公开(公告)号：US09427513B2

公开(公告)日：2016-08-30

申请号：US14129087

申请日：2012-05-23

Applicant: Mattias Holmer ,  Bo Olde ,  Kristian Solem

Inventor： Mattias Holmer ,  Bo Olde ,  Kristian Solem

IPC: A61M37/00 ,  A61M1/36 ,  G01N19/00

CPC classification number: A61M1/367 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2205/3351 ,  G01N19/00

Abstract: A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.

Abstract translation: 一种装置通过体外血液处理装置监测来自人体受试者的血管通路的血液通路并返回到血管通路。 血液路径中的抽吸装置可操作以将血液通过血液通道从血液提取装置泵送到血液返回装置。 监测装置从布置在血液路径中的泵送装置上游的压力传感器获取压力数据，并处理用于检测泵送装置下游的血液路径破裂的压力数据，例如， 由VND引起的（静脉针脱落）。 通过评估压力传感器处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备中的一个或多个脉冲发生器，并且在传播路径上沿着下游的方向传播 泵送装置通过血液回流装置，血管通路和取血装置到压力传感器。

公开(公告)号：US20130150766A1

公开(公告)日：2013-06-13

申请号：US13519146

申请日：2010-12-22

Applicant: Bo Olde ,  Kristian Solem

Inventor： Bo Olde ,  Kristian Solem

IPC: A61M1/30

CPC classification number: A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

Abstract: A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

Abstract translation: 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

公开(公告)号：US20130023776A1

公开(公告)日：2013-01-24

申请号：US13519532

申请日：2010-12-22

Applicant: Bo Olde ,  Kristian Solem

Inventor： Bo Olde ,  Kristian Solem

IPC: A61B5/024 ,  A61B5/0215

Abstract: A device is configured to monitor a cardiovascular property of a subject. The device obtains measurement data from a primary pressure wave sensor arranged to detect pressure waves in an extracorporeal fluid circuit in fluid communication with the cardiovascular system of the subject. The device has a signal processor configured to generate a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject; determine beat classification data for each heart pulse in the monitoring signal; and calculate, based at least partly on the beat classification data, a parameter value indicative of the cardiovascular property. The beat classification data may distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats. The cardiovascular property may be an arterial status of the cardiovascular system, a degree of calcification in the cardiovascular system, a status of a blood vessel access used for connecting the extracorporeal fluid circuit to the cardiovascular system, a heart rate variability, a heart rate, a heart rate turbulence, an ectopic beat count, or an origin of ectopic beats. The device may be attached to or part of a dialysis machine.

Abstract translation: 设备被配置为监测受试者的心血管性质。 该装置从一次压力波传感器获得测量数据，其被布置成检测体液流体回路中与受试者的心血管系统流体连通的压力波。 该装置具有信号处理器，其被配置为基于测量数据产生与时间相关的监视信号，使得监视信号包括心脏脉冲序列，其中每个心脏脉搏表示源自受试者的心跳的压力波; 确定监测信号中每个心脏脉搏的搏动分类数据; 并且至少部分地基于节拍分类数据计算指示心血管特性的参数值。 节拍分类数据可以区分源自正常心跳的心脏脉搏和源自异位心跳的心脏脉冲。 心血管功能可以是心血管系统的动脉状态，心血管系统中的钙化程度，用于将体外流体回路连接到心血管系统的血管通路的状态，心率变异性，心率， 心率湍流，异位搏动计数或异位搏动的来源。 该装置可以附接到透析机或透析机的一部分。

公开(公告)号：US20130006130A1

公开(公告)日：2013-01-03

申请号：US13519483

申请日：2010-12-22

Applicant: Bo Olde ,  Kristian Solem

Inventor： Bo Olde ,  Kristian Solem

IPC: A61B5/02

CPC classification number: A61B5/026 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3658 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2230/04 ,  A61M2230/42

Abstract: A device in an apparatus for extracorporeal blood treatment is configured to monitor a fluid flow rate (Q) of a cardiovascular system of a subject. The apparatus comprises an extracorporeal blood circuit and a connection (C) for connecting the extracorporeal blood circuit to the cardiovascular system. The device comprises an input for obtaining a time-dependent measurement signal (d(n)) from a pressure sensor in the extracorporeal blood circuit. The pressure sensor is arranged to detect a subject pulse originating from a subject pulse generator in the cardiovascular system of the subject, wherein the system further comprises a signal processor connected to the input. The signal processor is configured to process the measurement signal to obtain a pulse profile (e(n)) which is a temporal signal profile of the subject pulse, and to calculate a fluid flow rate (Q) based at least partly on the temporal signal profile.

