中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

95 records (took 0.032 seconds)

    Method of treating a disease or condition characterised by aberrant epithelial cell proliferation
    31.
    发明授权
    Method of treating a disease or condition characterised by aberrant epithelial cell proliferation 有权
    治疗以异常上皮细胞增殖为特征的疾病或病症的方法

    公开(公告)号：US08933027B2

    公开(公告)日：2015-01-13

    申请号：US14032848

    申请日：2013-09-20

    Applicant: Queensland University of Technology

    Inventor： Zee Upton ,  Jennifer Ann Kricker

    IPC: A61K38/30 ,  A61K38/39 ,  A61P35/00 ,  C07K14/65 ,  A61K47/48 ,  A61K38/17 ,  C07K14/71 ,  C07K14/78

    CPC classification number: A61K47/48246 ,  A61K38/1709 ,  A61K38/30 ,  A61K38/39 ,  C07K14/71 ,  C07K14/78 ,  A61K2300/00

    Abstract: A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor I (IGF-I); an insulin-like growth factor binding protein (IGFBP) selected from IGFBP-3 and IGFBP-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal. The agent is selected from the group consisting a polypeptide that is distinguished from IGF-II by substitution of at least one amino acid residue, wherein the polypeptide disrupts the isolated protein complex.

    Abstract translation: 提供了一种治疗以异常上皮细胞增殖和/或迁移为特征的疾病或病症的方法。 该方法的一个步骤可以包括向哺乳动物施用破坏分离的蛋白质复合物的试剂，包括：胰岛素样生长因子I（IGF-I）; 选自IGFBP-3和IGFBP-5的胰岛素样生长因子结合蛋白（IGFBP）; 和玻连蛋白; 或其防止分离的蛋白质复合物的形成，从而治疗哺乳动物的疾病或病症。 所述试剂选自通过至少一个氨基酸残基的取代与IGF-II区分的多肽，其中多肽破坏分离的蛋白质复合物。

    PURINE-TARGETED DIAGNOSIS AND THERAPY OF WOUNDS
    32.
    发明申请
    PURINE-TARGETED DIAGNOSIS AND THERAPY OF WOUNDS 审中-公开
    目标诊断和治疗疗法

    公开(公告)号：US20120219536A1

    公开(公告)日：2012-08-30

    申请号：US13392340

    申请日：2010-08-13

    Applicant: Melissa Laura Fernandez ,  Gary Keith Shooter

    Inventor： Melissa Laura Fernandez ,  Gary Keith Shooter

    IPC: A61K38/44 ,  A61K31/7088 ,  C12Q1/26 ,  G01N33/573 ,  A61F13/00 ,  G01N33/50 ,  A61K31/519 ,  A61K31/426 ,  A61K31/352 ,  A61P17/02 ,  A61K38/02 ,  G01N21/76

    CPC classification number: A61K31/7076 ,  A61K31/352 ,  A61K31/427 ,  Y10T436/147777 ,  Y10T436/148888

    Abstract: Methods of treating a wound, an ulcer and/or a burn responsive to inhibition of xanthine oxidoreductase to thereby reduce uric acid in an animal are provided wherein the methods include topical administration of a therapeutic agent effective for treatment of the wound, the ulcer and/or the burn wherein the therapeutic agent inhibits xanthine oxidoreductase to thereby reduce uric acid in the wound, ulcer and/or burn. Also provided are methods and kits for determining the severity of a wound, a burn and/or an ulcer including the step of detecting one or more of (i) a level of uric acid; (ii) a level of one or more uric acid precursors; and (iii) a presence, or absence of or level of xanthine oxidoreductase.

