公开(公告)号：US20150313498A1

公开(公告)日：2015-11-05

申请号：US14435398

申请日：2013-10-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： Todd Prentice Coleman ,  Rui Ma ,  Michael Bajema ,  Ricardo Gil Da Costa ,  Raynard Fung

IPC分类号： A61B5/0484 ,  A61B5/04 ,  A61B5/00 ,  A61B5/0478 ,  A61B5/0492

CPC分类号： A61B5/0478 ,  A61B5/04012 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/04842 ,  A61B5/04845 ,  A61B5/04847 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/165 ,  A61B5/167 ,  A61B5/168 ,  A61B5/6803 ,  A61B5/6814

摘要： Methods, systems, and devices are disclosed for acquiring and analyzing physiological signals. In one aspect, a physiological sensor device includes a substrate formed of an electrically insulative material and structured to allow physical contact of the device with the frontal region of the head of a user, a recording electrode configured at a first location on the substrate to acquire an electrophysiological signal of the user, a reference electrode configured at a second location on the substrate to acquire a reference signal to the electrophysiological signal, and a ground electrode configured at a third location at least partially between the first and the second locations on the substrate, in which the first location is posterior to the second and third locations, and in which the device is operable when electrically coupled to an electrical circuit to detect physiological signals of the user.

摘要翻译： 公开了用于获取和分析生理信号的方法，系统和装置。 一方面，一种生理传感器装置包括由电绝缘材料形成并被构造成允许该装置与使用者头部的前部区域的物理接触的记录电极，该记录电极配置在该基板上的第一位置以获得 用户的电生理信号，在基板上的第二位置处配置以获取对电生理信号的参考信号的参考电极，以及配置在第三位置处的至少部分地在衬底上的第一和第二位置之间的接地电极 ，其中所述第一位置位于所述第二和第三位置之后，并且其中所述装置在电耦合到电路以操作以检测所述用户的生理信号时可操作。

公开(公告)号：US20140323901A1

公开(公告)日：2014-10-30

申请号：US14360743

申请日：2012-10-22

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Dong Hwan Kim ,  Sung Kee Park ,  Jong Suk Choi

IPC分类号： A61B5/0484

CPC分类号： A61B5/04842 ,  A61B5/0484 ,  A61B5/04845 ,  A61B5/04847

摘要： The present invention relates to a robot-based autism diagnosis device using an electroencephalogram and to a method therefor. The invention comprises: an electroencephalogram signal detector which is worn on or attached to the head of a child showing signs of autism and detects an electroencephalogram signal generated following an event which is provided; and a robot for diagnosing the degree of autism on receiving the electroencephalogram signal detected by the electroencephalogram signal detector. In the invention, a relatively accurate judgment is made as to whether autism is present, and autism diagnosis is achieved at an early stage such that autistic children can receive treatment for the signs of autism at an early stage.

摘要翻译： 本发明涉及使用脑电图的基于机器人的自闭症诊断装置及其方法。 本发明包括：脑电波信号检测器，其佩戴在或附着到显示自闭症迹象的儿童的头部，并检测在提供的事件之后产生的脑波信号; 以及用于在接收由脑波信号检测器检测到的脑波信号时诊断自闭症程度的机器人。 在本发明中，对自闭症是否存在进行了比较准确的判断，并且早期实现了自闭症诊断，以便自闭症儿童能够早期接受自闭症的治疗。

公开(公告)号：US20100185115A1

公开(公告)日：2010-07-22

申请号：US12710603

申请日：2010-02-23

申请人： Elvir Causevic ,  Christian Christiansen ,  Eldar Causevic

发明人： Elvir Causevic ,  Christian Christiansen ,  Eldar Causevic

IPC分类号： A61B5/0484

CPC分类号： A61B5/0482 ,  A61B5/0484 ,  A61B5/04845 ,  A61B5/04847 ,  A61B5/6815 ,  A61B5/6838

摘要： Apparatus (10) for evoking and recording bio-potentials from a human subject and methods of use are described. The apparatus (10) includes a flexible member (18) with a layer of conductive material (12) disposed thereon for contacting a skin surface on the human subject. The dimensions and shape of the flexible member (18) are adapted for conforming contact between the conductive material (12) and the skin surface. A stimulus delivery element (28) is coupled to the flexible member (18) for delivering a sensory stimulus to the subject to evoke bio-potentials, which are detected and received through the layer of conductive material (12).

