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    SYSTEM AND METHOD FOR PRECISION DOSING FOR ELECTRICAL STIMULATION OF THE BRAIN
    34.
    发明公开
    SYSTEM AND METHOD FOR PRECISION DOSING FOR ELECTRICAL STIMULATION OF THE BRAIN 审中-公开

    公开(公告)号：US20230293899A1

    公开(公告)日：2023-09-21

    申请号：US18018734

    申请日：2021-07-28

    申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

    发明人： Adam J. WOODS ,  Alejandro ALBIZU ,  Ruogu FANG ,  Aprinda INDAHLASTARI

    IPC分类号： A61N1/40

    CPC分类号： A61N1/40

    摘要： A method is provided for precision dosing of electrical stimulation of the brain. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of an electro-stimulation device including a plurality of electrodes positioned on a head of a subject. The method also includes obtaining measurements that indicate a tissue type at each voxel inside the head of the subject based on an imaging device. The method also includes determining, with a processor, a value of one or more parameters of the electro-stimulation device based on the tissue type measurements at each voxel such that the electro-stimulation device is configured to generate a value of one or more parameters of an electric field at each voxel inside the head of the subject to improve the treatment outcome of the subject.

    LACTOBACILLUS FORMULATIONS WITH IMPROVED STABILITY AND EFFICACY
    35.
    发明公开
    LACTOBACILLUS FORMULATIONS WITH IMPROVED STABILITY AND EFFICACY 审中-公开

    公开(公告)号：US20230293607A1

    公开(公告)日：2023-09-21

    申请号：US18120670

    申请日：2023-03-13

    申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

    发明人： Graciela Liliana LORCA ,  Claudio F. GONZALEZ

    IPC分类号： A61K35/747 ,  A61K9/00 ,  A61K9/19 ,  A61K47/10 ,  A61K47/46

    CPC分类号： A61K35/747 ,  A61K9/0053 ,  A61K9/19 ,  A61K47/10 ,  A61K47/46

    摘要： A composition is provided herein directed to a mixture of one or more Lactobacillus sp. and a phenolic compound. In a specific embodiment, disclosed is a Lactobacillus/phenol mixture that has been lyophilized to form a Lactobacillus/phenol lyophilized mixture. The Lactobacillus/phenol mixture of Lactobacillus/phenol lyophilized mixture may be packaged in a capsule, emulsion, or tablet such that the Lactobacillus are protected in a gastrointestinal tract for transport to an intestine of a subject. In another embodiment, a method for treating indigestion, abdominal pain or cephalic syndrome in a subject including orally administering to the subject a composition comprising an effective amount of Lactobacillus/phenol mixture or lyophilized mixture. In still a further embodiment, of improving immune function in a subject, comprising administering to the subject, the composition comprising an effective amount of Lactobacillus/phenol mixture or lyophilized mixture.

    ENHANCING AAV-MEDIATED DELIVERY AND TRANSDUCTION WITH POLYVINYL ALCOHOL
    40.
    发明公开
    ENHANCING AAV-MEDIATED DELIVERY AND TRANSDUCTION WITH POLYVINYL ALCOHOL 审中-公开

    公开(公告)号：US20230233708A1

    公开(公告)日：2023-07-27

    申请号：US17918887

    申请日：2021-04-13

    申请人： University of Florida Research Foundation, Incorporated

    发明人： Keyun Qing ,  Arun Srivastava

    IPC分类号： A61K48/00

    CPC分类号： A61K48/0041 ,  A61K48/0058

    摘要： Disclosed herein are novel methods for administration of rAAV particles having enhanced transduction properties, comprising the pre-incubation and co-administration of AAV capsids and polyvinyl alcohol (PVA). The disclosed methods of rAAV particle administration have improved efficiency in transducing mammalian liver and hematopoetic cells in vivo. The disclosed methods are suitable for use with a variety of AAV capsid serotypes and presudotypes and improve vector potency, thus lowering the concentration of rAAV particle required to achieve the desired effect. Further disclosed herein are buffers for storage and manufacturing of rAAV particles comprising PVA.