Abstract translation: 用于体外血液处理的装置中的装置被配置为监测受试者的心血管系统的流体流速（Q）。 该装置包括体外血液回路和用于将体外血液回路连接到心血管系统的连接（C）。 该装置包括用于从体外血液回路中的压力传感器获得与时间有关的测量信号（d（n））的输入。 压力传感器被布置成检测来自主体的心血管系统中的受检者脉冲发生器的被检体脉冲，其中该系统还包括连接到该输入端的信号处理器。 信号处理器被配置为处理测量信号以获得作为对象脉冲的时间信号轮廓的脉冲轮廓（e（n）），并且至少部分地基于时间信号来计算流体流速（Q） 个人资料

公开(公告)号：US20130006128A1

公开(公告)日：2013-01-03

申请号：US13519559

申请日：2010-12-22

Applicant: Bo Olde ,  Kristian Solem

Inventor： Bo Olde ,  Kristian Solem

IPC: A61B5/0215 ,  A61B5/024

Abstract: A monitoring device is included in a medical system to implement a method for prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment such as dialysis. To this aim, a pulse shape parameter (pPS) with respect to a pulse generator of the subject is registered by means of a pressure sensor arranged in an extracorporeal blood flow circuit coupled to a cardiovascular system of the subject (P). The pressure sensor is configured to detect pressure variations in blood vessels of the subject (P). It is investigated, during measurement period, whether or not one or more of the pulse shape parameters fulfil a decision criterion. An output signal (a) is generated if the decision criterion is found to be fulfilled, to indicate a predicted rapid symptomatic blood pressure decrease in the subject (P). The decision criterion may operate on pulse magnitude measures calculated for the received pulse shape parameters (pPS), or statistical dispersion measures calculated based on the thus-calculated pulse magnitude measures.

Abstract translation: 监测装置包括在医疗系统中，以实现用于预测受试者血压的快速症状性下降的方法，例如， 在透析等医疗过程中。 为此，通过布置在耦合到被检体（P）的心血管系统的体外血流回路中的压力传感器来记录相对于被检体的脉冲发生器的脉搏形状参数（pPS）。 压力传感器被配置为检测被检体（P）的血管中的压力变化。 在测量期间，对脉冲形状参数中的一个或多个是否满足判定标准进行了研究。 如果发现判定标准被满足，则产生输出信号（a），以指示被检体（P）中预测的快速有症状的血压下降。 判定标准可以对针对接收的脉冲形状参数（pPS）计算的脉冲幅度测量值进行操作，或者基于由此计算的脉冲幅度测量值计算的统计色散测量值。

公开(公告)号：US08311619B2

公开(公告)日：2012-11-13

申请号：US12066478

申请日：2006-08-10

Applicant: Leif Sörnmo ,  Kristian Solem

Inventor： Leif Sörnmo ,  Kristian Solem

IPC: A61B5/04 ,  A61B5/02

CPC classification number: A61B5/746 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7264 ,  A61M1/30

Abstract: A cardiac-activity based prediction of a rapid drop in a patient's blood pressure during extracorporeal blood treatment is disclosed. A proposed alarm apparatus includes a primary beat morphology analysis unit bank of secondary analysis units and an alarm generating unit. The primary beat morphology analysis unit discriminates heart beats in a received basic electrocardiogram signal, classifies each beat into one out of at least two different beat categories, and associates each segment of the signal with relevant event-type data. The event-type data and the basic electrocardiogram signal together form an enhanced electrocardiogram signal, based upon which the primary beat morphology analysis unit determines whether one or more secondary signal analyses should be performed. Depending on the enhanced electrocardiogram signal's properties, the bank of secondary analysis units performs none, one or more of up to at least two different types of secondary analyses, and for each analysis performed produces a respective test signal. The alarm generating unit receives the test signals, and triggers an alarm signal indicative of an estimated rapid blood pressure decrease, if at least one alarm criterion is fulfilled.

