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公开(公告)号：US10478076B2
公开(公告)日：2019-11-19
申请号：US13519532
申请日：2010-12-22
申请人： Bo Olde , Kristian Solem
发明人： Bo Olde , Kristian Solem
IPC分类号： A61B5/0215 , A61B5/00 , A61M1/36
摘要： A device is configured to monitor a cardiovascular property of a subject. The device obtains measurement data from a primary pressure wave sensor arranged to detect pressure waves in an extracorporeal fluid circuit in fluid communication with the cardiovascular system of the subject. The device has a signal processor configured to generate a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject; determine beat classification data for each heart pulse in the monitoring signal; and calculate, based at least partly on the beat classification data, a parameter value indicative of the cardiovascular property. The beat classification data may distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats. The cardiovascular property may be an arterial status of the cardiovascular system, a degree of calcification in the cardiovascular system, a status of a blood vessel access used for connecting the extracorporeal fluid circuit to the cardiovascular system, a heart rate variability, a heart rate, a heart rate turbulence, an ectopic beat count, or an origin of ectopic beats. The device may be attached to or part of a dialysis machine.
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公开(公告)号：US09632018B2
公开(公告)日：2017-04-25
申请号：US13519245
申请日：2010-12-22
申请人： Bo Olde , Kristian Solem
发明人： Bo Olde , Kristian Solem
CPC分类号： G01N19/08 , A61B5/024 , A61B2562/0247 , A61B2562/226 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04 , A61M2230/06
摘要： A device is configured to monitor the integrity of a connection system between first and second fluid containing systems comprising first and second pulse generators. A pressure sensor is arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The device operates a monitoring method, by generating (42) a time-dependent pressure signal based on measurement data obtained from the pressure sensor such that the pressure signal contains a sequence of apparent pulses. The apparent pulses represent a superposition of the second pulses on the first pulses when the connection system (C) is intact. The device processes (44) the pressure signal to calculate a parameter value based on a pulse feature of at least one of the apparent pulses in the pressure signal. The parameter value represents a disturbance caused by the superposition of the second pulses on the first pulses, and may be given as a measure of statistical dispersion, pulse-to-pulse symmetry, or first pulse similarity. The device determines (45) the integrity of the connection system based at least partly on the parameter value. The first fluid containing system may be an extracorporeal blood circuit, and the second fluid containing system may be a human or animal subject.
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公开(公告)号：US09433356B2
公开(公告)日：2016-09-06
申请号：US13380631
申请日：2010-06-24
申请人： Bo Olde , Kristian Solem
发明人： Bo Olde , Kristian Solem
CPC分类号： A61B5/02 , A61B5/021 , A61B5/02125 , A61B5/0816 , A61B5/0823 , A61B5/4094 , A61B5/411 , A61B5/4818 , A61M1/3639 , A61M2205/3331 , A61M2205/50 , A61M2230/06 , A61M2230/40 , A61M2230/63
摘要： A monitoring device receives a measurement signal obtained by a pressure sensor in an extracorporeal fluid system, such as an extracorporeal blood circuit for a dialysis machine which is in contact with a vascular system of a subject via a fluid connection. The monitoring device processes the measurement signal to identify pressure data that represents pulses originating from a first physiological phenomenon in the subject, excluding the heart of the subject. The first physiological phenomenon may be any of reflexes, voluntary muscle contractions, non-voluntary muscle contractions, a breathing system of the subject, an autonomous system of the subject for blood pressure regulation, or an autonomous system of the subject for body temperature regulation. The monitoring device may detect, present, track or predict a disordered condition of the subject using the pressure data, or monitor the integrity of the fluid connection based on the pressure data.
摘要翻译： 监测装置接收由体液流体系统中的压力传感器获得的测量信号，所述体外流体系统例如经由流体连接与受试者的血管系统接触的用于透析机的体外血液回路。 监测装置处理测量信号以识别表示来自对象中的第一生理现象的脉冲的压力数据，不包括对象的心脏。 第一种生理现象可以是任何反射，自愿肌肉收缩，非自愿肌肉收缩，受试者的呼吸系统，血压调节受试者的自主系统或体温调节对象的自主系统。 监视装置可以使用压力数据来检测，呈现，跟踪或预测对象的无序状态，或者基于压力数据监视流体连接的完整性。
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公开(公告)号：US20140298891A1
公开(公告)日：2014-10-09
申请号：US14129087
申请日：2012-05-23
申请人： Mattias Holmer , Bo Olde , Kristian Solem
发明人： Mattias Holmer , Bo Olde , Kristian Solem
CPC分类号： A61M1/367 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/3331 , A61M2205/3351 , G01N19/00
摘要： A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.
