公开(公告)号：US20230414608A1

公开(公告)日：2023-12-28

申请号：US18343285

申请日：2023-06-28

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Christopher Fisher ,  Terri G. Edwards ,  David C. Bloom

IPC: A61K31/4965 ,  A61P31/22 ,  A61K31/439 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/5517 ,  A61K31/505 ,  A61K31/4745 ,  A61K31/5355 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/36

CPC classification number: A61K31/4965 ,  A61P31/22 ,  A61K31/439 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/36 ,  A61K31/505 ,  A61K31/4745 ,  A61K31/5355 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/5517

Abstract: The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating or preventing herpesvirus infection and/or herpesvirus-associated diseases and disorders.

公开(公告)号：US20230414457A1

公开(公告)日：2023-12-28

申请号：US18253616

申请日：2021-11-22

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Ge QU ,  Bruce D. SPIESS

IPC: A61J13/00 ,  A61J11/00

CPC classification number: A61J13/00 ,  A61J11/0005

Abstract: System, devices, and methods relating to breastfeeding assistance systems, nipple shields, supplemental nursing systems, and use thereof are described herein. Various embodiments provide a nipple shield to be placed on a breast and cover a nipple of a nursing woman. In various embodiments, the nipple shield comprises micro-structures configured to adhere to a breast. In various embodiments, the micro-structures comprise angled fibers. In various embodiments, the nipple shield comprises a Supplementary Nursing System (SNS) conduction system configured to fluidly connect an SNS to the nipple shield. In various embodiments, the SNS conduction system comprises a port and microtubes.

公开(公告)号：US20230385493A1

公开(公告)日：2023-11-30

申请号：US18325649

申请日：2023-05-30

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Sandip RAY ,  Maneesh MERUGU ,  Dipal HALDER

IPC: G06F30/327 ,  G06F30/3323 ,  H03K19/17728

CPC classification number: G06F30/327 ,  G06F30/3323 ,  H03K19/17728

Abstract: Various embodiments of the present disclosure provide for redacting Network-on-Chip (NoC) functionality in a System-on-Chip (SoC). In one example, an embodiment provides for receiving a Register Transfer Level (RTL) source code that models a design for an SoC via a hardware description language, converting one or more routing tables related to the RTL source code with one or more configurable logic tables, replacing one or more connections related to the RTL source code with one or more programmable multiplexers, generating a transformed RTL source code for the SoC based on the one or more configurable logic tables and the one or more programmable multiplexers, and/or providing an attack-resistant obfuscated SoC based on the transformed RTL source code.

公开(公告)号：US20230381104A1

公开(公告)日：2023-11-30

申请号：US18026389

申请日：2021-09-15

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Christian Jobin ,  Thomas D. Schmittgen ,  Rachel Newsome

IPC: A61K9/127 ,  C12N15/113 ,  C12N15/88 ,  C12N5/09 ,  A61K31/7105 ,  A61P31/04

CPC classification number: A61K9/127 ,  C12N15/113 ,  C12N15/88 ,  C12N5/0693 ,  A61K31/7105 ,  A61P31/04 ,  C12N2310/14 ,  C12N2320/32

Abstract: Aspects of the disclosure relate to compositions and methods for delivering inhibitory nucleic acids to prokaryotic cells using extracellular vesicles (e.g., exosomes, microvesicles, etc.) derived from mammalian cells. The disclosure provides methods for regulating the expression of one or more genes in a prokaryotic cell. The disclosure further provides methods of treating diseases associated with prokaryotic gene dysregulation.

公开(公告)号：US11800205B2

公开(公告)日：2023-10-24

申请号：US16844597

申请日：2020-04-09

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Sanjeev Jagannatha Koppal ,  Zaid Tasneem ,  Dingkang Wang ,  Huikai Xie ,  Brevin Jeffery Tilmon

IPC: G06T7/80 ,  H04N23/45 ,  G03B39/04 ,  G06T5/00 ,  G02B26/08 ,  H04N23/55 ,  H04N23/66

CPC classification number: H04N23/45 ,  G02B26/0841 ,  G03B39/04 ,  G06T5/003 ,  G06T7/80 ,  H04N23/55 ,  H04N23/66

Abstract: Provided is a camera system to obtain high resolution imagery on multiple regions of interest even when the regions of interest are ate different focal depths and in different viewing directions. Embodiments include a high speed camera that operates by reflecting a beam of interest corresponding to a scene of interest into a high-speed passive sensor from a dynamic optical modulator. Embodiments described herein provide a foveating camera design that distributes resolution onto regions of interest by imaging reflections off a scanning micro-electromechanical system (MEMS) mirror. MEMS mirrors are used herein to modulate viewing direction. Embodiments include a camera capturing reflections off of a tiny, fast moving mirror.