Abstract translation: 公开了一种基于心脏活动的预测体外血液治疗期间患者血压迅速下降的预测。 所提出的报警装置包括二次分析单元的主拍形态分析单元组和报警发生单元。 主要搏动形态分析单元鉴别接收到的基本心电图信号中的心跳，将每个节拍分为至少两个不同节拍类别中的一个，并且将每个信号段与相关的事件类型数据相关联。 事件类型数据和基本心电图信号一起形成增强的心电图信号，基于该心电图信号，初步搏动形态分析单元确定是否应执行一个或多个次要信号分析。 根据增强的心电图信号的性质，二次分析单元组不执行至多两种不同类型的辅助分析中的一个或多个，并且对于执行的每个分析，都产生相应的测试信号。 如果满足至少一个报警标准，则报警发生单元接收测试信号，并触发指示估计的快速血压下降的报警信号。

公开(公告)号：US08287725B2

公开(公告)日：2012-10-16

申请号：US12308052

申请日：2007-06-04

Applicant: Leif Sörnmo ,  Kristian Solem ,  Bo Olde

Inventor： Leif Sörnmo ,  Kristian Solem ,  Bo Olde

IPC: B01D61/12 ,  A61B5/024

CPC classification number: A61B5/14551 ,  A61B5/021 ,  A61B5/02116 ,  A61M1/3639 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2230/30

Abstract: The invention relates to prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfills a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.

Abstract translation: 本发明涉及预测受试者血压中快速有症状的下降，例如， 在治疗期间或在操作飞行器时。 为此目的，通过适于检测血管中的光反应变化的脉搏血氧仪（110）来记录相对于被检体（P）的外周身体部分（105）的脉搏形状参数（Pps）。 基于在一次接收的脉冲形状参数（Pps）来计算初始脉冲幅度测量。 在第一次之后的测量周期期间，基于接收的脉冲形状参数（Pps）的数量来计算相应的脉冲幅度测量。 对于测量周期中的每个脉冲幅度测量，进一步研究测量是否满足相对于初始脉冲幅度测量的判定标准。 如果发现满足判定标准，则产生报警触发信号（α）。

公开(公告)号：US09442036B2

公开(公告)日：2016-09-13

申请号：US13001314

申请日：2009-06-26

Applicant: Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

Inventor： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

IPC: G01L27/00 ,  G01N33/49 ,  G01M3/28 ,  A61M1/36

CPC classification number: G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

Abstract: A method of monitoring the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The pressure sensor detects first pulses originating from a first pulse generator in the first fluid containing system and second pulses originating from a second pulse generator in the second fluid containing system. A parameter value representing a distribution of signal values within a time window is calculated by analyzing the measurement signal in the time domain and/or by using information on the timing of the second pulses in the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or from matching the signal to a predicted temporal signal profile of the second pulse. The integrity of the fluid connection is determined from the parameter value.

Abstract translation: 基于来自第一流体容纳系统中的压力传感器的至少一个与时间相关的测量信号来监测第一和第二流体容纳系统之间的流体连接的完整性的方法。 压力传感器检测来自第一流体容纳系统中的第一脉冲发生器的第一脉冲和源自第二流体容纳系统中的第二脉冲发生器的第二脉冲。 通过在时域中分析测量信号和/或通过使用关于测量信号中的第二脉冲的定时的信息来计算表示时间窗内的信号值分布的参数值。 可以将参数值计算为信号值的统计色散测量值，或者将信号与第二脉冲的预测时间信号分布匹配。 根据参数值确定流体连接的完整性。

公开(公告)号：US09289544B2

公开(公告)日：2016-03-22

申请号：US13519146

申请日：2010-12-22

Applicant: Bo Olde ,  Kristian Solem

Inventor： Bo Olde ,  Kristian Solem

IPC: A61M1/30 ,  A61M1/36 ,  A61M5/168

CPC classification number: A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

Abstract: A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

Abstract translation: 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

公开(公告)号：US20130274570A9

公开(公告)日：2013-10-17

申请号：US13519067

申请日：2010-12-22

Applicant: Bo Olde ,  Kristian Solem

Inventor： Bo Olde ,  Kristian Solem

IPC: A61B5/00 ,  A61M1/30 ,  A61B5/0205

CPC classification number: A61B5/4836 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/02416 ,  A61B5/053 ,  A61M1/30 ,  A61M1/36 ,  A61M2230/30

Abstract: A monitoring arrangement 100 is configured to predict a rapid syruptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (pps) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (pps), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.

Abstract translation: 监测装置100被配置为预测受试者的血压中的快速糖尿病下降。 在医疗或运营飞机时。 为此目的，相对于被检体（P）的周边主体部分（105）的脉冲形状参数（pps）通过适于检测血管中的光反应变化的脉搏血氧仪（110）重复记录。 基于接收的脉冲形状参数（pps）中的每一个来计算相应的脉冲幅度测量，并且基于由此计算的脉冲幅度测量值来计算统计色散测量。 调查统计色散测量是否满足参考测量的决策标准。 如果发现满足判定标准，则产生输出信号（α）。