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1.发明授权公开(公告)号：US06803205B2
公开(公告)日：2004-10-12
申请号：US10206534
申请日：2002-07-29
Applicant: David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
Inventor： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
IPC: C12Q148
CPC classification number: G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US06699665B1
公开(公告)日：2004-03-02
申请号：US09709776
申请日：2000-11-08
Applicant: Enoch Kim , David Duffy
Inventor： Enoch Kim , David Duffy
IPC: C12Q168
CPC classification number: B01L3/5085 , B01D2325/08 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B82Y30/00 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N33/54366 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/30072 , Y10S435/81
Abstract: A multiple level micro-array system for integrating micro-arrays of biomolecules, including biological, chemical and biochemical elements. The multiple level micro-arrays are formed using soft lithography techniques and elastomeric membranes to shield or pattern various portions of a suitable substrate with biomolecules. Additional levels are formed using membranes with various through holes which either isolate, stratify or shield the patterned biomolecules from subsequent patterning or addition of an assay solution.
Abstract translation: 用于整合微生物分子微阵列的多级微阵列系统，包括生物，化学和生物化学元素。 使用软光刻技术和弹性膜形成多层微阵列，以用生物分子屏蔽或图案化合适的底物的各个部分。 使用具有各种通孔的膜形成附加水平，其分离，分层或屏蔽图案化的生物分子，从而随后图案化或添加测定溶液。
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公开(公告)号：US20150196132A1
公开(公告)日：2015-07-16
申请号：US14414996
申请日：2012-07-20
Applicant: David Duffy , Michael Lynch , Duncan Bain
Inventor： David Duffy , Michael Lynch , Duncan Bain
CPC classification number: A47C31/123 , G01M99/001 , G01N2203/0085
Abstract: The present invention is directed to a mattress measurement tool (100). The mattress measurement tool (100) comprises mattress-engaging pads (110A, 110B), where the mattress-engaging pads (110A, 110B) are located at each free end of the substantially horizontal cross-member (108). The mattress measurement tool (100) further comprises a distance measuring device (118) for measuring a conformity characteristic of the mattress. The mattress measurement tool (100) is capable of measuring support, conformity and rebound of the mattress.
Abstract translation: 本发明涉及一种床垫测量工具（100）。 床垫测量工具（100）包括床垫接合垫（110A，110B），其中床垫接合垫（110A，110B）位于基本上水平的横向构件（108）的每个自由端。 床垫测量工具（100）还包括用于测量床垫的一致性的测距装置（118）。 床垫测量工具（100）能够测量床垫的支撑，一致性和反弹。
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4.发明申请公开(公告)号：US20090325262A1
公开(公告)日：2009-12-31
申请号：US12081650
申请日：2008-04-18
Applicant: Christian Hodneland , Stewart Campbell , David Duffy , Melina Agosto , Evelyn Wang
Inventor： Christian Hodneland , Stewart Campbell , David Duffy , Melina Agosto , Evelyn Wang
CPC classification number: B82Y30/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00686 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00727 , B82Y40/00 , C07B2200/11 , C07K1/1077 , C12N9/18 , C12N11/14 , C40B40/00 , G01N33/54353
Abstract: The present invention provides an article for immobilizing functional organic biomolecules through a covalent bond to a thiolate monolayer on a coinage metal surface. Also provided are methods for making the article and method for the immobilization of functional organic biomolecules on the article. The thiolate monolayer contains two moieties, one having an inert group that is resistant to reacting with biomolecules and one having a covalent bond forming group that reacts with the functional organic biomolecule to covalently immobilize it on the monolayer.
Abstract translation: 本发明提供了通过共价键将功能性有机生物分子固定在造币金属表面上的硫醇盐单层的制品。 还提供了制备用于将功能性有机生物分子固定在制品上的制品和方法的方法。 硫醇盐单层包含两个部分，一个具有与生物分子反应的惰性基团，一个具有共价键形成基团的官能团与功能性有机生物分子反应以将其共价固定在单层上。
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5.发明申请公开(公告)号：US20050133741A1
公开(公告)日：2005-06-23
申请号：US10824331
申请日：2004-04-14
Applicant: Olivier Schueller , David Duffy , John Rogers , Scott Brittain , George Whitesides
Inventor： Olivier Schueller , David Duffy , John Rogers , Scott Brittain , George Whitesides
CPC classification number: B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L2200/0689 , B01L2300/0654 , B01L2300/0861 , B01L2300/123 , B01L2400/0418 , G01N21/45 , G01N21/4788 , Y10T428/24562 , Y10T428/2457 , Y10T428/24744 , Y10T428/31663
Abstract: A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.
