公开(公告)号：US09442036B2

公开(公告)日：2016-09-13

申请号：US13001314

申请日：2009-06-26

申请人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

发明人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

IPC分类号： G01L27/00 ,  G01N33/49 ,  G01M3/28 ,  A61M1/36

CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

摘要： A method of monitoring the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The pressure sensor detects first pulses originating from a first pulse generator in the first fluid containing system and second pulses originating from a second pulse generator in the second fluid containing system. A parameter value representing a distribution of signal values within a time window is calculated by analyzing the measurement signal in the time domain and/or by using information on the timing of the second pulses in the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or from matching the signal to a predicted temporal signal profile of the second pulse. The integrity of the fluid connection is determined from the parameter value.

摘要翻译： 基于来自第一流体容纳系统中的压力传感器的至少一个与时间相关的测量信号来监测第一和第二流体容纳系统之间的流体连接的完整性的方法。 压力传感器检测来自第一流体容纳系统中的第一脉冲发生器的第一脉冲和源自第二流体容纳系统中的第二脉冲发生器的第二脉冲。 通过在时域中分析测量信号和/或通过使用关于测量信号中的第二脉冲的定时的信息来计算表示时间窗内的信号值分布的参数值。 可以将参数值计算为信号值的统计色散测量值，或者将信号与第二脉冲的预测时间信号分布匹配。 根据参数值确定流体连接的完整性。

公开(公告)号：US09333321B2

公开(公告)日：2016-05-10

申请号：US13453663

申请日：2012-04-23

申请人： Timothy W. I. Clark

发明人： Timothy W. I. Clark

IPC分类号： A61M25/14 ,  A61M25/00 ,  A61M1/36

CPC分类号： A61M25/003 ,  A61M1/3496 ,  A61M1/3661 ,  A61M25/007 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0037

摘要： The invention provides a catheter for placement within a vessel of a patient. The catheter comprises an elongated catheter body, a septum extending longitudinally through the interior of the catheter body from the dividing the interior of the catheter body into a first lumen and a second lumen. Each lumen has curved or angled internal walls at the distal end of the catheter that terminate at ports located on opposing sides of the catheter body. The invention also provides a method for exchanging fluids in a patient comprising the step of positioning the catheter of the present invention in communication with a fluid-containing vessel of a patient. The method is particularly well-suited for hemodialysis, plasmapheresis, and other therapies which require removal and return of blood from a patient.

公开(公告)号：US09308312B2

公开(公告)日：2016-04-12

申请号：US12673811

申请日：2008-08-20

申请人： Alexander Heide ,  Jürgen Klewinghaus ,  Wolfram Langkau

发明人： Alexander Heide ,  Jürgen Klewinghaus ,  Wolfram Langkau

IPC分类号： A61M37/00 ,  A61M1/36 ,  A61B5/15 ,  A61M5/168

CPC分类号： A61M1/3656 ,  A61B5/1411 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150511 ,  A61B5/150961 ,  A61B5/153 ,  A61B5/155 ,  A61B5/7405 ,  A61M1/3653 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16836 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3375 ,  A61M2205/44 ,  A61M2205/581

摘要： The present invention relates to a device and a method for monitoring a patient access, particularly for monitoring the venous vascular access in extracorporeal blood treatment where blood is withdrawn from the patient via a flexible arterial line which has an arterial needle or cannula, and provided to the patient via a flexible venous line which has a venous needle or cannula. The needle or cannula of the present invention is so designed that, due to the liquid flowing through the needle or cannula, air is drawn in if the needle or cannula is out of the vascular access, whereby sound is generated. A vascular access which is not in proper order is detected with great certainty and reliability by monitoring the surrounding environment for the occurrence of sound, particularly for the occurrence of the solid-borne sound which propagates along the flexible venous line of the extracorporeal blood circuit.

摘要翻译： 本发明涉及一种用于监测患者进入的装置和方法，特别是用于监测体外血液处理中的静脉血管通路，其中通过具有动脉针或套管的柔性动脉线从患者身体抽出血液，并提供给 患者经由具有静脉针或套管的柔性静脉线。 本发明的针或套管被设计成使得由于液体流过针或套管，如果针或套管超出血管通路，则吸入空气，从而产生声音。 通过监测周围环境发生声音，特别是出现沿着体外血液回路的柔性静脉线传播的固体声音，可以很大的确定性和可靠性来检测不正确的血管通路。

公开(公告)号：US09295394B2

公开(公告)日：2016-03-29

申请号：US13888585

申请日：2013-05-07

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Pascal Kopperschmidt ,  Malte Gross ,  Reiner Spickermann

IPC分类号： A61M1/36 ,  A61B5/02

CPC分类号： A61B5/02042 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/18 ,  A61M2205/3331

摘要： A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line is provided. A device for extracorporeal blood treatment comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extracorporeal blood treatment. One aspect of the method and the device is that pressure changes that come from a pressure level exhibiting a large difference from a reference value are more strongly considered than those that come from a pressure level that exhibits only a minor difference from the reference value.