    Abstract translation: 提供了治疗对黄嘌呤氧化还原酶抑制作用的伤口，溃疡和/或烧伤的治疗方法，其中所述方法包括局部施用有效治疗伤口，溃疡和/ 或烧伤，其中治疗剂抑制黄嘌呤氧化还原酶，从而减少伤口，溃疡和/或烧伤中的尿酸。 还提供了用于确定伤口，烧伤和/或溃疡的严重性的方法和试剂盒，包括检测（i）尿酸水平中的一种或多种的步骤; （ii）一种或多种尿酸前体的水平; 和（iii）黄嘌呤氧化还原酶的存在或不存在或水平。

    Protein expression
    33.
    发明授权
    Protein expression 失效
    蛋白质表达

    公开(公告)号：US07585936B2

    公开(公告)日：2009-09-08

    申请号：US10576982

    申请日：2004-10-22

    Applicant: Mark S. Turner ,  Philip M. Giffard

    Inventor： Mark S. Turner ,  Philip M. Giffard

    IPC: C12P21/06 ,  C12P21/04

    CPC classification number: C07K14/195 ,  C07K14/315 ,  C07K14/335 ,  C07K2319/00

    Abstract: The invention provides a peptide having at least about 75% amino acid homology with the sequence shown in SEQ ID No: 2. The peptide of the invention also can include an amino acid homology with the sequence shown in SEQ ID No: 2 corresponding to at least about 80%, at least about 85%, at least about 90% or can include the amino acid sequence shown in SEQ ID No: 2. The peptide of the invention can further include an amino acid sequence selected from the sequences shown in SEQ ID Nos: 1, 3 or 4-6.

    Abstract translation: 本发明提供了与SEQ ID No：2所示序列具有至少约75％氨基酸同源性的肽。本发明的肽还可以包括与SEQ ID No：2所示的序列的氨基酸同源性，其对应于 至少约80％，至少约85％，至少约90％或可以包括SEQ ID No：2所示的氨基酸序列。本发明的肽还可包含选自SEQ ID NO：2所示序列的氨基酸序列 身份证号：1,3或4-6。

    Dynamic match lattice spotting for indexing speech content
    34.
    发明申请
    Dynamic match lattice spotting for indexing speech content 审中-公开
    用于索引语音内容的动态匹配格点

    公开(公告)号：US20070179784A1

    公开(公告)日：2007-08-02

    申请号：US11377327

    申请日：2006-03-16

    Applicant: Albert Joseph Thambiratnam ,  Subramanian Sridharan

    Inventor： Albert Joseph Thambiratnam ,  Subramanian Sridharan

    IPC: G10L15/28

    CPC classification number: G10L15/26 ,  G10L2015/025

    Abstract: A system for indexing and searching speech content, the system includes two distinct stages, a speech indexing stage (100) and a speech retrieval stage (200). A phone lattice (103) is generated by passing speech content (101) through a speech recogniser (102). The resulting phone lattice is then processed to produce a set of observed sequences Q=(Θ,i) where Θ are the set of observed phone sequences for each node i in the phone lattice. During the retrieval stage (200), a user first inputs a target word (205) into the system, which is then reduced to a target phone sequence P=(p1, p2, . . . , pN) (207). The system then compares target sequence P with the set of observed sequences Q (208), suitably by scoring each observed sequence against the target sequence using a Minimum Edit Distance (MED) calculation to produce a set of matching sequences R (209).

    Abstract translation: 一种用于索引和搜索语音内容的系统，该系统包括两个不同的阶段，语音索引阶段（100）和语音检索阶段（200）。 通过语音识别器（102）传递语音内容（101）来生成电话格（103）。 所得到的电话格子然后被处理以产生一组观察到的序列Q =（Theta，i），其中Theta是电话格中每个节点i的观察到的电话序列的集合。 在检索阶段（200）期间，用户首先将目标字（205）输入到系统中，然后将目标字（205）减少到目标电话序列P =（p1> 1，p2 < / SUB>，...，p N N N）（207）。 然后，系统通过使用最小编辑距离（MED）计算来针对目标序列评估每个观察到的序列以产生一组匹配序列R（209），将目标序列P与观察序列集合Q（208）进行比较。

    Novel diagnostic agents of chronic or persistent chlamydial diseases and uses thereof
    35.
    发明申请
    Novel diagnostic agents of chronic or persistent chlamydial diseases and uses thereof 审中-公开
    慢性或持续性衣原体疾病的新型诊断剂及其用途