公开(公告)号：US11799673B2

公开(公告)日：2023-10-24

申请号：US16841873

申请日：2020-04-07

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Fatemeh Ganji ,  Shahin Tajik ,  Jean-Pierre Seifert ,  Domenic Forte ,  Mark M. Tehranipoor

IPC: H04L9/00 ,  H04L9/32 ,  H04L9/08 ,  H03K19/173 ,  H03K19/096 ,  H03K19/17748

CPC classification number: H04L9/3278 ,  H03K19/0963 ,  H03K19/1737 ,  H03K19/17748 ,  H04L9/002 ,  H04L9/0866 ,  H04L9/3271

Abstract: Combined physical unclonable function (PUFs); methods, apparatuses, systems, and computer program products for enrolling combined PUFs; and methods, apparatuses, systems, and computer program products for authenticating a device physically associated with a combined PUF are described. In an example embodiment, a combined PUF includes a plurality of PUFs and one or more logic gates. Each PUF includes a plurality of stages and an arbiter configured to generate a single PUF response based on response portions generated by the plurality of stages. The one or more logic gates are configured to combine the single PUF response for each of the plurality of PUFs in accordance with a combination function to provide a combined response.

公开(公告)号：US11799448B2

公开(公告)日：2023-10-24

申请号：US17173919

申请日：2021-02-11

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Roozbeh Tabrizian

IPC: H03H9/17 ,  H03H3/02 ,  H03H9/02 ,  H03H9/13

CPC classification number: H03H9/176 ,  H03H3/02 ,  H03H9/02031 ,  H03H9/13 ,  H03H9/175 ,  H03H2003/025 ,  H03H2009/02196

Abstract: A digitally tunable acoustic wave resonator includes, in part, a first electrode positioned above a substrate, a composite stack positioned above the first electrode, and a second electrode positioned above the composite stack. The composite stack may include one or more alternate layers of a ferroelectric layer and a transition-metal nitride layer. The transition-metal nitride layer can be positioned above the ferroelectric layer, except the ferroelectric layer at the top of the composite stack. The ferroelectric layer comprises an aluminum scandium nitride layer Al1-xScxN, where 0

公开(公告)号：US11797736B2

公开(公告)日：2023-10-24

申请号：US17443815

申请日：2021-07-27

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Swarup Bhunia ,  Abdulrahman Alaql

IPC: G06F30/398 ,  G06F30/327 ,  G06F30/392 ,  G06F30/337

CPC classification number: G06F30/327 ,  G06F30/337 ,  G06F30/392 ,  G06F30/398

Abstract: A method of obfuscating a circuit design includes, in part, receiving a netlist of the circuit design, splitting the circuit design into a multitude of partitions, transforming each partitions so as to obfuscate each partition, and stitching the multitude of transformed partitions to form the obfuscated circuit. The netlist may be a register transfer level netlist. The number and the size of partitions may vary. The partitions may be distributed throughout the entirety of the design. The method may further include generating a randomized circuit associated with at least a subset of the partitions, and merging each partition with the partition's associated randomized circuit. The method may further include quantifying the amount of transformation associated with each partition. The method may further include adding a first key to at least one of the obfuscated partitions, and adding a second key to the partition's associated randomized circuit.

公开(公告)号：US20230330237A1

公开(公告)日：2023-10-19

申请号：US18023696

申请日：2021-08-27

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Weizhou Zhang ,  Guangrong Zheng ,  Daohong Zhou ,  Yufeng Xiao ,  Lei Wang

IPC: A61K47/55 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K47/55 ,  A61P35/00 ,  A61K45/06

Abstract: Modulators of Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) are described as well as their use as therapeutic agents for disease, disorders, or symptoms thereof, including those where modulation of NR4A1 is implicated. Such disease and disorders include cancer.

公开(公告)号：US11788056B2

公开(公告)日：2023-10-17

申请号：US17213619

申请日：2021-03-26

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Roy Curtiss, III ,  Shifeng Wang

IPC: C12N1/36 ,  A61P31/04 ,  A61K39/112 ,  A61K39/08 ,  C12N15/74 ,  A61K39/00

CPC classification number: C12N1/36 ,  A61K39/0275 ,  A61K39/08 ,  A61P31/04 ,  C12N15/74 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/542

Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.