公开(公告)号：US09289544B2

公开(公告)日：2016-03-22

申请号：US13519146

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61M1/30 ,  A61M1/36 ,  A61M5/168

CPC分类号： A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

摘要： A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

摘要翻译： 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

公开(公告)号：US20160074567A1

公开(公告)日：2016-03-17

申请号：US14680846

申请日：2015-04-07

申请人： ASIT ENGINEERING CORP.

发明人： RENATO GIORDANO ,  RODNEY CORDER

IPC分类号： A61M1/16

CPC分类号： A61M1/1605 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1609 ,  A61M1/1621 ,  A61M1/1645 ,  A61M1/1654 ,  A61M1/1658 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/3626 ,  A61M1/3661 ,  A61M2205/125 ,  A61M2205/126 ,  A61M2205/127 ,  A61M2205/15 ,  A61M2205/27 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3327 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3653 ,  A61M2205/50 ,  A61M2205/75

摘要： A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. Preferably, the filter has a vapor membrane for releasing gases including ammonia, but not liquids such as the dialysate. The reused dialysis machine possesses a reservoir for dialysate, an ammonia sensor adjacent to the vapor membrane, a level sensor, a blood leak sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment.

摘要翻译： 提供便携式血液透析系统，其包括一次性药筒和再次使用的透析机。 一次性药筒包括透析液流动路径和通过透析器沿相反方向流动的血液流路。 一次性药筒包括用于从透析液中除去废物的过滤器，以及压力和流体流量传感器，用于测量透析液流路和血液流路中的压力和流体流量。 优选地，过滤器具有用于释放包括氨的气体的蒸气膜，但不是透析液等液体。 重复使用的透析机具有用于透析液的储存器，邻近蒸汽膜的氨传感器，液位传感器，血液泄漏传感器，静脉血管线压力传感器，静脉血液线泡沫检测器，泵电机以及连接到 用于控制和监测血液透析治疗的电机和传感器。

公开(公告)号：US20160051745A1

公开(公告)日：2016-02-25

申请号：US14930526

申请日：2015-11-02

申请人： C. R. Bard, Inc.

发明人： Colin S. Gregersen

IPC分类号： A61M1/36 ,  A61M25/00

CPC分类号： A61M1/3661 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0023 ,  A61M25/0026 ,  A61M25/0029 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0071 ,  A61M25/0074 ,  A61M2025/0031 ,  A61M2025/0037 ,  A61M2025/0078

摘要： A catheter for vascular insertion, including a catheter body defining a first lumen and a second lumen, and including a distal region. The distal region includes an atraumatic nose portion defining a first distal opening in fluid communication with the first lumen, and a second distal opening in fluid communication with the second lumen. The distal region also includes a first lateral opening defined by the catheter body and in fluid communication with the first lumen, and a second lateral opening defined by the catheter body and in fluid communication with the second lumen. One or both of the first and second lateral openings may be defined by an angle cross-cut through an outer perimeter of the catheter body.

摘要翻译： 一种用于血管插入的导管，包括限定第一腔和第二腔的导管主体，并且包括远端区域。 远侧区域包括限定与第一内腔流体连通的第一远端开口的无创伤鼻部，以及与第二内腔流体连通的第二远端开口。 远侧区域还包括由导管主体限定并与第一内腔流体连通的第一侧向开口和由导管主体限定并与第二管腔流体连通的第二侧向开口。 第一和第二侧开口中的一个或两个可以通过穿过导管主体的外周边的角度横切来限定。

公开(公告)号：US20150374952A1

公开(公告)日：2015-12-31

申请号：US14852934

申请日：2015-09-14

申请人： Covidien LP

发明人： Marc Bellisario ,  David Thomashey

IPC分类号： A61M25/00

CPC分类号： A61M25/003 ,  A61M1/3661 ,  A61M25/0069 ,  A61M25/007 ,  A61M25/0071 ,  A61M2025/0031 ,  A61M2025/0073

摘要： A medical catheter assembly includes a catheter tip coupled to a distal end of an elongate catheter member and is symmetric about a plane defined by a septum of the elongate catheter member. The catheter tip defines first and second lumens, and the catheter tip defines first and second openings in the distal portion of the catheter tip. Each opening of the catheter tip is defined by a respective side surface of the catheter tip. Each opening is in fluid communication with a respective one of the first and second lumens of the catheter tip and with a respective one of a pair of lumens defined by the elongate catheter member. The distance between upper and lower surfaces of the catheter tip decreases from a distal end of the proximal portion toward a closed distal end of the catheter tip.