摘要翻译： 描述了用于从人类受试者唤起和记录生物潜力的装置（10）和使用方法。 该设备（10）包括柔性构件（18），其上设置有用于接触人体对象皮肤表面的导电材料层（12）。 柔性构件（18）的尺寸和形状适于使导电材料（12）与皮肤表面之间的接触一致。 刺激递送元件（28）耦合到柔性构件（18），用于将感觉刺激传递给受试者，以引起通过导电材料层（12）检测和接收的生物电位。

公开(公告)号：US20090112117A1

公开(公告)日：2009-04-30

申请号：US11977272

申请日：2007-10-24

申请人： Gaurav Rewari

发明人： Gaurav Rewari

IPC分类号： A61B5/0476

CPC分类号： A61B5/0476 ,  A61B5/026 ,  A61B5/04008 ,  A61B5/04842 ,  A61B5/04845 ,  A61B5/04847

摘要： The present invention discloses a method for monitoring the blood flow in the cerebral vasculature of a subject. The method includes measuring the electrophysiological activity of different regions in the brain in the excited or unexcited state. The measured electrophysiological activity of each region is then compared with the baseline of the electrophysiological activity of that region for the corresponding state. External stimuli or the performance of specific tasks by the subject can be used to excite different regions of the brain. Any deviation in the measured electrophysiological activity from the baseline indicates an altered blood flow in that region of the brain. Identification of this particular region of the brain which has altered activity can be carried out based on the external stimuli that resulted in the altered activity. Specific branches of the cerebral vasculature with an altered blood flow may also be determined based on the regions of the brain showing altered electrophysiological activity.

摘要翻译： 本发明公开了一种用于监测受试者的脑血管中的血流的方法。 该方法包括测量兴奋或未激发状态下脑中不同区域的电生理活性。 然后将每个区域的测量的电生理活性与相应状态的该区域的电生理活性的基线进行比较。 外部刺激或受试者的特定任务的表现可用于激发大脑的不同区域。 测量的电生理活动与基线的任何偏差表示该脑区域的血流量改变。 可以基于导致改变的活性的外部刺激来进行具有改变的活性的这一具体区域的鉴定。 具有改变的血流量的脑血管系统的特定分支也可以基于显示改变的电生理活性的脑区域来确定。

公开(公告)号：US20080255949A1

公开(公告)日：2008-10-16

申请号：US12101093

申请日：2008-04-10

申请人： Stephen J. Genco ,  Fernando Miranda ,  Jennifer Mangels ,  David Remer

发明人： Stephen J. Genco ,  Fernando Miranda ,  Jennifer Mangels ,  David Remer

IPC分类号： G06Q30/00

CPC分类号： A61B5/0205 ,  A61B3/112 ,  A61B3/113 ,  A61B5/0484 ,  A61B5/04842 ,  A61B5/04845 ,  A61B5/04847 ,  A61B5/0531 ,  A61B5/0816 ,  A61B5/16 ,  A61B5/162 ,  A61B5/165 ,  G06Q30/02 ,  G06Q30/0241

摘要： Systems and methods of employing experimental tasks, neurological and physiological recording devices, and a sequenced process of data acquisition and analysis to produce measurements of pre-verbal and pre-conscious brain processes. An array of measurement devices are connected non-invasively to an individual (the subject). The subject experiences one or more external stimuli via any combination of senses, including visual, auditory, tactile, olfactory, and/or gustatory. Experimental tasks, data acquisition, analysis, and/or presentation steps are processed to ascertain the subject's pre-verbal and pre-conscious responses to the external stimuli, including attentional triggering, emotional valence and arousal, interest, engagement, and activation of higher cognitive processes such as memory, preference formation, and decision making.

摘要翻译： 使用实验任务，神经和生理记录装置的系统和方法，以及数据采集和分析的顺序过程，以产生语言前和预注意脑部过程的测量。 一组测量装置非侵入性地连接到个体（被摄体）。 该主题通过任何感觉的组合体验一种或多种外部刺激，包括视觉，听觉，触觉，嗅觉和/或味觉。 处理实验任务，数据采集，分析和/或呈现步骤以确定受试者对外部刺激的语言前和预先意识的反应，包括注意触发，情绪价值和唤醒，兴趣，参与和激活较高认知 记忆，偏好形成和决策等过程。

公开(公告)号：US06994671B2

公开(公告)日：2006-02-07

申请号：US10070170

申请日：2001-06-25

申请人： Hiroaki Oka ,  Ryuta Ogawa ,  Tetsuo Yukimasa

发明人： Hiroaki Oka ,  Ryuta Ogawa ,  Tetsuo Yukimasa

IPC分类号： A61B5/08 ,  A61B5/00 ,  A61N1/30 ,  A61M31/00

CPC分类号： G01N33/5088 ,  A01K1/031 ,  A01K29/005 ,  A61B5/0478 ,  A61B5/04847 ,  A61B5/4011 ,  A61B2562/0209 ,  A61B2562/046 ,  G01N2333/46