    公开(公告)号：US20040002440A1

    公开(公告)日：2004-01-01

    申请号：US10369435

    申请日：2003-02-19

    Applicant: Queensland University of Technology

    Inventor： Peter Timms ,  Sarah Anne Mathews

    IPC: A61K038/16 ,  A61K048/00 ,  G01N033/554 ,  G01N033/569 ,  C12Q001/68

    CPC classification number: C07K14/295 ,  A61K39/00 ,  G01N33/56927

    Abstract: The present invention discloses compositions and methods for detecting organisms of the Chlamydiaceae family, including species of Chlamydia and Chlamyclophila, in the persistent phase of their developmental cycle and for the diagnosis of chronic or persistent infections caused by such organisms. The present invention also discloses methods for screening agents that are useful inter alia for modulating a gene whose expression is altered in the persistent phase of the chiamydial developmental cycle or for modulating the level and/or functional activity of an expression product of that gene. Also disclosed are methods and compositions for the treatment and/or prophylaxis of infections, including chronic infections, caused by chamydial organisms using the aforesaid modulatory agents and optionally agents that are effective in modulating the expression of a gene associated with the lytic phase of said developmental cycle or in modulating the level and/or functional activity of an expression product of that gene. The invention also discloses methods and compositions for the treatment and/or prophylaxis of such infections using a first immunopotentiating agent that elicits the production of elements that are immuno-interactive with an antigen associated with the persistent phase of the chlamydial developmental cycle and a second immunopotentiating agent that elicits the production of elements that are immuno-interactive with an antigen associated with the lytic phase of said developmental cycle.

    Abstract translation: 本发明公开了用于检测衣原体科（Chlamydiaceae）家族的生物体的组合物和方法，包括衣原体和沙眼衣原体的种类，其发育周期的持续期以及用于诊断由这些生物引起的慢性或持续性感染。 本发明还公开了用于筛选试剂的方法，所述筛选试剂特别用于调节其在chiamydial发育周期的持续期中表达改变的基因或用于调节该基因的表达产物的水平和/或功能活性。 还公开了用于使用上述调节剂和任选的有效调节与所述发育的溶解期相关基因表达的治疗和/或预防感染的方法和组合物，包括慢性感染 循环或调节该基因的表达产物的水平和/或功能活性。 本发明还公开了使用第一免疫增强剂治疗和/或预防这种感染的方法和组合物，所述第一免疫增强剂引发与与衣原体发育周期的持续期相关的抗原免疫相互作用的元件，以及第二免疫增强剂 引发与与所述发育周期的溶解期相关的抗原免疫相互作用的元件的产生。

    Test sampling apparatus
    37.
    发明授权
    Test sampling apparatus 失效
    测试取样仪

    公开(公告)号：US5510081A

    公开(公告)日：1996-04-23

    申请号：US315845

    申请日：1994-09-30

    Applicant: John Edwards ,  David Nuske

    Inventor： John Edwards ,  David Nuske

    IPC: B23Q7/04 ,  B26D7/18 ,  B26F1/02 ,  G01N1/28 ,  G01N35/10

    CPC classification number: G01N35/10 ,  B23Q7/043 ,  B26D7/18 ,  B26F1/02 ,  G01N2001/288

    Abstract: A distribution apparatus for transporting an article struck from sheet metal is disclosed, which includes a receiving head having a recess for receiving the article struck from the sheet. The recess includes a resilient interference feature extending inwardly beyond the boundary of the article to be received. Transporting apparatus is further provided for transporting the receiving head to a selected destination and, finally, a discharging element is included for discharging the article from the receiving head at the selected destination.

    Abstract translation: 公开了一种用于输送从金属板材冲击的物品的分配装置，其包括具有用于接收从该片材冲击的物品的凹部的接收头。 该凹部包括向内延伸超过待接收物品的边界的弹性干涉特征。 进一步提供运送装置用于将接收头运送到所选择的目的地，并且最后包括放电元件，用于在所选择的目的地从接收头排出物品。

Patent Agency Ranking