摘要翻译： 医疗导管组件包括联接到细长导管构件的远端的导管末端，并且关于由细长导管构件的隔膜限定的平面对称。 导管末端限定第一和第二腔，并且导管尖端限定导管尖端的远端部分中的第一和第二开口。 导管尖端的每个开口由导管尖端的相应侧表面限定。 每个开口与导管末端的第一和第二腔中的相应一个流体连通，并且由细长的导管构件限定的一对管腔中的相应的一个流体连通。 导管尖端的上表面和下表面之间的距离从近端部分的远端朝向导管尖端的封闭远端减小。

公开(公告)号：US20150306293A1

公开(公告)日：2015-10-29

申请号：US14651730

申请日：2013-12-11

申请人： GAMBRO LUNDIA AB

发明人： Jan Sternby ,  Mattias Holmer ,  Bo Olde ,  Kristian Solem ,  Anders Wallenborg ,  Per Hansson

IPC分类号： A61M1/14

CPC分类号： A61M1/14 ,  A61B5/7217 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/50 ,  A61M2230/04 ,  B01D61/30 ,  B01D61/32

摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (1b). A pulse detection block (54) processes the filtered signal (yf) for detection of subject pulses originating from the subject.

摘要翻译： 监测装置（7）对来自血液处理装置的压力信号进行操作。 透析机具有连接到受试者的血管系统的体外血液回路，用于通过透析器泵血，以及用于通过透析器泵送治疗流体的治疗液供给系统。 监测装置（7）具有用于从体外血液回路中的第一压力传感器（6a）获得第一压力信号（y）的第一输入块（50）和用于获得第二压力 来自处理液供给系统中的第二压力传感器（6b）的信号（w）。 仿真块（56）根据第二压力信号（w）产生模拟第一压力传感器（6a）的并行信号响应的仿真第一压力信号（y）和滤波块（53）， 根据第一压力信号（y）和仿真的第一压力信号（y）产生滤波信号（y），以便抑制与第一压力信号（y）相比的滤波信号（y） 来自治疗液供给系统（1b）的信号干扰。 脉冲检测块（54）处理用于检测从被摄体发出的被摄体脉冲的滤波信号（yf）。

公开(公告)号：US20150290383A1

公开(公告)日：2015-10-15

申请号：US14752912

申请日：2015-06-27

申请人： Rex Medical, LP.

发明人： Stephen A. DeFonzo ,  John D. Leedle

IPC分类号： A61M1/36 ,  A61M25/00

CPC分类号： A61M1/3653 ,  A61M1/30 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/1418 ,  A61M25/0028 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/0043 ,  A61M39/284 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0037 ,  A61M2025/004 ,  Y10T24/44744 ,  Y10T24/44752 ,  Y10T24/44761

摘要： A dialysis catheter including a first portion having a first diameter, an elongated distal portion having a second smaller diameter, and a transition portion The first portion includes first and second independent blood withdrawal lumens extending in the first portion, the first withdrawal lumen terminating in the transition portion in a first terminal opening and the second withdrawal lumen terminating in a second terminal opening, the first and second terminal openings being radially spaced and axially adjacent. A longitudinally extending blood delivery lumen extends in the first portion and terminates in a delivery opening in the distal portion of the catheter, the first and second terminal openings positioned proximally of the delivery opening and each of the first and second terminal openings having a curved wall surrounding a portion of the terminal opening.

摘要翻译： 一种透析导管，其包括具有第一直径的第一部分，具有第二较小直径的细长远端部分和过渡部分。第一部分包括在第一部分中延伸的第一和第二独立血液回收腔， 在第一端子开口中的过渡部分和第二抽出腔终止在第二端子开口中，第一和第二端子开口径向间隔开并且轴向相邻。 纵向延伸的血液输送腔在第一部分中延伸并终止在导管的远端部分中的输送开口中，第一和第二终端开口位于输送开口的近侧，并且每个第一和第二终端开口具有弯曲的壁 围绕终端开口的一部分。