摘要： A method and apparatus for readily and reliably screening olfactory mucosa stimulating compounds are provided. An olfactory mucosa stimulating compound is sprayed through an atomizing nozzle 33 to an olfactory mucosa of a rat fixed in a test animal fixing device 32. A measuring electrode portion 10 is implanted in an olfactory bulb of the rat for measuring an electrical signal generated in the olfactory bulb. Efficacy of the olfactory mucosa stimulating compound is determined based on a correlation between an electrical signal measured by the measuring electrode portion 10 when the olfactory mucosa stimulating compound is sprayed on the olfactory mucosa of the rat and a physiological response induced in the rat.

摘要翻译： 提供了一种容易可靠地筛选嗅觉粘膜刺激化合物的方法和装置。 将嗅粘膜刺激性化合物通过雾化喷嘴33喷射到固定在测试动物固定装置32中的大鼠的嗅粘膜上。 测量电极部分10被植入大鼠的嗅球中，用于测量在嗅球中产生的电信号。 基于当将嗅觉粘膜刺激化合物喷洒在大鼠的嗅粘膜上时由测量电极部分10测量的电信号与在大鼠中诱导的生理反应之间的相关性来确定嗅觉粘膜刺激化合物的功效。

公开(公告)号：US06298263B1

公开(公告)日：2001-10-02

申请号：US09402354

申请日：2000-02-14

申请人： Edward Michael Sedgwick ,  Mehri Sarfarazi ,  Anne Richardson ,  John Martin Behan ,  Steve Van Toller ,  Joanne Allison Grigor

发明人： Edward Michael Sedgwick ,  Mehri Sarfarazi ,  Anne Richardson ,  John Martin Behan ,  Steve Van Toller ,  Joanne Allison Grigor

IPC分类号： A61B504

CPC分类号： A61B5/04847 ,  A61B5/4011

摘要： A method of odor selection for selecting an odor to match a visual or auditory target stimulus, comprising evaluating a number of odor/target stimulus combinations by testing a subject by presenting the subject with one or more odors under different conditions, at least some conditions being in the presence of one or more target stimuli monitoring brain activity of the subject and evaluating the monitored brain activity in relation to odor/target stimulus combinations presented to the subject and selecting the odor/target stimulus combination or combinations indicated as having the greatest degree of association.

摘要翻译： 一种用于选择气味以匹配视觉或听觉目标刺激的气味选择方法，包括通过在不同条件下呈现受试者一种或多种气味来测试受试者来评估多种气味/目标刺激组合，至少一些条件是 在一个或多个目标刺激物的存在下，监测受试者的脑活动，并评估与给予对象的气味/靶刺激组合相关的监测的大脑活动，并选择指示为最大程度的气味/目标刺激组合或组合 协会。

公开(公告)号：US4940056A

公开(公告)日：1990-07-10

申请号：US271317

申请日：1988-11-15

申请人： Gerard L. Heck ,  John A. DeSimone

发明人： Gerard L. Heck ,  John A. DeSimone

IPC分类号： A61B5/0408 ,  A61B5/0484

CPC分类号： A61B5/04085 ,  A61B5/0484 ,  A61B5/04847 ,  A61B5/4017

摘要： The invention discloses an electrogustograph for detecting the physiological responses of the tongue to various tastants applied thereto through a small vacuum sensor. The small sensor has a peripheral annual vacuum port by which the sensor is attached to the top surface of the tongue. The annular vacuum port surrounds a cavity which has one port for insertion of the tastant which flows across the surface of a portion of the tongue to a second port which serves as an outlet for the tastant. Electrodes are present in the sensor and on the cheek of the person being tested so as to measure the difference in the flow of electricity across the top surface of the tongue when various tastants are applied to the tongue. The electrogustograph is supported by suitable electronics and fluid flow pumps and valves all under the control of a microcontroller to provide a flexible and relatively easy to use electrogustographic system.

摘要翻译： 本发明公开了一种电气绘图仪，用于通过小型真空传感器检测舌头对各种滋味剂的生理反应。 小传感器具有周边的年度真空端口，传感器通过该真空端口连接到舌头的顶部表面。 环形真空端口包围空腔，该空腔具有用于插入促进剂的一个端口，该端口流过舌片的一部分的表面，作为用作促味剂的出口的第二端口。 电极存在于传感器和被测试者的脸颊上，以便当将各种滋味剂施用到舌头时，测量穿过舌头顶表面的电流差异。 电气绘图仪由合适的电子元件和流体流量泵和阀门支持，所有这些都在微控制器的控制下，提供灵活且相对易于使用的电图系统。