for molecular analysis is also disclosed.

Abstract translation: 公开了一种用于分子分析的结构。 该结构包括纳米结构和连接到纳米结构的纳米颗粒，其中纳米结构是独立的，并且其中纳米颗粒，纳米结构或纳米颗粒和纳米结构二者都涂覆有金属涂层; 或多个纳米颗粒，其中所述多个纳米颗粒是独立的，并且其中所述多个纳米颗粒中的每个纳米颗粒涂覆有金属涂层，并且与另外一个纳米颗粒或两个其它纳米颗粒分开0.5nm至1nm的距离。 还公开了用于分子分析结构的制备方法。