摘要翻译： 一种装置通过体外血液处理装置监测来自人体受试者的血管通路的血液通路并返回到血管通路。 血液路径中的抽吸装置可操作以将血液通过血液通道从血液提取装置泵送到血液返回装置。 监测装置从布置在血液路径中的泵送装置上游的压力传感器获取压力数据，并处理用于检测泵送装置下游的血液路径破裂的压力数据，例如， 由VND引起的（静脉针脱落）。 通过评估压力传感器处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备中的一个或多个脉冲发生器，并且在传播路径上沿着下游的方向传播 泵送装置通过血液回流装置，血管通路和取血装置到压力传感器。
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公开(公告)号：US08831717B2
公开(公告)日：2014-09-09
申请号：US12441921
申请日：2007-09-06
申请人： Kristian Solem , Bo Olde
发明人： Kristian Solem , Bo Olde
CPC分类号： A61M1/14 , A61B5/021 , A61B5/0535 , A61B5/0537 , A61M1/16 , A61M1/34 , A61M1/341 , A61M2205/50 , A61M2230/65
摘要： The invention relates to estimation of a patient's propensity to suffer from symptomatic hypotension during extracorporeal blood treatment. An electromagnetic test signal, which is applied over a thoracic region of the patient via at least one transmitter electrode. A result signal produced in response to the test signal is received via at least one receiver electrode on the patient. A test parameter is derived based on the result signal. The test parameter expresses a fluid status of the thoracic region of the patient, and it is determined whether the test parameter fulfills an alarm criterion. If the test parameter fulfills an alarm criteria, an alarm signal is generated. This signal indicates that the patient is hypotension prone, and that appropriate measures should be taken.
摘要翻译： 本发明涉及在体外血液治疗期间估计患者患有症状性低血压的倾向。 电磁测试信号，其通过至少一个发射器电极施加在患者的胸部区域上。 响应于测试信号产生的结果信号经由患者上的至少一个接收器电极被接收。 基于结果信号导出测试参数。 测试参数表示患者胸部区域的流体状态，确定测试参数是否满足报警标准。 如果测试参数符合报警标准，则会产生报警信号。 该信号表示患者是低血压倾向，应采取适当的措施。
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公开(公告)号：US20140231319A1
公开(公告)日：2014-08-21
申请号：US14234527
申请日：2012-06-20
申请人： Bo Olde , Kristian Solem , Mattias Holmer , Jan Sternby
发明人： Bo Olde , Kristian Solem , Mattias Holmer , Jan Sternby
CPC分类号： A61M1/3607 , A61B5/02108 , A61B5/6866 , A61B5/7217 , A61M1/34 , A61M1/3403 , A61M1/3621 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M2205/3331 , A61M2205/3368 , A61M2205/50 , B01D61/30 , B01D61/32 , G01L19/00
摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.
摘要翻译： 装置去除压力传感器的压力信号中的第一脉冲，该压力传感器布置在流体容纳系统中，以检测源自第一脉冲发生器的第一脉冲和来自第二脉冲发生器的第二脉冲。 第一脉冲发生器以脉冲周期的顺序操作，每个脉冲周期产生至少一个第一脉冲。 设备重复获取当前数据样本，计算相应的参考值，并从当前数据样本中减去参考值。 参考值根据相同压力信号中其他数据采样的函数计算。 流体容纳系统可以包括体外血流回路，例如， 作为透析机的一部分，以及人类患者的心血管系统。
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公开(公告)号：US08718957B2
公开(公告)日：2014-05-06
申请号：US12988146
申请日：2009-04-16
申请人： Martin Furmanski , Anders Roslund , Bo Olde , Kristian Solem
发明人： Martin Furmanski , Anders Roslund , Bo Olde , Kristian Solem
IPC分类号： G01F17/00
CPC分类号： G01M3/2815 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M5/16859 , A61M2205/15 , A61M2205/18 , A61M2230/06
摘要： A device is provided for monitoring the integrity of a flow circuit in fluid communication with a receptacle. The flow circuit includes a pumping device for transferring fluid through the flow circuit. The device operates according to a monitoring method in which a pressure signal is received from a pressure sensor, the pressure signal being indicative of fluid pressure in the receptacle or the flow circuit. The pressure signal is then processed for detection of a beating signal. The beating signal manifests itself as an amplitude modulation of the pressure signal and is formed by interference between pressure waves generated by a pulse generator associated with the receptacle and pressure waves generated by the pumping device. The integrity of the flow circuit is determined based at least partly on the presence or absence of the beating signal. The device and the flow circuit may be part of an apparatus for extracorporeal blood treatment, and the method may be implemented as a computer program product.
