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31.发明授权Methods for processing biological materials using peelable and resealable devices 失效使用可剥离和可重新密封的装置处理生物材料的方法公开(公告)号：US07351575B2
公开(公告)日：2008-04-01
申请号：US10206590
申请日：2002-07-29
Applicant: David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
Inventor： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
CPC classification number: G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12M23/34 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US07244598B2
公开(公告)日：2007-07-17
申请号：US09928367
申请日：2001-08-14
Applicant: David Duffy
Inventor： David Duffy
CPC classification number: C40B30/04 , B01J19/0046 , B01J2219/00382 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/0072 , B01J2219/00725 , B82Y30/00 , B82Y40/00 , C07B2200/11 , C40B40/10 , C40B60/14 , G01N33/54306 , G01N33/6845
Abstract: Array systems that facilitate the simultaneous monitoring of many interactions between biological molecules and the analysis of cellular protein interactions with high throughput. The present invention provides methods and arrays for analyzing biochemical pathways by forming an array of immobilized biomolecules; exposing the array to biomolecules in solution; and detecting modification of the immobilized biomolecules, modification of the biomolecules in solution, and/or binding of biomolecules in solution to immobilized biomolecules.
Abstract translation: 阵列系统有助于同时监测生物分子之间的许多相互作用和高通量的细胞蛋白质相互作用分析。 本发明提供了通过形成固定的生物分子阵列分析生物化学途径的方法和阵列; 使阵列暴露于溶液中的生物分子; 并检测固定的生物分子的修饰，溶液中生物分子的修饰和/或溶液中生物分子与固定的生物分子的结合。
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33.发明授权Soft lithographic process for fabricating integrated ITO electrode-liquid crystal alignment layers 有权用于制造集成ITO电极 - 液晶取向层的软光刻工艺公开(公告)号：US07128631B2
公开(公告)日：2006-10-31
申请号：US10714190
申请日：2003-11-14
Applicant: Christopher H. McCoy , John T. Chen , David R. Beaulieu
Inventor： Christopher H. McCoy , John T. Chen , David R. Beaulieu
CPC classification number: B82Y30/00 , G02F1/133512 , G02F1/133516 , G02F1/13439 , G02F1/1362
Abstract: A system and method are described for self-aligning electrodes for color filters of passive matrix displays.
Abstract translation: 描述了用于无源矩阵显示器的彩色滤光片的自对准电极的系统和方法。
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公开(公告)号：US07123764B2
公开(公告)日：2006-10-17
申请号：US10097302
申请日：2002-03-15
Applicant: Gregory L. Kirk , Matthew Brown , Emanuele Ostuni , Enoch Kim , Bernardo D. Aumond , Olivier Schueller , Paul Sweetnam , Brian Benoit
Inventor： Gregory L. Kirk , Matthew Brown , Emanuele Ostuni , Enoch Kim , Bernardo D. Aumond , Olivier Schueller , Paul Sweetnam , Brian Benoit
IPC: G06K9/00
CPC classification number: B01L3/5085 , B01L2200/12 , B01L2300/0636 , B01L2300/0887 , G06T7/70 , G06T2207/30072
Abstract: An image processing method for use in analyzing image data of a cellular migration assay. The method includes defining a major axis within the image data that is perpendicular to an orientation of channels in the image data, determining an aggregate light intensity within the image data along the major axis, and identifying locations of channels within the image data from the projection.
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公开(公告)号：US07033821B2
公开(公告)日：2006-04-25
申请号：US10206111
申请日：2002-07-29
Applicant: Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
Inventor： Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
IPC: C12M1/34
CPC classification number: G06K9/0014 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5085 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B82Y30/00 , C12M23/12 , C12M25/06 , C12M41/46 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G06T7/0012 , G06T7/70 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072
Abstract: The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.
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Patent Agency Ranking
公开(公告)号：US07033819B2
公开(公告)日：2006-04-25
申请号：US10206196
申请日：2002-07-29
Applicant: Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
Inventor： Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
IPC: C12M1/36
CPC classification number: G01N33/5029 , B01D2325/08 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C12M23/12 , C12M25/06 , C12M41/46 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N33/54366 , G01N2015/1497 , G06K9/00127 , G06K9/0014 , G06T7/0012 , G06T7/70 , G06T2207/30072
Abstract: The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.
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37.发明授权Methods of arraying biological materials using peelable and resealable devices 失效使用可剥离和可再密封装置排列生物材料的方法公开(公告)号：US07001740B2
公开(公告)日：2006-02-21
申请号：US10206075
申请日：2002-07-29
Applicant: David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
Inventor： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
CPC classification number: B82Y30/00 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G06T7/0012 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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38.发明申请Soft lithographic process for fabricating integrated ITO electrode-liquid crystal alignment layers 有权用于制造集成ITO电极 - 液晶取向层的软光刻工艺公开(公告)号：US20040266307A1
公开(公告)日：2004-12-30
申请号：US10714190
申请日：2003-11-14
Applicant: Surface Logix, Inc.
Inventor： Christopher H. McCoy , John T. Chen , David R. Beaulieu
IPC: H01J009/00 , H01J009/24
CPC classification number: B82Y30/00 , G02F1/133512 , G02F1/133516 , G02F1/13439 , G02F1/1362
Abstract: A system and method are described for self-aligning electrodes for color filters of passive matrix displays.
Abstract translation: 描述了用于无源矩阵显示器的彩色滤光片的自对准电极的系统和方法。
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公开(公告)号：US20130096114A1
公开(公告)日：2013-04-18
申请号：US13708420
申请日：2012-12-07
Applicant: SURFACE LOGIX, INC.
Inventor： Stewart Campbell , David Duffy , Michael Grogan , Steven Kates , Emanuele Ostuni , Olivier Schueller , Paul Sweetnam
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.
Abstract translation: 提供具有改善的非特异性结合特征和药代动力学性质的式A化合物：或其药学上可接受的盐，立体异构体或其水合物。
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40.发明申请Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds 审中-公开制备包含功能性残基或组的药代动力学改进的化合物的方法以及包含所述化合物的药物组合物公开(公告)号：US20110172422A1
公开(公告)日：2011-07-14
申请号：US11884811
申请日：2006-02-21
Applicant: Stewart Campbell , David Duffy , Michael Grogan , Steven Kates , Emanuele Ostuni , Olivier Schueller , Paul Sweetnam
Inventor： Stewart Campbell , David Duffy , Michael Grogan , Steven Kates , Emanuele Ostuni , Olivier Schueller , Paul Sweetnam
IPC: C07D487/04
CPC classification number: A61K31/53
Abstract: The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.
Abstract translation: 本发明涉及通过将至少一个功能单元或基团连接到化合物上来调节化合物的药代动力学和/或药效学性质的方法，从而改善其非特异性结合特征和/或药代动力学性质。 提供包含至少一个功能性残基的化合物，以及包含所述化合物的药物组合物。
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