Abstract translation: 提供了一种用于将样品的分离部分定位在样品室的细长平行通道中并用于在室中照射样品以产生样品和室的折射率不同的衍射图案的系统。 该系统还可以测量室内样品对电磁辐射的吸收，并可以通过样品的衍射测量同时测量吸收。
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Patent Agency Ranking
公开(公告)号：US07371563B2
公开(公告)日：2008-05-13
申请号：US10206074
申请日：2002-07-29
Applicant: David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Amber Agosto , Enoch Kim
Inventor： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Amber Agosto , Enoch Kim
CPC classification number: G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/30072 , Y10T428/24281 , Y10T428/24289 , Y10T428/24306
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US06967074B2
公开(公告)日：2005-11-22
申请号：US10206081
申请日：2002-07-29
Applicant: David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
Inventor： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
CPC classification number: G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates thc performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦的表面，其有利于在和/或 检测固定化材料。
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公开(公告)号：US20050158880A1
公开(公告)日：2005-07-21
申请号：US11060631
申请日：2005-02-17
Applicant: Emanuele Ostuni , Ravindra Kane , George Whitesides , Rebecca Jackman , David Duffy
Inventor： Emanuele Ostuni , Ravindra Kane , George Whitesides , Rebecca Jackman , David Duffy
CPC classification number: B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00427 , B01J2219/0043 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00659 , B01J2219/00743 , B82Y5/00 , C12M21/08 , C12M25/04 , C12M25/08 , C12M33/00 , C12N11/06 , C40B60/14
Abstract: The present invention provides a masking system for selectively applying cells to predetermined regions of a surface. A mask is positioned adjacent to a surface to cover some portions of the surface while allowing other portions of the surface to remain uncovered. Cells then are applied to uncovered portions of the surface and the mask removed. Alternatively, a cell-adhesion promoter is applied to uncovered portions of the surface, and then cells are applied to the surface before or after removal of the mask from the surface. The masking system can be pre-coated, at least on those surfaces which will come into contact with cells, with a cell-adhesion inhibitor to resist absorption of cells and thereby avoid cell damage when the mask is removed (if cells are deposited prior to removal of the mask). A polymeric elastomeric mask that comes into cohesive-conformal contact with a surface to be patterned can be used.
Abstract translation: 本发明提供了一种用于选择性地将电池施加到表面的预定区域的掩模系统。 掩模邻近表面定位以覆盖表面的一些部分，同时允许表面的其它部分保持未被覆盖。 然后将细胞施加到表面的未覆盖部分并除去掩模。 或者，将细胞粘附促进剂施加到表面的未覆盖部分，然后在从表面除去掩模之前或之后将细胞施加到表面。 掩蔽系统可以至少在与细胞接触的那些表面上预先涂覆有细胞粘附抑制剂以抵抗细胞的吸收，从而在去除掩模时避免细胞损伤（如果细胞在 去除面膜）。 可以使用与要图案化的表面粘合保形接触的聚合物弹性体掩模。
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公开(公告)号：US07439056B2
公开(公告)日：2008-10-21
申请号：US10206080
申请日：2002-07-29
Applicant: David Duffy , Gregory Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto , Enoch Kim
Inventor： David Duffy , Gregory Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto , Enoch Kim
CPC classification number: G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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10.发明授权Methods for processing biological materials using peelable and resealable devices 失效使用可剥离和可重新密封的装置处理生物材料的方法公开(公告)号：US07351575B2
公开(公告)日：2008-04-01
申请号：US10206590
申请日：2002-07-29
Applicant: David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
Inventor： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto
CPC classification number: G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12M23/34 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Abstract translation: 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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