摘要翻译： 提供了一种用于监测与容器流体连通的流动回路的完整性的装置。 流动回路包括用于通过流动回路传送流体的泵送装置。 该装置根据其中从压力传感器接收压力信号的监测方法进行操作，压力信号表示容器或流路中的流体压力。 然后处理压力信号以检测跳动信号。 跳动信号表现为压力信号的幅度调制，并且由与由插座相关联的脉冲发生器产生的压力波和由泵送装置产生的压力波之间的干扰形成。 至少部分地基于跳动信号的存在或不存在确定流动电路的完整性。 装置和流路可以是用于体外血液处理的装置的一部分，并且该方法可以被实现为计算机程序产品。
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公开(公告)号：US08715216B2
公开(公告)日：2014-05-06
申请号：US13000856
申请日：2009-06-26
申请人： Bo Olde , Kristian Solem
发明人： Bo Olde , Kristian Solem
IPC分类号： A61M37/00
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A monitoring device is arranged to receive a time-dependent measurement signal from a pressure sensor in a fluid containing system, which is associated with a first pulse generator and a second pulse generator. The pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator. The monitoring device is configured to process the measurement signal to remove the first pulse. In this process, the monitoring device receives the measurement signal, obtains a first pulse profile which is a predicted temporal signal profile of the first pulse, and filters the measurement signal in the time-domain, using the first pulse profile, to essentially eliminate the first pulse while retaining the second pulse. The fluid containing system may include an extracorporeal blood flow circuit and a blood circuit of a human patient.
摘要翻译： 监视装置被布置成从与第一脉冲发生器和第二脉冲发生器相关联的流体容纳系统中的压力传感器接收与时间相关的测量信号。 压力传感器布置在流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。 监视装置被配置为处理测量信号以去除第一脉冲。 在该过程中，监视装置接收测量信号，获得作为第一脉冲的预测时间信号分布的第一脉冲分布，并使用第一脉冲分布对时域中的测量信号进行滤波，基本上消除 第一个脉冲同时保留第二个脉冲。 流体容纳系统可以包括体外血液回路和人类患者的血液回路。
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公开(公告)号：US20130204542A1
公开(公告)日：2013-08-08
申请号：US13519245
申请日：2010-12-22
申请人： Bo Olde , Kristian Solem
发明人： Bo Olde , Kristian Solem
IPC分类号： G01N19/08
CPC分类号： G01N19/08 , A61B5/024 , A61B2562/0247 , A61B2562/226 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04 , A61M2230/06
摘要： A device is configured to monitor the integrity of a connection system between first and second fluid containing systems comprising first and second pulse generators. A pressure sensor is arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The device operates a monitoring method, by generating (42) a time-dependent pressure signal based on measurement data obtained from the pressure sensor such that the pressure signal contains a sequence of apparent pulses. The apparent pulses represent a superposition of the second pulses on the first pulses when the connection system (C) is intact. The device processes (44) the pressure signal to calculate a parameter value based on a pulse feature of at least one of the apparent pulses in the pressure signal. The parameter value represents a disturbance caused by the superposition of the second pulses on the first pulses, and may be given as a measure of statistical dispersion, pulse-to-pulse symmetry, or first pulse similarity. The device determines (45) the integrity of the connection system based at least partly on the parameter value. The first fluid containing system may be an extracorporeal blood circuit, and the second fluid containing system may be a human or animal subject.
摘要翻译： 设备被配置为监视包括第一和第二脉冲发生器的第一和第二流体容纳系统之间的连接系统的完整性。 压力传感器布置在第一流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。 该装置通过基于从压力传感器获得的测量数据产生（42）依赖于时间的压力信号来操作监视方法，使得压力信号包含表观脉冲序列。 当连接系统（C）完好时，表观脉冲表示第一脉冲上的第二脉冲的叠加。 装置处理（44）压力信号，以基于压力信号中的表观脉冲中的至少一个的脉冲特征来计算参数值。 参数值表示由第二脉冲叠加在第一脉冲上引起的干扰，并且可以作为统计色散，脉冲对脉冲对称或第一脉冲相似度的量度给出。 该设备至少部分地基于参数值确定（45）连接系统的完整性。 第一流体容纳系统可以是体外血液回路，并且第二流体容纳系统可以是人或动物受试者。
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公开(公告)号：US20110112595A1
公开(公告)日：2011-05-12
申请号：US13000856
申请日：2009-06-26
申请人： Kristian Solem , Bo Olde
发明人： Kristian Solem , Bo Olde
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A monitoring device is arranged to receive a time-dependent measurement signal from a pressure sensor in a fluid containing system, which is associated with a first pulse generator and a second pulse generator. The pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator. The monitoring device is configured to process the measurement signal to remove the first pulse. In this process, the monitoring device receives the measurement signal, obtains a first pulse profile which is a predicted temporal signal profile of the first pulse, and filters the measurement signal in the time-domain, using the first pulse profile, to essentially eliminate the first pulse while retaining the second pulse. The fluid containing system may include an extracorporeal blood flow circuit and a blood circuit of a human patient.
摘要翻译： 监视装置被布置成从与第一脉冲发生器和第二脉冲发生器相关联的流体容纳系统中的压力传感器接收与时间相关的测量信号。 压力传感器布置在流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。 监视装置被配置为处理测量信号以去除第一脉冲。 在该过程中，监视装置接收测量信号，获得作为第一脉冲的预测时间信号分布的第一脉冲分布，并且使用第一脉冲分布对时域中的测量信号进行滤波，以基本上消除 第一个脉冲同时保留第二个脉冲。 流体容纳系统可以包括体外血液回路和人类患者的血液回路。
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